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Acy1 aminoacylase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 300981, updated on 10-Jul-2024

Summary

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Official Symbol
Acy1provided by RGD
Official Full Name
aminoacylase 1provided by RGD
Primary source
RGD:2030
See related
EnsemblRapid:ENSRNOG00000011189 AllianceGenome:RGD:2030
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Acy1a; Acy1b
Summary
Enables aminoacylase activity. Predicted to be involved in protein catabolic process. Predicted to be located in extracellular exosome. Orthologous to human ACY1 (aminoacylase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 2160.4), Liver (RPKM 244.3) and 1 other tissue See more
Orthologs
human mouse all
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Genomic context

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See Acy1 in Genome Data Viewer
Location:
8q32
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (115951068..115956471, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (107072354..107077756, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (115134792..115140171, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L29 Neighboring gene uncharacterized LOC120094254 Neighboring gene POC1 centriolar protein A Neighboring gene uncharacterized LOC134480228 Neighboring gene dual specificity phosphatase 7 Neighboring gene abhydrolase domain containing 14A Neighboring gene abhydrolase domain containing 14b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Acylase 1 expression in rat intestinal crypt--villus axis. Cigna N, et al. Cell Biol Int, 2007 Sep. PMID 17478110
  2. The rat kidney acylase 1. Evidence for a new cDNA form and comparisons with the porcine intestinal enzyme. Perrier J, et al. Comp Biochem Physiol B Biochem Mol Biol, 2004 Jul. PMID 15253876
  3. Rat kidney acylase I: further characterisation and mutation studies on the involvement of Glu 147 in the catalytic process. Durand A, et al. Biochimie, 2003 Oct. PMID 14644550
  4. The rat kidney acylase I, characterization and molecular cloning. Differences with other acylases I. Giardina T, et al. Eur J Biochem, 2000 Oct. PMID 11012679
  5. Comprehensive analysis of low-abundance proteins in human urinary exosomes using peptide ligand library technology, peptide OFFGEL fractionation and nanoHPLC-chip-MS/MS. Zhang Y, et al. Electrophoresis, 2010 Dec. PMID 21082674

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These findings proposed ACY 1 as a new marker transcript for absorbing cells of intestinal crypt, which can be used to monitor the process of intestinal N-alpha-acetylated protein metabolism.[ACY 1]
    Title: Acylase 1 expression in rat intestinal crypt--villus axis.
  2. active site characterization
    Title: Rat kidney acylase I: further characterisation and mutation studies on the involvement of Glu 147 in the catalytic process.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables aminoacylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables aminoacylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables aminoacylase activity IEA
Inferred from Electronic Annotation
more info
  
enables aminoacylase activity ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in amino acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in protein catabolic process TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular exosome IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular exosome ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
aminoacylase-1A
Names
ACY IA
ACY IB
ACY-1A
ACY-1B
N-acyl-L-amino-acid amidohydrolase
aminoacylase-1B
NP_001005383.2
NP_001380767.1
XP_063121307.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001005383.2 → NP_001005383.2  aminoacylase-1A

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/Swiss-Prot
    Q6AYS7, Q6PTT1
    UniProtKB/TrEMBL
    A0A8I5ZVF1
    Related
    ENSRNOP00000090917.2, ENSRNOT00000112946.2
    Conserved Domains (1) summary
    cd05646
    Location:9 → 399
    M20_AcylaseI_like; M20 Aminoacylase-I like subfamily

  2. NM_001393838.1 → NP_001380767.1  aminoacylase-1A

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/Swiss-Prot
    Q6AYS7, Q6PTT1
    UniProtKB/TrEMBL
    A0A8I5ZVF1
    Related
    ENSRNOP00000082264.2, ENSRNOT00000103409.2
    Conserved Domains (1) summary
    cd05646
    Location:9 → 399
    M20_AcylaseI_like; M20 Aminoacylase-I like subfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    115951068..115956471 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063265237.1 → XP_063121307.1  aminoacylase-1A isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZVF1
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6AYS7.1 GenPept UniProtKB/Swiss-Prot:Q6AYS7
Q6PTT0.1 GenPept UniProtKB/Swiss-Prot:Q6PTT0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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