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Mblac1 metallo-beta-lactamase domain containing 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 304346, updated on 2-Nov-2024

Summary

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Official Symbol
Mblac1provided by RGD
Official Full Name
metallo-beta-lactamase domain containing 1provided by RGD
Primary source
RGD:1306932
See related
EnsemblRapid:ENSRNOG00000082402 AllianceGenome:RGD:1306932
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1306932
Summary
Predicted to enable RNA endonuclease activity and metal ion binding activity. Predicted to be involved in histone mRNA metabolic process; mRNA 3'-end processing; and positive regulation of G1/S transition of mitotic cell cycle. Predicted to be located in cytoplasm and nucleus. Orthologous to human MBLAC1 (metallo-beta-lactamase domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See Mblac1 in Genome Data Viewer
Location:
12q11
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (22185142..22186404)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (17071465..17072736)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (19335841..19337103)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene adaptor related protein complex 4 subunit mu 1 Neighboring gene TATA-box binding protein associated factor 6 Neighboring gene canopy FGF signaling regulator 4 Neighboring gene neurexophilin and PC-esterase domain family, member 5 Neighboring gene neurexophilin and PC-esterase domain family, member 5 like 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA endonuclease activity ISO
Inferred from Sequence Orthology
more info
  
enables RNA endonuclease activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables metal ion binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in histone mRNA metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in histone mRNA metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mRNA 3'-end processing ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of G1/S transition of mitotic cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
metallo-beta-lactamase domain-containing protein 1
Names
endoribonuclease MBLAC1
NP_001020167.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024996.1 → NP_001020167.1  metallo-beta-lactamase domain-containing protein 1

    See identical proteins and their annotated locations for NP_001020167.1

    Status: PROVISIONAL

    Source sequence(s)
    BC079097
    UniProtKB/Swiss-Prot
    Q6AYD1
    UniProtKB/TrEMBL
    A6KST6
    Related
    ENSRNOP00000106336.1, ENSRNOT00000129882.1
    Conserved Domains (2) summary
    COG0491
    Location:81 → 244
    GloB; Glyoxylase or a related metal-dependent hydrolase, beta-lactamase superfamily II [General function prediction only]
    cd07711
    Location:24 → 240
    MBLAC1-like_MBL-fold; uncharacterized human metallo-beta-lactamase domain-containing protein 1 and related proteins; MBL-fold metallo hydrolase domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    22185142..22186404
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6AYD1.1 GenPept UniProtKB/Swiss-Prot:Q6AYD1

Gene LinkOut

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