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slc39a7 solute carrier family 39 member 7 [ Danio rerio (zebrafish) ]

Gene ID: 30094, updated on 4-Jan-2025

Summary

Official Symbol
slc39a7provided by ZNC
Official Full Name
solute carrier family 39 member 7provided by ZNC
Primary source
ZFIN:ZDB-GENE-991110-20
See related
Ensembl:ENSDARG00000104451 AllianceGenome:ZFIN:ZDB-GENE-991110-20
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
ke4; HKE4; ZIP7; id:ibd5081; wu:fc28c09
Summary
Predicted to enable zinc ion transmembrane transporter activity. Acts upstream of or within intracellular zinc ion homeostasis. Predicted to be located in Golgi apparatus and endoplasmic reticulum membrane. Is expressed in brain; eye; gill; muscle; and optic cup. Human ortholog(s) of this gene implicated in agammaglobulinemia 9. Orthologous to human SLC39A7 (solute carrier family 39 member 7). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

See slc39a7 in Genome Data Viewer
Location:
chromosome: 19
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (18903559..18915935)
105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (19330589..19342982)

Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene palmitoyl-protein thioesterase 2b Neighboring gene microRNA 219-3 Neighboring gene uncharacterized LOC137488435 Neighboring gene uncharacterized LOC137488499

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

General gene information

Markers

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables metal ion transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables zinc ion transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Process Evidence Code Pubs
involved_in B cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in intracellular zinc ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within intracellular zinc ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intracellular zinc ion homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within metal ion transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of ferroptosis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in skin epidermis development ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in zinc ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within zinc ion transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
acts_upstream_of_or_within zinc ion transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within zinc ion transport ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
zinc transporter Slc39a7
Names
histidine-rich membrane protein Ke4
solute carrier family 39 (zinc transporter), member 7
zrt-, Irt-like protein 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_130931.3NP_571006.3  zinc transporter Slc39a7 precursor

    Status: VALIDATED

    Source sequence(s)
    EH509633, EH611820, FP067442
    UniProtKB/Swiss-Prot
    A3KPZ7, Q9PUB8
    UniProtKB/TrEMBL
    Q6DGU8
    Related
    ENSDARP00000130247.1, ENSDART00000166562.2
    Conserved Domains (1) summary
    pfam02535
    Location:122441
    Zip; ZIP Zinc transporter

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007130.7 Reference GRCz11 Primary Assembly

    Range
    18903559..18915935
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)