pou6f1 POU class 6 homeobox 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: pou6f1provided by ZNC
Official Full Name: POU class 6 homeobox 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-980526-530
See related: Ensembl:ENSDARG00000011570 AllianceGenome:ZFIN:ZDB-GENE-980526-530
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: pouc; pou[c]
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within atrioventricular canal morphogenesis. Predicted to be located in nucleus. Is expressed in atrioventricular canal; atrium; cardiac ventricle; central nervous system; and telencephalon. Orthologous to human POU6F1 (POU class 6 homeobox 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 23

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	23	NC_007134.7 (33682516..33710012, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	23	NC_007134.6 (33756022..33783579, complement)

Chromosome 23 - NC_007134.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

We find that pouC is a multi-functional transcriptional regulator containing separable activation, repression, protein-protein interaction, and DNA binding domains. Using zebrafish heart development as a model system, we demonstrate that pouC knockdown impairs cardiac morphogenesis and affects cardiovascular function. We also find that levels of pouC expression must be fine-tuned to enable proper heart formation.
Title: pouC Regulates Expression of bmp4 During Atrioventricular Canal Formation in Zebrafish.

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General gene information

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Markers

pouc (e-PCR), detects polymorphism
- UniSTS:205442

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within atrioventricular canal morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: POU domain, class 6, transcription factor 1

Names: POU domain gene C; POU domain protein C; ZFPOU[C]

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131113.1 → NP_571188.1 POU domain, class 6, transcription factor 1

See identical proteins and their annotated locations for NP_571188.1

Status: PROVISIONAL

Source sequence(s)

X68432

UniProtKB/Swiss-Prot

B3DFR1, P31367

Related

ENSDARP00000111302.2, ENSDART00000130338.4

Conserved Domains (2) summary

smart00352
Location:448 → 522

POU; Found in Pit-Oct-Unc transcription factors

pfam00046
Location:546 → 599

Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007134.7 Reference GRCz11 Primary Assembly

Range

33682516..33710012 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005162296.5 → XP_005162353.1 POU domain, class 6, transcription factor 1 isoform X2

UniProtKB/TrEMBL

A0A2R8QIA3, A0A8M2B962

Related

ENSDARP00000151917.1, ENSDART00000187413.1

Conserved Domains (2) summary

smart00352
Location:433 → 507

POU; Found in Pit-Oct-Unc transcription factors

pfam00046
Location:531 → 584

Homeobox; Homeobox domain
XM_068216663.1 → XP_068072764.1 POU domain, class 6, transcription factor 1 isoform X1
XM_017353502.3 → XP_017208991.1 POU domain, class 6, transcription factor 1 isoform X3

UniProtKB/TrEMBL

A0A8M6Z4C6