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Ncaph2 non-SMC condensin II complex, subunit H2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 300149, updated on 17-Aug-2024

Summary

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Official Symbol
Ncaph2provided by RGD
Official Full Name
non-SMC condensin II complex, subunit H2provided by RGD
Primary source
RGD:1565937
See related
EnsemblRapid:ENSRNOG00000009598 AllianceGenome:RGD:1565937
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable chromatin binding activity. Predicted to be involved in meiotic chromosome condensation and nuclear division. Predicted to act upstream of or within T cell differentiation in thymus. Predicted to be located in several cellular components, including condensed chromosome; intercellular bridge; and nucleoplasm. Predicted to be part of condensin complex. Predicted to be active in chromosome and nucleus. Orthologous to human NCAPH2 (non-SMC condensin II complex subunit H2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 282.0), Liver (RPKM 245.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ncaph2 in Genome Data Viewer
Location:
7q34
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (122302550..122319570)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (120422926..120439942)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (130326597..130343655)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene lipase maturation factor 2 Neighboring gene thymidine phosphorylase Neighboring gene ciliary microtubule associated protein 1B Neighboring gene kelch domain containing 7B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A mutation in a chromosome condensin II subunit, kleisin beta, specifically disrupts T cell development. Gosling KM, et al. Proc Natl Acad Sci U S A, 2007 Jul 24. PMID 17640884, Free PMC Article
  2. Condensin II mutation causes T-cell lymphoma through tissue-specific genome instability. Woodward J, et al. Genes Dev, 2016 Oct 1. PMID 27737961, Free PMC Article
  3. Condensin confers the longitudinal rigidity of chromosomes. Houlard M, et al. Nat Cell Biol, 2015 Jun. PMID 25961503, Free PMC Article
  4. Mutations in genes encoding condensin complex proteins cause microcephaly through decatenation failure at mitosis. Martin CA, et al. Genes Dev, 2016 Oct 1. PMID 27737959, Free PMC Article
  5. Overlapping and non-overlapping functions of condensins I and II in neural stem cell divisions. Nishide K, et al. PLoS Genet, 2014 Dec. PMID 25474630, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC114417

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in T cell differentiation in thymus IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within T cell differentiation in thymus ISO
Inferred from Sequence Orthology
more info
  
involved_in chromosome condensation IEA
Inferred from Electronic Annotation
more info
  
involved_in female meiosis chromosome separation IEA
Inferred from Electronic Annotation
more info
  
involved_in female meiosis chromosome separation ISO
Inferred from Sequence Orthology
more info
  
involved_in female meiotic nuclear division ISO
Inferred from Sequence Orthology
more info
  
involved_in meiotic chromosome condensation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in meiotic chromosome condensation IEA
Inferred from Electronic Annotation
more info
  
involved_in meiotic chromosome condensation ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic chromosome condensation IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic chromosome condensation ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic chromosome condensation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mitotic sister chromatid separation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic sister chromatid separation IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic sister chromatid separation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of chromosome segregation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of chromosome segregation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of chromosome separation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of chromosome separation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell junction IEA
Inferred from Electronic Annotation
more info
  
located_in cell junction ISO
Inferred from Sequence Orthology
more info
  
is_active_in chromosome ISO
Inferred from Sequence Orthology
more info
  
located_in condensed chromosome ISO
Inferred from Sequence Orthology
more info
  
located_in condensed nuclear chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in condensed nuclear chromosome ISO
Inferred from Sequence Orthology
more info
  
part_of condensin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of condensin complex IEA
Inferred from Electronic Annotation
more info
  
part_of condensin complex ISO
Inferred from Sequence Orthology
more info
  
located_in intercellular bridge IEA
Inferred from Electronic Annotation
more info
  
located_in intercellular bridge ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
condensin-2 complex subunit H2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024877.2 → NP_001020048.1  condensin-2 complex subunit H2 isoform 2

    See identical proteins and their annotated locations for NP_001020048.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/Swiss-Prot
    Q4V8I2
    UniProtKB/TrEMBL
    A0A8L2QQZ1
    Related
    ENSRNOP00000052664.4, ENSRNOT00000055808.4
    Conserved Domains (3) summary
    pfam06278
    Location:1 → 73
    CNDH2_N; Condensin II complex subunit CAP-H2 or CNDH2, N-terminal
    pfam16858
    Location:255 → 536
    CNDH2_C; Condensin II complex subunit CAP-H2 or CNDH2, C-term
    pfam16869
    Location:97 → 207
    CNDH2_M; PF16858

  2. NM_001399741.1 → NP_001386670.1  condensin-2 complex subunit H2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/TrEMBL
    A0A0G2K4H8
    Related
    ENSRNOP00000073049.2, ENSRNOT00000084776.3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    122302550..122319570
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006242186.5 → XP_006242248.1  condensin-2 complex subunit H2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K4H8
    Conserved Domains (3) summary
    pfam06278
    Location:11 → 123
    CNDH2_N; Condensin II complex subunit CAP-H2 or CNDH2, N-terminal
    pfam16858
    Location:305 → 587
    CNDH2_C; Condensin II complex subunit CAP-H2 or CNDH2, C-term
    pfam16869
    Location:147 → 257
    CNDH2_M; PF16858

  2. XM_063263347.1 → XP_063119417.1  condensin-2 complex subunit H2 isoform X3

    UniProtKB/TrEMBL
    A0A8L2QQZ1
    Related
    ENSRNOP00000098486.2, ENSRNOT00000120877.2

  3. XM_006242188.5 → XP_006242250.1  condensin-2 complex subunit H2 isoform X2

    UniProtKB/TrEMBL
    A0A8L2QQZ1
    Conserved Domains (3) summary
    pfam06278
    Location:26 → 115
    CNDH2_N; Condensin II complex subunit CAP-H2 or CNDH2, N-terminal
    pfam16858
    Location:297 → 579
    CNDH2_C; Condensin II complex subunit CAP-H2 or CNDH2, C-term
    pfam16869
    Location:139 → 249
    CNDH2_M; PF16858
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q4V8I2.1 GenPept UniProtKB/Swiss-Prot:Q4V8I2

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