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prph peripherin [ Danio rerio (zebrafish) ]

Gene ID: 30259, updated on 14-Nov-2024

Summary

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Official Symbol
prphprovided by ZNC
Official Full Name
peripherinprovided by ZNC
Primary source
ZFIN:ZDB-GENE-990415-207
See related
Ensembl:ENSDARG00000028306 AllianceGenome:ZFIN:ZDB-GENE-990415-207
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
plasticin; zgc:111926
Summary
Predicted to enable structural molecule activity. Acts upstream of or within tissue regeneration. Predicted to be located in intermediate filament. Predicted to be active in axon; plasma membrane; and type III intermediate filament. Is expressed in nervous system. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 1. Orthologous to human PRPH (peripherin). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See prph in Genome Data Viewer
Location:
chromosome: 11
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (3320598..3334248, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (3252438..3266088, complement)

Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene cyclin dependent kinase 2 Neighboring gene SAP domain containing ribonucleoprotein Neighboring gene tubulin, alpha 2 Neighboring gene sulfite oxidase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Gefiltin in zebrafish embryos: sequential gene expression of two neurofilament proteins in retinal ganglion cells. Leake D, et al. Differentiation, 1999 Dec. PMID 10653354
  2. Developmental pattern of the neuronal intermediate filament inaa in the zebrafish retina. Liao ML, et al. J Comp Neurol, 2016 Dec 15. PMID 27159642
  3. Gene expression profiles of intact and regenerating zebrafish retina. Cameron DA, et al. Mol Vis, 2005 Sep 20. PMID 16205622
  4. The Autotaxin-Lysophosphatidic Acid Axis Modulates Histone Acetylation and Gene Expression during Oligodendrocyte Differentiation. Wheeler NA, et al. J Neurosci, 2015 Aug 12. PMID 26269646, Free PMC Article
  5. FGF and canonical Wnt signaling cooperate to induce paraxial mesoderm from tailbud neuromesodermal progenitors through regulation of a two-step epithelial to mesenchymal transition. Goto H, et al. Development, 2017 Apr 15. PMID 28242612, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables structural constituent of cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural molecule activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in intermediate filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within tissue regeneration IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in intermediate filament IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in type III intermediate filament IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
peripherin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001319237.1 → NP_001306166.1  peripherin

    Status: VALIDATED

    Source sequence(s)
    CU633810, FO704600
    UniProtKB/TrEMBL
    A0A8M1P836, Q502Q7
    Related
    ENSDARP00000129087.1, ENSDART00000154314.3
    Conserved Domains (3) summary
    pfam00038
    Location:72 → 385
    Filament; Intermediate filament protein
    pfam04732
    Location:1 → 71
    Filament_head; Intermediate filament head (DNA binding) region
    cl12013
    Location:178 → 352
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007122.7 Reference GRCz11 Primary Assembly

    Range
    3320598..3334248 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_131054.1: Suppressed sequence

    Description
    NM_131054.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version

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