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ERO1A endoplasmic reticulum oxidoreductase 1 alpha [ Homo sapiens (human) ]

Gene ID: 30001, updated on 4-Jan-2025

Summary

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Official Symbol
ERO1Aprovided by HGNC
Official Full Name
endoplasmic reticulum oxidoreductase 1 alphaprovided by HGNC
Primary source
HGNC:HGNC:13280
See related
Ensembl:ENSG00000197930 MIM:615435; AllianceGenome:HGNC:13280
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ERO1L; ERO1-L; ERO1LA; Ero1alpha; ERO1-alpha; ERO1-L-alpha
Summary
Enables oxidoreductase activity. Involved in cell redox homeostasis and chaperone cofactor-dependent protein refolding. Located in Golgi lumen; endoplasmic reticulum; and extracellular space. [provided by Alliance of Genome Resources, Jan 2025]
Expression
Broad expression in esophagus (RPKM 69.5), placenta (RPKM 19.1) and 21 other tissues See more
Orthologs
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Genomic context

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See ERO1A in Genome Data Viewer
Location:
14q22.1
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (52639915..52695558, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (46847757..46903365, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (53106633..53162276, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene thioredoxin domain containing 16 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5744 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5745 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:53034445-53035160 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:53035161-53035876 Neighboring gene G protein-coupled receptor 137C Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:53062685-53063186 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr14:53130319-53130927 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:53161801-53162302 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8392 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8394 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8393 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8395 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5747 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5748 Neighboring gene Sharpr-MPRA regulatory region 400 Neighboring gene proteasome 26S subunit, ATPase 6 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:53218646-53218797 Neighboring gene serine/threonine/tyrosine interacting protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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Related articles in PubMed

  1. ERO1L promotes NSCLC development by modulating cell cycle-related molecules. Shi X, et al. Cell Biol Int, 2020 Dec. PMID 32841447, Free PMC Article
  2. Targeting the functional interplay between endoplasmic reticulum oxidoreductin-1α and protein disulfide isomerase suppresses the progression of cervical cancer. Zhang Y, et al. EBioMedicine, 2019 Mar. PMID 30826359, Free PMC Article
  3. A novel disulphide switch mechanism in Ero1alpha balances ER oxidation in human cells. Appenzeller-Herzog C, et al. EMBO J, 2008 Nov 19. PMID 18833192, Free PMC Article
  4. Low reduction potential of Ero1alpha regulatory disulphides ensures tight control of substrate oxidation. Baker KM, et al. EMBO J, 2008 Nov 19. PMID 18971943, Free PMC Article
  5. Human endoplasmic reticulum oxidoreductin 1-α is a novel predictor for poor prognosis of breast cancer. Kutomi G, et al. Cancer Sci, 2013 Aug. PMID 23578220, Free PMC Article

See all (153) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SEPN1-related myopathy depends on the oxidoreductase ERO1A and is druggable with the chemical chaperone TUDCA.
    Title: SEPN1-related myopathy depends on the oxidoreductase ERO1A and is druggable with the chemical chaperone TUDCA.
  2. Biological mechanisms and clinical significance of endoplasmic reticulum oxidoreductase 1 alpha (ERO1alpha) in human cancer.
    Title: Biological mechanisms and clinical significance of endoplasmic reticulum oxidoreductase 1 alpha (ERO1α) in human cancer.
  3. ERO1alpha promotes the proliferation and inhibits apoptosis of colorectal cancer cells by regulating the PI3K/AKT pathway.
    Title: ERO1α promotes the proliferation and inhibits apoptosis of colorectal cancer cells by regulating the PI3K/AKT pathway.
  4. Ablation of ERO1A induces lethal endoplasmic reticulum stress responses and immunogenic cell death to activate anti-tumor immunity.
    Title: Ablation of ERO1A induces lethal endoplasmic reticulum stress responses and immunogenic cell death to activate anti-tumor immunity.
  5. ERO1alpha primes the ryanodine receptor to respond to arsenite with concentration dependent Ca[2+] release sequentially triggering two different mechanisms of ROS formation.
    Title: ERO1α primes the ryanodine receptor to respond to arsenite with concentration dependent Ca(2+) release sequentially triggering two different mechanisms of ROS formation.
  6. Endoplasmic reticulum oxidoreductin 1-alpha deficiency and activation of protein translation synergistically impair breast tumour resilience.
    Title: Endoplasmic reticulum oxidoreductin 1-alpha deficiency and activation of protein translation synergistically impair breast tumour resilience.
  7. ERO1 alpha deficiency impairs angiogenesis by increasing N-glycosylation of a proangiogenic VEGFA.
    Title: ERO1 alpha deficiency impairs angiogenesis by increasing N-glycosylation of a proangiogenic VEGFA.
  8. ERO1L promotes the proliferation and metastasis of lung adenocarcinoma via the Wnt2/beta-catenin signaling pathway.
    Title: ERO1L promotes the proliferation and metastasis of lung adenocarcinoma via the Wnt2/β-catenin signaling pathway.
  9. Crosstalk between ERO1alpha and ryanodine receptor in arsenite-dependent mitochondrial ROS formation.
    Title: Crosstalk between ERO1α and ryanodine receptor in arsenite-dependent mitochondrial ROS formation.
  10. ERO1-PDI Redox Signaling in Health and Disease.
    Title: ERO1-PDI Redox Signaling in Health and Disease.
Submit: New GeneRIF Correction See all GeneRIFs (66)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 interacts with GPX7; predicted interaction to be within the endoplasmic reticulum and function as a reductase PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables FAD binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-disulfide reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables thiol oxidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in L-ascorbic acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in brown fat cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in cell redox homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to hypoxia IEA
Inferred from Electronic Annotation
more info
  
involved_in chaperone cofactor-dependent protein refolding IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in collagen fibril organization IEA
Inferred from Electronic Annotation
more info
  
involved_in endoplasmic reticulum unfolded protein response IEA
Inferred from Electronic Annotation
more info
  
involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein folding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein folding in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein maturation by protein folding IEA
Inferred from Electronic Annotation
more info
  
involved_in protein modification process TAS
Traceable Author Statement
more info
 PubMed 
involved_in release of sequestered calcium ion into cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in response to endoplasmic reticulum stress ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in response to oxidative stress IEA
Inferred from Electronic Annotation
more info
  
involved_in response to temperature stimulus TAS
Traceable Author Statement
more info
 PubMed 
involved_in skeletal muscle tissue development IEA
Inferred from Electronic Annotation
more info
  
involved_in transforming growth factor beta receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi lumen IDA
Inferred from Direct Assay
more info
 PubMed 
located_in dendrite IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in intracellular membrane-bounded organelle TAS
Traceable Author Statement
more info
 PubMed 
located_in membrane HDA PubMed 

General protein information

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Preferred Names
ERO1-like protein alpha
Names
endoplasmic oxidoreductin-1-like protein
endoplasmic reticulum oxidoreductase alpha
oxidoreductin-1-L-alpha
NP_001369393.1
NP_001369394.1
NP_001369395.1
NP_001369396.1
NP_001369397.1
NP_001369398.1
NP_001369399.1
NP_001369400.1
NP_001369401.1
NP_001369402.1
NP_001369403.1
NP_001369404.1
NP_001369405.1
NP_055399.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001382464.1 → NP_001369393.1  ERO1-like protein alpha isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AL133453
    Conserved Domains (1) summary
    pfam04137
    Location:60 → 468
    ERO1; Endoplasmic Reticulum Oxidoreductin 1 (ERO1)

  2. NM_001382465.1 → NP_001369394.1  ERO1-like protein alpha isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AL133453
    Conserved Domains (1) summary
    pfam04137
    Location:60 → 451
    ERO1; Endoplasmic Reticulum Oxidoreductin 1 (ERO1)

  3. NM_001382466.1 → NP_001369395.1  ERO1-like protein alpha isoform 4 precursor

    Status: VALIDATED

    Source sequence(s)
    AL133453
    Conserved Domains (1) summary
    pfam04137
    Location:60 → 451
    ERO1; Endoplasmic Reticulum Oxidoreductin 1 (ERO1)

  4. NM_001382467.1 → NP_001369396.1  ERO1-like protein alpha isoform 5 precursor

    Status: VALIDATED

    Source sequence(s)
    AL133453
    Conserved Domains (1) summary
    pfam04137
    Location:60 → 446
    ERO1; Endoplasmic Reticulum Oxidoreductin 1 (ERO1)

  5. NM_001382468.1 → NP_001369397.1  ERO1-like protein alpha isoform 6 precursor

    Status: VALIDATED

    Source sequence(s)
    AL133453
    Conserved Domains (1) summary
    pfam04137
    Location:60 → 442
    ERO1; Endoplasmic Reticulum Oxidoreductin 1 (ERO1)

  6. NM_001382469.1 → NP_001369398.1  ERO1-like protein alpha isoform 7 precursor

    Status: VALIDATED

    Source sequence(s)
    AL133453
    Conserved Domains (1) summary
    pfam04137
    Location:60 → 438
    ERO1; Endoplasmic Reticulum Oxidoreductin 1 (ERO1)

  7. NM_001382470.1 → NP_001369399.1  ERO1-like protein alpha isoform 8 precursor

    Status: VALIDATED

    Source sequence(s)
    AL133453
    Conserved Domains (1) summary
    pfam04137
    Location:60 → 430
    ERO1; Endoplasmic Reticulum Oxidoreductin 1 (ERO1)

  8. NM_001382471.1 → NP_001369400.1  ERO1-like protein alpha isoform 9 precursor

    Status: VALIDATED

    Source sequence(s)
    AL133453
    Conserved Domains (1) summary
    pfam04137
    Location:50 → 426
    ERO1; Endoplasmic Reticulum Oxidoreductin 1 (ERO1)

  9. NM_001382472.1 → NP_001369401.1  ERO1-like protein alpha isoform 10 precursor

    Status: VALIDATED

    Source sequence(s)
    AL133453
    Conserved Domains (1) summary
    pfam04137
    Location:42 → 418
    ERO1; Endoplasmic Reticulum Oxidoreductin 1 (ERO1)

  10. NM_001382473.1 → NP_001369402.1  ERO1-like protein alpha isoform 11 precursor

    Status: VALIDATED

    Source sequence(s)
    AL133453
    Conserved Domains (1) summary
    pfam04137
    Location:60 → 415
    ERO1; Endoplasmic Reticulum Oxidoreductin 1 (ERO1)

  11. NM_001382474.1 → NP_001369403.1  ERO1-like protein alpha isoform 12 precursor

    Status: VALIDATED

    Source sequence(s)
    AL133453
    Conserved Domains (1) summary
    pfam04137
    Location:60 → 387
    ERO1; Endoplasmic Reticulum Oxidoreductin 1 (ERO1)

  12. NM_001382475.1 → NP_001369404.1  ERO1-like protein alpha isoform 13 precursor

    Status: VALIDATED

    Source sequence(s)
    AL133453
    Conserved Domains (1) summary
    pfam04137
    Location:60 → 375
    ERO1; Endoplasmic Reticulum Oxidoreductin 1 (ERO1)

  13. NM_001382476.1 → NP_001369405.1  ERO1-like protein alpha isoform 14 precursor

    Status: VALIDATED

    Source sequence(s)
    AL133453
    Conserved Domains (1) summary
    pfam04137
    Location:60 → 370
    ERO1; Endoplasmic Reticulum Oxidoreductin 1 (ERO1)

  14. NM_014584.3 → NP_055399.1  ERO1-like protein alpha isoform 2 precursor

    See identical proteins and their annotated locations for NP_055399.1

    Status: VALIDATED

    Source sequence(s)
    AL133453, BC012941
    Consensus CDS
    CCDS9709.1
    UniProtKB/Swiss-Prot
    A8K9X4, A8MYW1, Q7LD45, Q96HE7, Q9P1Q9, Q9UKV6
    Related
    ENSP00000379042.3, ENST00000395686.8
    Conserved Domains (1) summary
    pfam04137
    Location:60 → 455
    ERO1; Endoplasmic Reticulum Oxidoreductin 1 (ERO1)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    52639915..52695558 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    46847757..46903365 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96HE7.2 GenPept UniProtKB/Swiss-Prot:Q96HE7

Gene LinkOut

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