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Mfsd6 major facilitator superfamily domain containing 6 [ Rattus norvegicus (Norway rat) ]

Gene ID: 301388, updated on 2-Nov-2024

Summary

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Official Symbol
Mfsd6provided by RGD
Official Full Name
major facilitator superfamily domain containing 6provided by RGD
Primary source
RGD:1562317
See related
EnsemblRapid:ENSRNOG00000012663 AllianceGenome:RGD:1562317
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1562317
Summary
Predicted to enable MHC class I protein binding activity and MHC class I receptor activity. Predicted to be involved in antigen processing and presentation of exogenous peptide antigen via MHC class I. Predicted to be active in plasma membrane. Orthologous to human MFSD6 (major facilitator superfamily domain containing 6). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 75.0), Liver (RPKM 54.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mfsd6 in Genome Data Viewer
Location:
9q22
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (56265152..56350449)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (48773171..48858471)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (53626412..53710820)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene post-GPI attachment to proteins 2, pseudogene 2 Neighboring gene BCL2 interacting protein 3, pseudogene 1 Neighboring gene nuclear envelope integral membrane protein 2 Neighboring gene developmental pluripotency-associated protein 3-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Macrophage MHC receptor 2: a novel receptor on allograft (H-2D(d)K(d))-induced macrophage (H-2D(b)K(b)) recognizing an MHC class I molecule, H-2K(d), in mice. Tashiro-Yamaji J, et al. Gene, 2006 Dec 15. PMID 17010536
  2. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables MHC class I protein binding ISO
Inferred from Sequence Orthology
more info
  
enables MHC class I receptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in antigen processing and presentation of exogenous peptide antigen via MHC class I IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within antigen processing and presentation of exogenous peptide antigen via MHC class I ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
major facilitator superfamily domain-containing protein 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106911.2 → NP_001100381.1  major facilitator superfamily domain-containing protein 6 isoform 1

    See identical proteins and their annotated locations for NP_001100381.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/TrEMBL
    A0A0G2JW92, A6INV8, D3ZCJ3
    Related
    ENSRNOP00000036787.4, ENSRNOT00000031267.8
    Conserved Domains (4) summary
    cd06174
    Location:453 → 623
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam07690
    Location:453 → 651
    MFS_1; Major Facilitator Superfamily
    pfam12832
    Location:68 → 143
    MFS_1_like; MFS_1 like family
    pfam16038
    Location:366 → 395
    TMIE; TMIE protein

  2. NM_001432455.1 → NP_001419384.1  major facilitator superfamily domain-containing protein 6 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/TrEMBL
    A6INV8, D3ZCJ3

  3. NM_001432456.1 → NP_001419385.1  major facilitator superfamily domain-containing protein 6 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/TrEMBL
    A0A8I6ALE1

  4. NM_001432457.1 → NP_001419386.1  major facilitator superfamily domain-containing protein 6 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/TrEMBL
    A0A8I6ALE1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    56265152..56350449
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006244898.5 → XP_006244960.1  major facilitator superfamily domain-containing protein 6 isoform X2

    Conserved Domains (4) summary
    cd06174
    Location:453 → 623
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam07690
    Location:453 → 651
    MFS_1; Major Facilitator Superfamily
    pfam12832
    Location:68 → 143
    MFS_1_like; MFS_1 like family
    pfam16038
    Location:366 → 395
    TMIE; TMIE protein

  2. XM_063266940.1 → XP_063123010.1  major facilitator superfamily domain-containing protein 6 isoform X2

    Related
    ENSRNOP00000094609.1, ENSRNOT00000104195.2

  3. XM_017596349.3 → XP_017451838.1  major facilitator superfamily domain-containing protein 6 isoform X1

    Related
    ENSRNOP00000069791.2, ENSRNOT00000083487.3
    Conserved Domains (4) summary
    cd06174
    Location:453 → 623
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam07690
    Location:453 → 651
    MFS_1; Major Facilitator Superfamily
    pfam12832
    Location:68 → 143
    MFS_1_like; MFS_1 like family
    pfam16038
    Location:366 → 395
    TMIE; TMIE protein

  4. XM_006244897.5 → XP_006244959.1  major facilitator superfamily domain-containing protein 6 isoform X1

    See identical proteins and their annotated locations for XP_006244959.1

    UniProtKB/TrEMBL
    A0A0G2JW92, A6INV8, D3ZCJ3
    Conserved Domains (4) summary
    cd06174
    Location:453 → 623
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam07690
    Location:453 → 651
    MFS_1; Major Facilitator Superfamily
    pfam12832
    Location:68 → 143
    MFS_1_like; MFS_1 like family
    pfam16038
    Location:366 → 395
    TMIE; TMIE protein
Nucleotide Protein Strain
Heading Accession and Version

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