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en2b engrailed homeobox 2b [ Danio rerio (zebrafish) ]

Gene ID: 30238, updated on 2-Nov-2024

Summary

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Official Symbol
en2bprovided by ZNC
Official Full Name
engrailed homeobox 2bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-980526-40
See related
Ensembl:ENSDARG00000038868 AllianceGenome:ZFIN:ZDB-GENE-980526-40
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
en3; eng3; ENG-3; eng2b; ZF-EN-1
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within cell fate specification; midbrain development; and midbrain-hindbrain boundary development. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; mandibular muscle; midbrain hindbrain boundary neural plate; midbrain hindbrain boundary neural rod; and neural keel. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human EN2 (engrailed homeobox 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See en2b in Genome Data Viewer
Location:
chromosome: 2
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (29976435..29979956)
105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (29992902..29996423)

Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene PAX interacting (with transcription-activation domain) protein 1 Neighboring gene 5-hydroxytryptamine (serotonin) receptor 5A, genome duplicate a Neighboring gene canopy FGF signaling regulator 1 Neighboring gene RNA binding motif protein 33b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. H(2)O(2) and Engrailed 2 paracrine activity synergize to shape the zebrafish optic tectum. Amblard I, et al. Commun Biol, 2020 Sep 29. PMID 32994473, Free PMC Article
  2. The ELF-97 alkaline phosphatase substrate provides a bright, photostable, fluorescent signal amplification method for FISH. Paragas VB, et al. J Histochem Cytochem, 1997 Mar. PMID 9071316
  3. Characterization of three novel members of the zebrafish Pax2/5/8 family: dependency of Pax5 and Pax8 expression on the Pax2.1 (noi) function. Pfeffer PL, et al. Development, 1998 Aug. PMID 9671580
  4. Formation of the zebrafish midbrain-hindbrain boundary constriction requires laminin-dependent basal constriction. Gutzman JH, et al. Mech Dev, 2008 Nov-Dec. PMID 18682291, Free PMC Article
  5. Diversity of expression of engrailed-like antigens in zebrafish. Hatta K, et al. Development, 1991 Jul. PMID 1682127

See all (61) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within anterior/posterior pattern specification IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within cell fate specification IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within midbrain development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within midbrain-hindbrain boundary development IGI
Inferred from Genetic Interaction
more info
  
involved_in neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
homeobox protein engrailed-2b
Names
engrailed 2b
engrailed 3
homeobox protein en-2b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131040.1 → NP_571115.1  homeobox protein engrailed-2b

    See identical proteins and their annotated locations for NP_571115.1

    Status: PROVISIONAL

    Source sequence(s)
    X68447
    UniProtKB/Swiss-Prot
    P31533
    Related
    ENSDARP00000056747.3, ENSDART00000056748.4
    Conserved Domains (2) summary
    pfam00046
    Location:175 → 228
    Homeobox; Homeobox domain
    pfam10525
    Location:230 → 259
    Engrail_1_C_sig; Engrailed homeobox C-terminal signature domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007113.7 Reference GRCz11 Primary Assembly

    Range
    29976435..29979956
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P31533.2 GenPept UniProtKB/Swiss-Prot:P31533

Gene LinkOut

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