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Kctd17 potassium channel tetramerization domain containing 17 [ Rattus norvegicus (Norway rat) ]

Gene ID: 300317, updated on 2-Nov-2024

Summary

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Official Symbol
Kctd17provided by RGD
Official Full Name
potassium channel tetramerization domain containing 17provided by RGD
Primary source
RGD:1311154
See related
EnsemblRapid:ENSRNOG00000000231 AllianceGenome:RGD:1311154
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1311154
Summary
Predicted to enable cullin family protein binding activity; identical protein binding activity; and ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in endoplasmic reticulum calcium ion homeostasis; positive regulation of cilium assembly; and proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be located in endoplasmic reticulum. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in myoclonic dystonia 26. Orthologous to human KCTD17 (potassium channel tetramerization domain containing 17). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 72.6), Kidney (RPKM 35.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Kctd17 in Genome Data Viewer
Location:
7q34
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (111859556..111891869)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (109979060..110009091)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (119647301..119658148)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene thiosulfate sulfurtransferase Neighboring gene mercaptopyruvate sulfurtransferase Neighboring gene uncharacterized LOC120093822 Neighboring gene transmembrane serine protease 6 Neighboring gene uncharacterized LOC120093823 Neighboring gene interleukin 2 receptor subunit beta Neighboring gene C1q and TNF related 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A missense mutation in KCTD17 causes autosomal dominant myoclonus-dystonia. Mencacci NE, et al. Am J Hum Genet, 2015 Jun 4. PMID 25983243, Free PMC Article
  2. Ubiquitin-proteasome system controls ciliogenesis at the initial step of axoneme extension. Kasahara K, et al. Nat Commun, 2014 Oct 1. PMID 25270598, Free PMC Article
  3. Towards a proteome-scale map of the human protein-protein interaction network. Rual JF, et al. Nature, 2005 Oct 20. PMID 16189514
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cullin family protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cullin family protein binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-like ligase-substrate adaptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in endoplasmic reticulum calcium ion homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cilium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein homooligomerization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of Cul3-RING ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Cul3-RING ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
BTB/POZ domain-containing protein KCTD17
Names
potassium channel tetramerisation domain containing 17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001134529.1 → NP_001128001.1  BTB/POZ domain-containing protein KCTD17 isoform 2

    See identical proteins and their annotated locations for NP_001128001.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473950
    UniProtKB/TrEMBL
    A6HSK3, A6HSK4
    Conserved Domains (2) summary
    smart00225
    Location:32 → 131
    BTB; Broad-Complex, Tramtrack and Bric a brac
    pfam02214
    Location:33 → 121
    BTB_2; BTB/POZ domain

  2. NM_001395732.1 → NP_001382661.1  BTB/POZ domain-containing protein KCTD17 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/TrEMBL
    D3ZYQ0
    Related
    ENSRNOP00000044649.4, ENSRNOT00000046563.4
    Conserved Domains (1) summary
    cd18391
    Location:31 → 131
    BTB_POZ_KCTD17; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 17 (KCTD17)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    111859556..111891869
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006241976.5 → XP_006242038.2  BTB/POZ domain-containing protein KCTD17 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AKZ1
    Related
    ENSRNOP00000093901.2, ENSRNOT00000117512.2

  2. XM_039078951.1 → XP_038934879.1  BTB/POZ domain-containing protein KCTD17 isoform X6

    Conserved Domains (1) summary
    cd18391
    Location:31 → 131
    BTB_POZ_KCTD17; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 17 (KCTD17)

  3. XM_006241977.4 → XP_006242039.2  BTB/POZ domain-containing protein KCTD17 isoform X4

    UniProtKB/TrEMBL
    A0A8I5ZRW4, A6HSK0, A6HSK4
    Related
    ENSRNOP00000081151.2, ENSRNOT00000105459.2
    Conserved Domains (2) summary
    smart00225
    Location:32 → 131
    BTB; Broad-Complex, Tramtrack and Bric a brac
    pfam02214
    Location:33 → 121
    BTB_2; BTB/POZ domain

  4. XM_039078947.2 → XP_038934875.1  BTB/POZ domain-containing protein KCTD17 isoform X2

    Conserved Domains (1) summary
    cd18391
    Location:31 → 131
    BTB_POZ_KCTD17; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 17 (KCTD17)

  5. XM_039078948.2 → XP_038934876.1  BTB/POZ domain-containing protein KCTD17 isoform X3

    Conserved Domains (1) summary
    cd18391
    Location:31 → 131
    BTB_POZ_KCTD17; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 17 (KCTD17)

  6. XM_039078954.2 → XP_038934882.1  BTB/POZ domain-containing protein KCTD17 isoform X11

    UniProtKB/TrEMBL
    A0A8I5ZZ48, A6HSK4
    Conserved Domains (1) summary
    cd18391
    Location:31 → 131
    BTB_POZ_KCTD17; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 17 (KCTD17)

  7. XM_006241983.5 → XP_006242045.2  BTB/POZ domain-containing protein KCTD17 isoform X13

    UniProtKB/TrEMBL
    A6HSK1, A6HSK4
    Conserved Domains (2) summary
    smart00225
    Location:32 → 131
    BTB; Broad-Complex, Tramtrack and Bric a brac
    pfam02214
    Location:33 → 121
    BTB_2; BTB/POZ domain

  8. XM_039078949.2 → XP_038934877.1  BTB/POZ domain-containing protein KCTD17 isoform X5

    Conserved Domains (1) summary
    cd18391
    Location:31 → 131
    BTB_POZ_KCTD17; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 17 (KCTD17)

  9. XM_039078952.2 → XP_038934880.1  BTB/POZ domain-containing protein KCTD17 isoform X7

    Conserved Domains (1) summary
    cd18391
    Location:31 → 131
    BTB_POZ_KCTD17; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 17 (KCTD17)

  10. XM_039078953.2 → XP_038934881.1  BTB/POZ domain-containing protein KCTD17 isoform X10

    UniProtKB/TrEMBL
    A6HSK4
    Conserved Domains (1) summary
    cd18391
    Location:31 → 131
    BTB_POZ_KCTD17; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 17 (KCTD17)

  11. XM_063263392.1 → XP_063119462.1  BTB/POZ domain-containing protein KCTD17 isoform X10

  12. XM_063263391.1 → XP_063119461.1  BTB/POZ domain-containing protein KCTD17 isoform X9

  13. XM_006241978.5 → XP_006242040.2  BTB/POZ domain-containing protein KCTD17 isoform X8

    UniProtKB/TrEMBL
    A0A8I6A664
    Related
    ENSRNOP00000086871.1, ENSRNOT00000114366.2

  14. XM_039078955.2 → XP_038934883.1  BTB/POZ domain-containing protein KCTD17 isoform X14

    UniProtKB/TrEMBL
    A6HSK4
    Conserved Domains (1) summary
    cd18391
    Location:31 → 131
    BTB_POZ_KCTD17; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 17 (KCTD17)

  15. XM_063263393.1 → XP_063119463.1  BTB/POZ domain-containing protein KCTD17 isoform X12

Nucleotide Protein Strain
Heading Accession and Version

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