cpeb1b cytoplasmic polyadenylation element binding protein 1b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: cpeb1bprovided by ZNC
Official Full Name: cytoplasmic polyadenylation element binding protein 1bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-990927-1
See related: Ensembl:ENSDARG00000008454 AllianceGenome:ZFIN:ZDB-GENE-990927-1
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: ZOR-1; cpeb1; zorba; cepb1b; fd15c06; wu:fd15c06
Summary: Enables RNA binding activity. Predicted to be involved in several processes, including cellular response to hypoxia; cellular response to insulin stimulus; and negative regulation of cytoplasmic translation. Predicted to act upstream of or within mRNA processing and regulation of translation. Part of protein-containing complex. Is expressed in blastomere; germ line cell; nervous system; and notochord. Orthologous to human CPEB1 (cytoplasmic polyadenylation element binding protein 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 7

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	7	NC_007118.7 (48240707..48251239, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	7	NC_007118.6 (47967931..47978556, complement)

Chromosome 7 - NC_007118.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

c-mos mRNA localizes with Zorba around the animal pole in the zebrafish oocyte suggesting that the animal cortex is the central core of oocyte maturation in zebrafish.
Title: Localization of c-mos mRNA around the animal pole in the zebrafish oocyte with Zor-1/Zorba.

Submit: New GeneRIF Correction

General gene information

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Markers

zorba (e-PCR), detects polymorphism
- UniSTS:205463

fd15c06.x1 (e-PCR)
- UniSTS:204194

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	IPI Inferred from Physical Interaction more info	PubMed
enables mRNA 3'-UTR AU-rich region binding	ISS Inferred from Sequence or Structural Similarity more info
enables mRNA 3'-UTR binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA 3'-UTR binding	IEA Inferred from Electronic Annotation more info
enables mRNA regulatory element binding translation repressor activity	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA regulatory element binding translation repressor activity	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ribosome binding	IBA Inferred from Biological aspect of Ancestor more info
enables translation factor activity, RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables translation regulator activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to amino acid stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to hypoxia	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to insulin stimulus	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cytoplasmic translation	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of cytoplasmic translation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of mRNA 3'-end processing	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of translation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
part_of protein-containing complex	IPI Inferred from Physical Interaction more info	PubMed
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info	PubMed
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: cytoplasmic polyadenylation element-binding protein 1

Names: CPE-BP1; CPE-binding protein 1; CPEB-1; Orb/CPEB-related RNA-binding protein; protein Zorba; zebrafish orb-type a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131427.2 → NP_571502.2 cytoplasmic polyadenylation element-binding protein 1

See identical proteins and their annotated locations for NP_571502.2

Status: VALIDATED

Source sequence(s)

AB011680, CR354581, EH503358

UniProtKB/Swiss-Prot

O93386, Q9YGX5

UniProtKB/TrEMBL

A2CE67

Related

ENSDARP00000089674.2, ENSDART00000098904.4

Conserved Domains (4) summary

cd12723
Location:302 → 409

RRM1_CPEB1; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins

cd12725
Location:420 → 505

RRM2_CPEB1; RNA recognition motif 2 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins

pfam16366
Location:497 → 552

CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain

pfam16368
Location:1 → 300

CEBP1_N; Cytoplasmic polyadenylation element-binding protein 1 N-terminus

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007118.7 Reference GRCz11 Primary Assembly

Range

48240707..48251239 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021477394.2 → XP_021333069.1 cytoplasmic polyadenylation element-binding protein 1 isoform X5

UniProtKB/TrEMBL

A0A8M9Q7I0

Conserved Domains (4) summary

cd12723
Location:302 → 404

RRM1_CPEB1; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins

cd12725
Location:415 → 500

RRM2_CPEB1; RNA recognition motif 2 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins

pfam16366
Location:492 → 547

CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain

pfam16368
Location:1 → 300

CEBP1_N; Cytoplasmic polyadenylation element-binding protein 1 N-terminus
XM_068222159.1 → XP_068078260.1 cytoplasmic polyadenylation element-binding protein 1 isoform X3
XM_068222158.1 → XP_068078259.1 cytoplasmic polyadenylation element-binding protein 1 isoform X2
XM_068222157.1 → XP_068078258.1 cytoplasmic polyadenylation element-binding protein 1 isoform X1
XM_068222160.1 → XP_068078261.1 cytoplasmic polyadenylation element-binding protein 1 isoform X4