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Gfus GDP-L-fucose synthase [ Rattus norvegicus (Norway rat) ]

Gene ID: 300036, updated on 6-Jun-2024

Summary

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Official Symbol
Gfusprovided by RGD
Official Full Name
GDP-L-fucose synthaseprovided by RGD
Primary source
RGD:1307028
See related
Ensembl:ENSRNOG00000009020 AllianceGenome:RGD:1307028
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Tsta3
Summary
Predicted to enable GDP-L-fucose synthase activity; GDP-mannose 3,5-epimerase activity; and identical protein binding activity. Predicted to be involved in nucleotide-sugar metabolic process; positive regulation of endothelial cell migration; and positive regulation of endothelial cell-matrix adhesion via fibronectin. Predicted to act upstream of or within T cell mediated cytotoxicity. Orthologous to human GFUS (GDP-L-fucose synthase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 225.4), Kidney (RPKM 194.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Gfus in Genome Data Viewer
Location:
7q34
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (109492808..109497719, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (107612087..107617005, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (116958427..116963281, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene eukaryotic translation elongation factor 1 delta Neighboring gene tigger transposable element derived 5 Neighboring gene pyrroline-5-carboxylate reductase 3 Neighboring gene zinc finger protein 623 Neighboring gene uncharacterized LOC120093815 Neighboring gene zinc finger protein 707-like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The crystal structure of human GDP-L-fucose synthase. Zhou H, et al. Acta Biochim Biophys Sin (Shanghai), 2013 Sep. PMID 23774504
  2. Synthesis of GDP-L-fucose by the human FX protein. Tonetti M, et al. J Biol Chem, 1996 Nov 1. PMID 8910301
  3. Structure of the gene of tum- transplantation antigen P91A: the mutated exon encodes a peptide recognized with Ld by cytolytic T cells. Lurquin C, et al. Cell, 1989 Jul 28. PMID 2568889
  4. Involvement of alpha 1-2-fucosyltransferase I (FUT1) and surface-expressed Lewis(y) (CD174) in first endothelial cell-cell contacts during angiogenesis. Moehler TM, et al. J Cell Physiol, 2008 Apr. PMID 18205178
  5. Molecular cloning of human GDP-mannose 4,6-dehydratase and reconstitution of GDP-fucose biosynthesis in vitro. Sullivan FX, et al. J Biol Chem, 1998 Apr 3. PMID 9525924

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GDP-L-fucose synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GDP-L-fucose synthase activity ISO
Inferred from Sequence Orthology
more info
  
enables GDP-mannose 3,5-epimerase activity ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in 'de novo' GDP-L-fucose biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in 'de novo' GDP-L-fucose biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in GDP-mannose metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within T cell mediated cytotoxicity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of endothelial cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of endothelial cell-matrix adhesion via fibronectin ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
GDP-L-fucose synthase
Names
GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase
tissue specific transplantation antigen P35B
NP_001120927.1
NP_001257718.1
NP_001257719.1
XP_063119377.1
XP_063119378.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001127455.2 → NP_001120927.1  GDP-L-fucose synthase isoform a

    See identical proteins and their annotated locations for NP_001120927.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    BC158885, BF289545
    UniProtKB/TrEMBL
    A0A8I6A7C3, A6HS39
    Related
    ENSRNOP00000087082.1, ENSRNOT00000100492.1
    Conserved Domains (1) summary
    cd05239
    Location:9 → 312
    GDP_FS_SDR_e; GDP-fucose synthetase, extended (e) SDRs

  2. NM_001270789.1 → NP_001257718.1  GDP-L-fucose synthase isoform a

    See identical proteins and their annotated locations for NP_001257718.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    BC158885, BF289545, CA339313
    UniProtKB/TrEMBL
    A0A8I6A7C3, A6HS39
    Related
    ENSRNOP00000012306.5, ENSRNOT00000012306.8
    Conserved Domains (1) summary
    cd05239
    Location:9 → 312
    GDP_FS_SDR_e; GDP-fucose synthetase, extended (e) SDRs

  3. NM_001270790.1 → NP_001257719.1  GDP-L-fucose synthase isoform b

    See identical proteins and their annotated locations for NP_001257719.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    BC158885, BF289545
    UniProtKB/TrEMBL
    B0BNN0
    Related
    ENSRNOP00000071672.1, ENSRNOT00000082058.2
    Conserved Domains (2) summary
    cd05239
    Location:9 → 269
    GDP_FS_SDR_e; GDP-fucose synthetase, extended (e) SDRs
    pfam01370
    Location:10 → 202
    Epimerase; NAD dependent epimerase/dehydratase family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    109492808..109497719 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063263308.1 → XP_063119378.1  GDP-L-fucose synthase isoform X1

    UniProtKB/TrEMBL
    A0A8I6A7C3, A6HS39

  2. XM_063263307.1 → XP_063119377.1  GDP-L-fucose synthase isoform X1

    UniProtKB/TrEMBL
    A0A8I6A7C3, A6HS39

RNA

  1. XR_005486584.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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