fzd7b frizzled class receptor 7b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: fzd7bprovided by ZNC
Official Full Name: frizzled class receptor 7bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-990415-229
See related: Ensembl:ENSDARG00000027589 AllianceGenome:ZFIN:ZDB-GENE-990415-229
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fz13; fz7a; fz7b; zg13; fb38g02; fc44b09; wu:fb38g02; wu:fc44b09
Summary: Predicted to enable Wnt receptor activity and Wnt-protein binding activity. Acts upstream of or within convergent extension involved in gastrulation; epiboly; and neuromast development. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including mesoderm; nervous system; neural keel; neural tube; and trunk mesenchyme. Orthologous to human FZD7 (frizzled class receptor 7). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 6

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	6	NC_007117.7 (9703721..9707599, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	6	NC_007117.6 (9468182..9472060, complement)

Chromosome 6 - NC_007117.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

fzd7b is expressed in the neural crest and the mesodermal core of the pharyngeal arches and in the chondrocytes of newly stacked craniofacial cartilage elements.
Title: Expression of five frizzleds during zebrafish craniofacial development.
We propose that Wnt11, by interacting with Frizzled 7 and Flamingo, modulates local cell contact persistence to coordinate cell movements during gastrulation.
Title: Wnt11 controls cell contact persistence by local accumulation of Frizzled 7 at the plasma membrane.
frizzled7b is expressed in prechordal mesoderm, brain and paraxial mesoderm
Title: Zebrafish frizzled7b is expressed in prechordal mesoderm, brain and paraxial mesoderm.

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General gene information

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Markers

fe13c08.y1 (e-PCR)
- UniSTS:196140

fb38g02.x1 (e-PCR)
- UniSTS:203177

fc44b09 (e-PCR)
- UniSTS:189159

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables Wnt receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables Wnt-protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within convergent extension involved in gastrulation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within epiboly	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within neuromast development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in non-canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: frizzled-7b

Names: frizzled homolog 13; frizzled homolog 7a; frizzled homolog 7b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_170763.2 → NP_739569.1 frizzled-7b precursor

See identical proteins and their annotated locations for NP_739569.1

Status: VALIDATED

Source sequence(s)

BX927225

UniProtKB/TrEMBL

Q78AY3, Q8QFM3

Related

ENSDARP00000038430.5, ENSDART00000039280.6

Conserved Domains (2) summary

cd07458
Location:43 → 161

CRD_FZ1_like; Cysteine-rich Wnt-binding domain (CRD) of receptors similar to frizzled 1

pfam01534
Location:228 → 545

Frizzled; Frizzled/Smoothened family membrane region