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dlx2a distal-less homeobox 2a [ Danio rerio (zebrafish) ]

Gene ID: 30574, updated on 10-Nov-2024

Summary

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Official Symbol
dlx2aprovided by ZNC
Official Full Name
distal-less homeobox 2aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-980526-212
See related
Ensembl:ENSDARG00000079964 AllianceGenome:ZFIN:ZDB-GENE-980526-212
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
dlx2; dlx-2; zgc:110518
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including neural crest cell development; pharyngeal system development; and skeletal system development. Predicted to be located in nucleus. Is expressed in several structures, including brain; cranial cartilage; neural crest; pectoral fin bud; and pharyngeal arch. Orthologous to human DLX2 (distal-less homeobox 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See dlx2a in Genome Data Viewer
Location:
chromosome: 9
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (3397407..3400729, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (3425878..3429200, complement)

Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene histone acetyltransferase 1 Neighboring gene uncharacterized LOC137496440 Neighboring gene distal-less homeobox 1a Neighboring gene integrin, alpha 6a Neighboring gene cytochrome b reductase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. The chinless mutation and neural crest cell interactions in zebrafish jaw development. Schilling TF, et al. Development, 1996 May. PMID 8625830
  2. Comparison of solvate ionic liquids and DMSO as an in vivo delivery and storage media for small molecular therapeutics. Yoganantharajah P, et al. BMC Biotechnol, 2018 May 29. PMID 29843701, Free PMC Article
  3. Functional conservation of a forebrain enhancer from the elephant shark (Callorhinchus milii ) in zebrafish and mice. MacDonald RB, et al. BMC Evol Biol, 2010 May 26. PMID 20504318, Free PMC Article
  4. Contributions of developmental studies in the dogfish Scyliorhinus canicula to the brain anatomy of elasmobranchs: insights on the basal ganglia. Quintana-Urzainqui I, et al. Brain Behav Evol, 2012. PMID 22986828
  5. Macondo crude oil from the Deepwater Horizon oil spill disrupts specific developmental processes during zebrafish embryogenesis. de Soysa TY, et al. BMC Biol, 2012 May 4. PMID 22559716, Free PMC Article

See all (402) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that dlx1a/2a and dlx5a/6a expressing progenitors give rise, for the most part, to small populations of cells which constitute only a small proportion of GABAergic cells in the adult brain tissue.
    Title: Lineage tracing of dlx1a/2a and dlx5a/6a expressing cells in the developing zebrafish brain.
  2. dlx1a/2a act downstream of ascl1a but upstream of dlx5a/dlx6a and gad1b to activate GABAergic specification
    Title: The ascl1a and dlx genes have a regulatory role in the development of GABAergic interneurons in the zebrafish diencephalon.
  3. This study demonistrated that dlex2 expresssion aroud striatal and pallidal territories.
    Title: Contributions of developmental studies in the dogfish Scyliorhinus canicula to the brain anatomy of elasmobranchs: insights on the basal ganglia.
  4. embryos injected with dlx1a and dlx2a but not dlx1a MOs exhibit reduced and dysmorphic arch cartilage elements.
    Title: Zebrafish dlx2a contributes to hindbrain neural crest survival, is necessary for differentiation of sensory ganglia and functions with dlx1a in maturation of the arch cartilage elements.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cartilage development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within cartilage development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chordate embryonic development IEA
Inferred from Electronic Annotation
more info
  
involved_in embryonic morphogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in embryonic skeletal system development IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within embryonic viscerocranium morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within embryonic viscerocranium morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of photoreceptor cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within neural crest cell development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within peripheral nervous system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within pharyngeal system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of amacrine cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within ribosome biogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
homeobox protein Dlx2a
Names
distal-less homeobox gene 2a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131311.2 → NP_571386.2  homeobox protein Dlx2a

    Status: VALIDATED

    Source sequence(s)
    CU469503, DT059718
    UniProtKB/Swiss-Prot
    P50574
    UniProtKB/TrEMBL
    A0A8N7UZI8, F6NKE2
    Related
    ENSDARP00000103004.2, ENSDART00000111386.4
    Conserved Domains (2) summary
    pfam00046
    Location:130 → 183
    Homeobox; Homeobox domain
    pfam12413
    Location:32 → 107
    DLL_N; Homeobox protein distal-less-like N terminal

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007120.7 Reference GRCz11 Primary Assembly

    Range
    3397407..3400729 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P50574.1 GenPept UniProtKB/Swiss-Prot:P50574

Gene LinkOut

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