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nup93 nucleoporin 93 [ Danio rerio (zebrafish) ]

Gene ID: 30172, updated on 2-Nov-2024

Summary

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Official Symbol
nup93provided by ZNC
Official Full Name
nucleoporin 93provided by ZNC
Primary source
ZFIN:ZDB-GENE-990415-46
See related
Ensembl:ENSDARG00000003487 AllianceGenome:ZFIN:ZDB-GENE-990415-46
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
dye
Summary
Predicted to be a structural constituent of nuclear pore. Predicted to be involved in nuclear pore complex assembly; poly(A)+ mRNA export from nucleus; and protein import into nucleus. Predicted to act upstream of or within mRNA transport and protein transport. Predicted to be located in nuclear membrane and nuclear periphery. Predicted to be part of nuclear pore. Human ortholog(s) of this gene implicated in nephrotic syndrome type 12. Orthologous to human NUP93 (nucleoporin 93). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See nup93 in Genome Data Viewer
Location:
chromosome: 18
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (17531535..17577489)
105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (17542462..17588918)

Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9 Neighboring gene Bardet-Biedl syndrome 2 Neighboring gene metallothionein 2 Neighboring gene microRNA 138 Neighboring gene solute carrier family 12 member 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Insertional mutagenesis in zebrafish identifies two novel genes, pescadillo and dead eye, essential for embryonic development. Allende ML, et al. Genes Dev, 1996 Dec 15. PMID 8985183
  2. Localization of genes encoding metallothionein-like protein (mt2 and smtb) in the brain of zebrafish. Teoh SL, et al. J Chem Neuroanat, 2015 Dec. PMID 26571427
  3. A Toolbox for Efficient Proximity-Dependent Biotinylation in Zebrafish Embryos. Rosenthal SM, et al. Mol Cell Proteomics, 2021. PMID 34332124, Free PMC Article
  4. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables structural constituent of nuclear pore IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of nuclear pore IEA
Inferred from Electronic Annotation
more info
  
enables structural constituent of nuclear pore ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within mRNA transport IEA
Inferred from Electronic Annotation
more info
  
involved_in nuclear pore complex assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in poly(A)+ mRNA export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nuclear periphery ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of nuclear pore IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of nuclear pore IEA
Inferred from Electronic Annotation
more info
  
part_of nuclear pore ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
nuclear pore complex protein Nup93
Names
93 kDa nucleoporin
dead eye protein
nucleoporin Nup93

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_130981.2 → NP_571056.2  nuclear pore complex protein Nup93

    See identical proteins and their annotated locations for NP_571056.2

    Status: PROVISIONAL

    Source sequence(s)
    BC044466
    UniProtKB/Swiss-Prot
    P79740, Q7ZU29, Q9DGQ8
    UniProtKB/TrEMBL
    B2GRL6
    Related
    ENSDARP00000013627.7, ENSDART00000025782.9
    Conserved Domains (2) summary
    pfam04097
    Location:220 → 804
    Nic96; Nup93/Nic96
    cl14813
    Location:4 → 127
    GluZincin; Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007129.7 Reference GRCz11 Primary Assembly

    Range
    17531535..17577489
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009293522.3 → XP_009291797.1  nuclear pore complex protein Nup93 isoform X1

    UniProtKB/TrEMBL
    A0A8M3B2U6, Q1LV08
    Conserved Domains (2) summary
    pfam04097
    Location:220 → 804
    Nic96; Nup93/Nic96
    cl14813
    Location:4 → 127
    GluZincin; Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)

  2. XM_009293523.4 → XP_009291798.1  nuclear pore complex protein Nup93 isoform X2

    UniProtKB/TrEMBL
    A0A8M3AKC1
    Conserved Domains (1) summary
    pfam04097
    Location:88 → 672
    Nic96; Nup93/Nic96

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018395018.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    426111..458311
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7ZU29.1 GenPept UniProtKB/Swiss-Prot:Q7ZU29

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