jak2a Janus kinase 2a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: jak2aprovided by ZNC
Official Full Name: Janus kinase 2aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-980526-481
See related: Ensembl:ENSDARG00000104808 AllianceGenome:ZFIN:ZDB-GENE-980526-481
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: jak4
Summary: Predicted to enable growth hormone receptor binding activity and non-membrane spanning protein tyrosine kinase activity. Acts upstream of or within several processes, including cell surface receptor signaling pathway via JAK-STAT; hemopoiesis; and positive regulation of receptor signaling pathway via JAK-STAT. Predicted to be located in cytoskeleton; endomembrane system; and membrane. Predicted to be active in cytosol. Is expressed in several structures, including cardiovascular system; erythroblast; hematopoietic system; nervous system; and yolk. Human ortholog(s) of this gene implicated in several diseases, including gastrointestinal system cancer (multiple); hematologic cancer (multiple); hepatic vascular disease (multiple); inflammatory bowel disease (multiple); and lung non-small cell carcinoma (multiple). Orthologous to human JAK2 (Janus kinase 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 21

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	21	NC_007132.7 (249945..269898)
105	previous assembly	GRCz10 (GCF_000002035.5)	21	NC_007132.6 (228374..248446)

Chromosome 21 - NC_007132.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

our data indicate that Jak2a plays an important role in erythropoiesis and myeloid hematopoiesis
Title: Jak2a regulates erythroid and myeloid hematopoiesis during zebrafish embryogenesis.
Studies demonstrate a conserved role for SOCS1 in T cell development and suggest a novel T cell-independent function in embryonic myelopoiesis mediated, at least in part, via its effects on receptors using the Jak2-Stat5 pathway.
Title: Suppressor of cytokine signaling 1 regulates embryonic myelopoiesis independently of its effects on T cell development.
Of two Jak2 paralogues present in zebrafish, Jak2a but not Jak2b is involved in the intracellular transmission of the Ifn-gamma signal.
Title: In vivo analysis of Ifn-γ1 and Ifn-γ2 signaling in zebrafish.
The zebrafish jak2a(V581F) model shared many features with human PV and might provide mechanistic insights of this disease.
Title: A novel zebrafish jak2a(V581F) model shared features of human JAK2(V617F) polycythemia vera.
These data indicate that zebrafish Jak2a is important in both definitive hematopoiesis and blood vessel formation.
Title: Zebrafish Jak2a plays a crucial role in definitive hematopoiesis and blood vessel formation.

Submit: New GeneRIF Correction

General gene information

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Markers

fb55b03.x1 (e-PCR)
- UniSTS:190723

fc11e05.y1 (e-PCR)
- UniSTS:192519

G45043 (e-PCR)
- UniSTS:105845

G45579 (e-PCR)
- UniSTS:106381

G39309 (e-PCR)
- UniSTS:53142

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables growth hormone receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables non-membrane spanning protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables non-membrane spanning protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within blood vessel morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor signaling pathway via JAK-STAT	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell surface receptor signaling pathway via JAK-STAT	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cytokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within erythrocyte differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within erythrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in growth hormone receptor signaling pathway via JAK-STAT	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within intracellular signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of receptor signaling pathway via JAK-STAT	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within primitive hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein phosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in endomembrane system	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: tyrosine-protein kinase JAK2a

Names: Jak2a kinase; TEL/JAK2 fusion protein

NP_571168.1

EC 2.7.1.112

XP_009293332.1

EC 2.7.1.112

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131093.1 → NP_571168.1 tyrosine-protein kinase JAK2a

See identical proteins and their annotated locations for NP_571168.1

Status: PROVISIONAL

Source sequence(s)

AJ005690

UniProtKB/TrEMBL

O93596

Related

ENSDARP00000132483.1, ENSDART00000169026.2

Conserved Domains (7) summary

smart00219
Location:812 → 1084

TyrKc; Tyrosine kinase, catalytic domain

cd10379
Location:352 → 448

SH2_Jak2; Src homology 2 (SH2) domain in the Janus kinase 2 (Jak2) proteins

smart00295
Location:20 → 247

B41; Band 4.1 homologues

cd13333
Location:243 → 352

FERM_C_JAK2; FERM domain C-lobe of Janus kinase (JAK) 2

cd14205
Location:807 → 1090

PTKc_Jak2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 2

pfam07714
Location:509 → 769

Pkinase_Tyr; Protein tyrosine kinase

cl21453
Location:509 → 770

PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007132.7 Reference GRCz11 Primary Assembly

Range

249945..269898

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_009295057.4 → XP_009293332.1 tyrosine-protein kinase JAK2a isoform X1

UniProtKB/TrEMBL

A0A8M3ATI4, F1QWX8

Conserved Domains (7) summary

smart00219
Location:812 → 1084

TyrKc; Tyrosine kinase, catalytic domain

cd10379
Location:352 → 448

SH2_Jak2; Src homology 2 (SH2) domain in the Janus kinase 2 (Jak2) proteins

smart00295
Location:20 → 247

B41; Band 4.1 homologues

cd13333
Location:243 → 352

FERM_C_JAK2; FERM domain C-lobe of Janus kinase (JAK) 2

cd14205
Location:807 → 1090

PTKc_Jak2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 2

pfam07714
Location:509 → 769

Pkinase_Tyr; Protein tyrosine kinase

cl21453
Location:509 → 770

PKc_like; Protein Kinases, catalytic domain