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Slc25a23 solute carrier family 25 member 23 [ Rattus norvegicus (Norway rat) ]

Gene ID: 301113, updated on 2-Nov-2024

Summary

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Official Symbol
Slc25a23provided by RGD
Official Full Name
solute carrier family 25 member 23provided by RGD
Primary source
RGD:1588586
See related
EnsemblRapid:ENSRNOG00000047781 AllianceGenome:RGD:1588586
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable ADP:phosphate antiporter activity and ATP:phosphate antiporter activity. Predicted to be involved in several processes, including calcium import into the mitochondrion; positive regulation of mitochondrial calcium ion concentration; and purine ribonucleotide transport. Predicted to act upstream of or within several processes, including adenine nucleotide transport; cellular response to calcium ion; and regulation of oxidative phosphorylation. Predicted to be located in mitochondrion. Orthologous to human SLC25A23 (solute carrier family 25 member 23). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 252.3), Liver (RPKM 238.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Slc25a23 in Genome Data Viewer
Location:
9q11
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (1969633..1985365, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (1882636..1898369, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (9987988..10003599)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene adenylate kinase isoenzyme 5 Neighboring gene KH-type splicing regulatory protein Neighboring gene solute carrier family 25, member 41 Neighboring gene crumbs cell polarity complex component 3 Neighboring gene DENN domain containing 1C

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. SLC25A23 augments mitochondrial Ca²⁺ uptake, interacts with MCU, and induces oxidative stress-mediated cell death. Hoffman NE, et al. Mol Biol Cell, 2014 Mar. PMID 24430870, Free PMC Article
  2. Glucagon regulation of oxidative phosphorylation requires an increase in matrix adenine nucleotide content through Ca2+ activation of the mitochondrial ATP-Mg/Pi carrier SCaMC-3. Amigo I, et al. J Biol Chem, 2013 Mar 15. PMID 23344948, Free PMC Article
  3. Identification of EFHD1 as a novel Ca(2+) sensor for mitoflash activation. Hou T, et al. Cell Calcium, 2016 May. PMID 26975899
  4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ADP:phosphate antiporter activity ISO
Inferred from Sequence Orthology
more info
  
enables ATP transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP:phosphate antiporter activity ISO
Inferred from Sequence Orthology
more info
  
enables adenine nucleotide transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in ADP transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ATP transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within adenine nucleotide transport ISO
Inferred from Sequence Orthology
more info
  
involved_in adenine nucleotide transport ISO
Inferred from Sequence Orthology
more info
  
involved_in calcium import into the mitochondrion ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cellular response to calcium ion ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrial ATP transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrial calcium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of mitochondrial calcium ion concentration ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cellular hyperosmotic salinity response ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of cellular respiration ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of oxidative phosphorylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of sequestering of calcium ion ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within renal system process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
mitochondrial adenyl nucleotide antiporter SLC25A23
Names
calcium-binding mitochondrial carrier protein SCaMC-3
phosphate carrier), member 23
solute carrier family 25 (mitochondrial carrier
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106873.3 → NP_001100343.1  mitochondrial adenyl nucleotide antiporter SLC25A23

    See identical proteins and their annotated locations for NP_001100343.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/TrEMBL
    A0A0G2JVD2, A6KQS8
    Related
    ENSRNOP00000069437.2, ENSRNOT00000086575.3
    Conserved Domains (2) summary
    COG5126
    Location:7 → 142
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    PTZ00169
    Location:189 → 462
    PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    1969633..1985365 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039083133.2 → XP_038939061.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X2

    Conserved Domains (3) summary
    COG5126
    Location:7 → 142
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    PTZ00169
    Location:189 → 426
    PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
    pfam00153
    Location:184 → 267
    Mito_carr; Mitochondrial carrier protein

  2. XM_017596319.3 → XP_017451808.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X1

    UniProtKB/TrEMBL
    M0R4V4
    Related
    ENSRNOP00000064402.2, ENSRNOT00000073000.4
Nucleotide Protein Strain
Heading Accession and Version

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