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gata2a GATA binding protein 2a [ Danio rerio (zebrafish) ]

Gene ID: 30480, updated on 2-Nov-2024

Summary

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Official Symbol
gata2aprovided by ZNC
Official Full Name
GATA binding protein 2aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-980526-260
See related
Ensembl:ENSDARG00000059327 AllianceGenome:ZFIN:ZDB-GENE-980526-260
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zg2; gata2
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within circulatory system development; hemopoiesis; and ventral spinal cord interneuron differentiation. Predicted to be active in nucleus. Is expressed in several structures, including hematopoietic system; mesoderm; nervous system; presumptive structure; and trunk vasculature. Human ortholog(s) of this gene implicated in acute myeloid leukemia; depressive disorder; immunodeficiency 21; myelodysplastic syndrome; and myeloid leukemia. Orthologous to human GATA2 (GATA binding protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See gata2a in Genome Data Viewer
Location:
chromosome: 11
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (3847883..3865540, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (3828496..3846256, complement)

Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene inter-alpha-trypsin inhibitor heavy chain 3a, tandem duplicate 1 Neighboring gene inter-alpha-trypsin inhibitor heavy chain 3a, tandem duplicate 2 Neighboring gene ribophorin I Neighboring gene polybromo 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Compromised N-Glycosylation Processing of Kv3.1b Correlates with Perturbed Motor Neuron Structure and Locomotor Activity. Issa FA, et al. Biology (Basel), 2021 May 30. PMID 34070741, Free PMC Article
  2. Development of enhancer-trapping and -detection vectors mediated by the Tol2 transposon in zebrafish. Chan S, et al. PeerJ, 2019. PMID 31106068, Free PMC Article
  3. An Oct-1 binding site mediates activation of the gata2 promoter by BMP signaling. Oren T, et al. Nucleic Acids Res, 2005. PMID 16061939, Free PMC Article
  4. Large-scale enhancer detection in the zebrafish genome. Ellingsen S, et al. Development, 2005 Sep. PMID 16049110
  5. Modification of bacterial artificial chromosomes through chi-stimulated homologous recombination and its application in zebrafish transgenesis. Jessen JR, et al. Proc Natl Acad Sci U S A, 1998 Apr 28. PMID 9560239, Free PMC Article

See all (337) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Lineage skewing and genome instability underlie marrow failure in a zebrafish model of GATA2 deficiency.
    Title: Lineage skewing and genome instability underlie marrow failure in a zebrafish model of GATA2 deficiency.
  2. Essential role for Gata2 in modulating lineage output from hematopoietic stem cells in zebrafish.
    Title: Essential role for Gata2 in modulating lineage output from hematopoietic stem cells in zebrafish.
  3. Single-cell ATAC-seq reveals GATA2-dependent priming defect in myeloid and a maturation bottleneck in lymphoid lineages.
    Title: Single-cell ATAC-seq reveals GATA2-dependent priming defect in myeloid and a maturation bottleneck in lymphoid lineages.
  4. Enrichment of hematopoietic stem/progenitor cells in the zebrafish kidney.
    Title: Enrichment of hematopoietic stem/progenitor cells in the zebrafish kidney.
  5. Our results indicate that Kzp is a critical transcriptional factor for the expression of gata2 and pu.1 to modulate primitive hematopoiesis.
    Title: Kzp regulates the transcription of gata2 and pu.1 during primitive hematopoiesis in zebrafish embryos.
  6. Sox4b is expressed in zebrafish during pituitary development and plays a crucial role in the differentiation of thyrotrope and gonadotrope cells through induction of gata2a expression
    Title: The HMG-box transcription factor Sox4b is required for pituitary expression of gata2a and specification of thyrotrope and gonadotrope cells in zebrafish.
  7. gata2 down-regulation is pivotal for miR-451-driven erythroid maturation
    Title: miR-451 regulates zebrafish erythroid maturation in vivo via its target gata2.
  8. we have identified a 224 bps cis-acting element that is sufficient to drive reporter gene expression in a manner that recapitulates hematopoietic GATA-2 expression pattern in a stable transgenic zebrafish line
    Title: A highly conserved regulatory element controls hematopoietic expression of GATA-2 in zebrafish.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within atrioventricular valve formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell fate commitment IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within dorsal aorta morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within erythrocyte development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within myeloid cell development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of miRNA transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within primitive hemopoiesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
NOT acts_upstream_of_or_within regulation of myeloid cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within ventral spinal cord interneuron differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
endothelial transcription factor GATA-2a
Names
GATA-binding protein 2
gta2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131233.1 → NP_571308.1  endothelial transcription factor GATA-2a

    See identical proteins and their annotated locations for NP_571308.1

    Status: PROVISIONAL

    Source sequence(s)
    BC053131
    UniProtKB/TrEMBL
    A0A8N7UZH9, F1QT93, Q7T3G1
    Related
    ENSDARP00000076860.3, ENSDART00000082425.5
    Conserved Domains (2) summary
    smart00401
    Location:320 → 369
    ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
    cd00202
    Location:325 → 373
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007122.7 Reference GRCz11 Primary Assembly

    Range
    3847883..3865540 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009305782.4 → XP_009304057.1  endothelial transcription factor GATA-2a isoform X1

    See identical proteins and their annotated locations for XP_009304057.1

    UniProtKB/TrEMBL
    A0A2R9YJP8, A0A8M3AXB8
    Conserved Domains (2) summary
    smart00401
    Location:324 → 373
    ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
    cd00202
    Location:329 → 377
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C

  2. XM_009305781.4 → XP_009304056.1  endothelial transcription factor GATA-2a isoform X1

    See identical proteins and their annotated locations for XP_009304056.1

    UniProtKB/TrEMBL
    A0A2R9YJP8, A0A8M3AXB8
    Related
    ENSDARP00000076855.4, ENSDART00000082420.4
    Conserved Domains (2) summary
    smart00401
    Location:324 → 373
    ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
    cd00202
    Location:329 → 377
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C

  3. XM_068224106.1 → XP_068080207.1  endothelial transcription factor GATA-2a isoform X3

  4. XM_021479548.2 → XP_021335223.1  endothelial transcription factor GATA-2a isoform X2

    UniProtKB/TrEMBL
    A0A8M9Q709
    Conserved Domains (1) summary
    cd00202
    Location:266 → 314
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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