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tek TEK tyrosine kinase, endothelial [ Danio rerio (zebrafish) ]

Gene ID: 30747, updated on 2-Nov-2024

Summary

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Official Symbol
tekprovided by ZNC
Official Full Name
TEK tyrosine kinase, endothelialprovided by ZNC
Primary source
ZFIN:ZDB-GENE-990415-56
See related
Ensembl:ENSDARG00000028663 AllianceGenome:ZFIN:ZDB-GENE-990415-56
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
tie2; tie-2
Summary
Predicted to enable transmembrane receptor protein tyrosine kinase activity. Acts upstream of or within angiogenesis and heart development. Predicted to be located in several cellular components, including cytoplasm; cytoskeleton; and focal adhesion. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Is expressed in endothelial cell; vasculature; and vertical myoseptum. Human ortholog(s) of this gene implicated in arteriovenous malformation; multiple cutaneous and mucosal venous malformations; and renal Wilms' tumor. Orthologous to human TEK (TEK receptor tyrosine kinase). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See tek in Genome Data Viewer
Location:
chromosome: 5
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (480080..496790)
105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (473662..497870)

Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137495540 Neighboring gene intraflagellar transport 74 Neighboring gene uncharacterized LOC101883870 Neighboring gene uncharacterized LOC110439795

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Functional assessment of two variants of unknown significance in TEK by endothelium-specific expression in zebrafish embryos. Bell LM, et al. Hum Mol Genet, 2021 Dec 17. PMID 34254124
  2. Effects of simulated microgravity on the development of the swimbladder and buoyancy control in larval zebrafish (Danio rerio). Lindsey BW, et al. J Exp Zool A Ecol Genet Physiol, 2011 Jun 1. PMID 21394929
  3. Using Ultra-Performance Liquid Chromatography Quadrupole Time of Flight Mass Spectrometry-Based Chemometrics for the Identification of Anti-angiogenic Biflavonoids from Edible Garcinia Species. Li P, et al. J Agric Food Chem, 2017 Sep 27. PMID 28926234
  4. Mirror movement-like defects in startle behavior of zebrafish dcc mutants are caused by aberrant midline guidance of identified descending hindbrain neurons. Jain RA, et al. J Neurosci, 2014 Feb 19. PMID 24553931, Free PMC Article
  5. Local cortical tension by myosin II guides 3D endothelial cell branching. Fischer RS, et al. Curr Biol, 2009 Feb 10. PMID 19185493, Free PMC Article

See all (83) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Tek (Tie2) is not required for cardiovascular development in zebrafish.
    Title: Tek (Tie2) is not required for cardiovascular development in zebrafish.
  2. observations demonstrate that Tie2 is an important regulator of tip cell behaviors
    Title: The zebrafish Tie2 signaling controls tip cell behaviors and acts synergistically with Vegf pathway in developmental angiogenesis.
  3. Tie-1 and Tie-2 are not required for early heart development, yet they have redundant roles for the maintenance of endocardial-myocardial connection in later stages.
    Title: Zebrafish Tie-2 shares a redundant role with Tie-1 in heart development and regulates vessel integrity.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane receptor protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane receptor protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within angiogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within angiogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cell surface receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in endothelial cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within heart development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of endothelial cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in focal adhesion IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
angiopoietin-1 receptor
Names
endothelium-specific receptor tyrosine kinase 2
tyrosine kinase with Ig and EGF homology domains-2
tyrosine-protein kinase receptor Tie-2
NP_571536.1
XP_009299388.1
XP_021331678.1
XP_021331680.1
XP_068077196.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131461.1 → NP_571536.1  angiopoietin-1 receptor precursor

    See identical proteins and their annotated locations for NP_571536.1

    Status: PROVISIONAL

    Source sequence(s)
    AF053632
    UniProtKB/Swiss-Prot
    O73791
    Related
    ENSDARP00000055680.5, ENSDART00000055681.7
    Conserved Domains (7) summary
    cd05088
    Location:808 → 1110
    PTKc_Tie2; Catalytic domain of the Protein Tyrosine Kinase, Tie2
    smart00060
    Location:632 → 716
    FN3; Fibronectin type 3 domain
    smart00221
    Location:816 → 1084
    STYKc; Protein kinase; unclassified specificity
    smart00410
    Location:354 → 439
    IG_like; Immunoglobulin like
    pfam00041
    Location:541 → 621
    fn3; Fibronectin type III domain
    pfam07974
    Location:224 → 255
    EGF_2; EGF-like domain
    pfam10430
    Location:25 → 121
    Ig_Tie2_1; Tie-2 Ig-like domain 1

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007116.7 Reference GRCz11 Primary Assembly

    Range
    480080..496790
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009301113.4 → XP_009299388.1  angiopoietin-1 receptor isoform X1

    UniProtKB/TrEMBL
    A0A8M3ARU2
    Conserved Domains (7) summary
    cd05088
    Location:809 → 1111
    PTKc_Tie2; Catalytic domain of the Protein Tyrosine Kinase, Tie2
    smart00060
    Location:633 → 717
    FN3; Fibronectin type 3 domain
    smart00221
    Location:817 → 1085
    STYKc; Protein kinase; unclassified specificity
    smart00410
    Location:354 → 439
    IG_like; Immunoglobulin like
    pfam00041
    Location:541 → 621
    fn3; Fibronectin type III domain
    pfam07974
    Location:224 → 255
    EGF_2; EGF-like domain
    pfam10430
    Location:25 → 121
    Ig_Tie2_1; Tie-2 Ig-like domain 1

  2. XM_068221095.1 → XP_068077196.1  angiopoietin-1 receptor isoform X2

  3. XM_021476003.2 → XP_021331678.1  angiopoietin-1 receptor isoform X3

    UniProtKB/TrEMBL
    A0A8M9PX37
    Conserved Domains (5) summary
    cd05088
    Location:689 → 991
    PTKc_Tie2; Catalytic domain of the Protein Tyrosine Kinase, Tie2
    smart00060
    Location:513 → 597
    FN3; Fibronectin type 3 domain
    smart00410
    Location:234 → 319
    IG_like; Immunoglobulin like
    pfam07974
    Location:104 → 135
    EGF_2; EGF-like domain
    pfam00041
    Location:421 → 501
    fn3; Fibronectin type III domain

  4. XM_021476005.2 → XP_021331680.1  angiopoietin-1 receptor isoform X3

    UniProtKB/TrEMBL
    A0A8M9PX37
    Conserved Domains (5) summary
    cd05088
    Location:689 → 991
    PTKc_Tie2; Catalytic domain of the Protein Tyrosine Kinase, Tie2
    smart00060
    Location:513 → 597
    FN3; Fibronectin type 3 domain
    smart00410
    Location:234 → 319
    IG_like; Immunoglobulin like
    pfam07974
    Location:104 → 135
    EGF_2; EGF-like domain
    pfam00041
    Location:421 → 501
    fn3; Fibronectin type III domain

RNA

  1. XR_002458735.2 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O73791.1 GenPept UniProtKB/Swiss-Prot:O73791

Gene LinkOut

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