tmod4 tropomodulin 4 (muscle) [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: tmod4provided by ZNC
Official Full Name: tropomodulin 4 (muscle)provided by ZNC
Primary source: ZFIN:ZDB-GENE-991019-9
See related: Ensembl:ENSDARG00000020890 AllianceGenome:ZFIN:ZDB-GENE-991019-9
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: sktmod; Sk-Tmod; fa12b03; wu:fa12b03
Summary: Predicted to enable tropomyosin binding activity. Acts upstream of or within skeletal myofibril assembly. Predicted to be active in striated muscle thin filament. Is expressed in head muscle and myotome. Orthologous to human TMOD4 (tropomodulin 4). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 16

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	16	NC_007127.7 (29650738..29684193)
105	previous assembly	GRCz10 (GCF_000002035.5)	16	NC_007127.6 (29716115..29749570)

Chromosome 16 - NC_007127.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TMOD4 is a novel candidate for unresolved nemaline myopathies; the tmod4(trg) mutant may be a valuable tool to study human muscle disorders
Title: Loss of Tropomodulin4 in the zebrafish mutant träge causes cytoplasmic rod formation and muscle weakness reminiscent of nemaline myopathy.

Submit: New GeneRIF Correction

General gene information

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Markers

fc01a04.x1 (e-PCR)
- UniSTS:187682

fa12b03.s1 (e-PCR)
- UniSTS:188807

aa494753 (e-PCR)
- UniSTS:186809

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables tropomyosin binding	IBA Inferred from Biological aspect of Ancestor more info
enables tropomyosin binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in muscle contraction	IBA Inferred from Biological aspect of Ancestor more info
involved_in myofibril assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within pointed-end actin filament capping	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within skeletal myofibril assembly	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
is_active_in myofibril	IBA Inferred from Biological aspect of Ancestor more info
is_active_in striated muscle thin filament	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: tropomodulin-4

Names: skeletal tropomodulin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131196.2 → NP_571271.1 tropomodulin-4

See identical proteins and their annotated locations for NP_571271.1

Status: VALIDATED

Source sequence(s)

CT954330, EB768043, EH434020, EH602087

UniProtKB/TrEMBL

A0A2R8QJ05, F6P9H6, Q9PUQ6

Related

ENSDARP00000112954.1, ENSDART00000137153.2

Conserved Domains (2) summary

cd00116
Location:235 → 314

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

pfam03250
Location:4 → 140

Tropomodulin; Tropomodulin