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mafba MAF bZIP transcription factor Ba [ Danio rerio (zebrafish) ]

Gene ID: 30210, updated on 14-Nov-2024

Summary

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Official Symbol
mafbaprovided by ZNC
Official Full Name
MAF bZIP transcription factor Baprovided by ZNC
Primary source
ZFIN:ZDB-GENE-980526-515
See related
Ensembl:ENSDARG00000017121 AllianceGenome:ZFIN:ZDB-GENE-980526-515
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
kr; val; krml; mafb; kreisler; wu:fc22d11; wu:fj82a09
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including hindbrain development; pronephric glomerulus development; and retinal rod cell development. Predicted to be active in nucleus. Is expressed in several structures, including hindbrain neural keel; nervous system; neural plate; renal system; and vein. Human ortholog(s) of this gene implicated in Duane retraction syndrome and multicentric carpotarsal osteolysis syndrome. Orthologous to human MAFB (MAF bZIP transcription factor B). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See mafba in Genome Data Viewer
Location:
chromosome: 23
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (3405665..3409140, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (3462555..3466030, complement)

Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene DEAH-box helicase 35 Neighboring gene uncharacterized LOC137489067 Neighboring gene ring finger protein 114 Neighboring gene spermatogenesis associated 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Transgenic zebrafish recapitulating tbx16 gene early developmental expression. Wells S, et al. PLoS One, 2011. PMID 21720556, Free PMC Article
  2. Dissection of the adult zebrafish kidney. Gerlach GF, et al. J Vis Exp, 2011 Aug 29. PMID 21897357, Free PMC Article
  3. A Gal4/UAS system for conditional transgene expression in rhombomere 4 of the zebrafish hindbrain. Choe SK, et al. Dev Dyn, 2012 Jun. PMID 22499412, Free PMC Article
  4. Paralog group 1 hox genes regulate rhombomere 5/6 expression of vhnf1, a repressor of rostral hindbrain fates, in a meis-dependent manner. Choe SK, et al. Dev Biol, 2004 Jul 15. PMID 15223339
  5. Zebrafish deadly seven functions in neurogenesis. Gray M, et al. Dev Biol, 2001 Sep 15. PMID 11543616

See all (109) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mafba and Mafbb regulate microglial colonization of zebrafish brain via controlling chemotaxis receptor expression.
    Title: Mafba and Mafbb regulate microglial colonization of zebrafish brain via controlling chemotaxis receptor expression.
  2. Vegfc signaling increases mafba expression to control downstream transcription
    Title: mafba is a downstream transcriptional effector of Vegfc signaling essential for embryonic lymphangiogenesis in zebrafish.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within abducens nucleus development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within anterior/posterior pattern specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within embryonic pattern specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within ionocyte differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within lymphangiogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within pronephric glomerulus development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within retinal rod cell development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within rhombomere 5 development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within rhombomere 6 development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within rhombomere boundary formation IMP
Inferred from Mutant Phenotype
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transcription factor MafB
Names
maf-B
transcription factor Val
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog Ba
v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B
valentino

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131015.3 → NP_571090.2  transcription factor MafB

    Status: VALIDATED

    Source sequence(s)
    CABZ01028915
    UniProtKB/Swiss-Prot
    O73679, Q98UK5
    UniProtKB/TrEMBL
    A0A2U3TVD3, A0A8M1PB55
    Related
    ENSDARP00000018087.6, ENSDART00000002309.8
    Conserved Domains (2) summary
    cd14718
    Location:306 → 375
    bZIP_Maf_large; Basic leucine zipper (bZIP) domain of large musculoaponeurotic fibrosarcoma (Maf) proteins: a DNA-binding and dimerization domain
    pfam08383
    Location:122 → 157
    Maf_N; Maf N-terminal region

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007134.7 Reference GRCz11 Primary Assembly

    Range
    3405665..3409140 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q98UK5.1 GenPept UniProtKB/Swiss-Prot:Q98UK5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.