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ldhba lactate dehydrogenase Ba [ Danio rerio (zebrafish) ]

Gene ID: 30497, updated on 2-Nov-2024

Summary

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Official Symbol
ldhbaprovided by ZNC
Official Full Name
lactate dehydrogenase Baprovided by ZNC
Primary source
ZFIN:ZDB-GENE-991026-6
See related
Ensembl:ENSDARG00000019644 AllianceGenome:ZFIN:ZDB-GENE-991026-6
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
ldhb; LDH-B-A; wu:fa16d07; wu:fa20c10; wu:fa96a08
Summary
Predicted to enable L-lactate dehydrogenase activity. Predicted to be involved in lactate metabolic process and pyruvate metabolic process. Predicted to act upstream of or within carboxylic acid metabolic process. Predicted to be located in cytoplasm. Predicted to be active in mitochondrion. Is expressed in several structures, including alar plate midbrain region; musculature system; nervous system; pronephric duct; and yolk syncytial layer. Orthologous to human LDHB (lactate dehydrogenase B). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See ldhba in Genome Data Viewer
Location:
chromosome: 4
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (16829111..16835904, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (16840135..16846928, complement)

Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene spexin hormone Neighboring gene glycogen synthase 2 Neighboring gene kisspeptin 2 Neighboring gene solute carrier family 25 member 3a Neighboring gene thymopoietin a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Phylogenetic analysis of vertebrate lactate dehydrogenase (LDH) multigene families. Li YJ, et al. J Mol Evol, 2002 May. PMID 11965434
  2. Lactate metabolism coordinates macrophage response and regeneration in zebrafish. Bohaud C, et al. Theranostics, 2022. PMID 35664055, Free PMC Article
  3. Global proteomics analysis of testis and ovary in adult zebrafish (Danio rerio). Groh KJ, et al. Fish Physiol Biochem, 2011 Sep. PMID 21229308, Free PMC Article
  4. Interacting Effects of Cell Size and Temperature on Gene Expression, Growth, Development and Swimming Performance in Larval Zebrafish. van de Pol ILE, et al. Front Physiol, 2021. PMID 34950046, Free PMC Article
  5. A transgenic zebrafish liver tumor model with inducible Myc expression reveals conserved Myc signatures with mammalian liver tumors. Li Z, et al. Dis Model Mech, 2013 Mar. PMID 23038063, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables L-lactate dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables L-lactate dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within carboxylic acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lactate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in pyruvate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
L-lactate dehydrogenase B-A chain
Names
L-lactate dehydrogenase B chain
LDH-B
lactate dehydrogenase B4
NP_571322.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131247.1 → NP_571322.1  L-lactate dehydrogenase B-A chain

    See identical proteins and their annotated locations for NP_571322.1

    Status: PROVISIONAL

    Source sequence(s)
    AF067202
    UniProtKB/Swiss-Prot
    Q9PVK4
    Related
    ENSDARP00000013329.6, ENSDART00000010777.7
    Conserved Domains (2) summary
    cd05293
    Location:19 → 330
    LDH_1; A subgroup of L-lactate dehydrogenases
    PLN02602
    Location:4 → 332
    PLN02602; lactate dehydrogenase

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007115.7 Reference GRCz11 Primary Assembly

    Range
    16829111..16835904 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9PVK4.4 GenPept UniProtKB/Swiss-Prot:Q9PVK4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.