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stat3 signal transducer and activator of transcription 3 (acute-phase response factor) [ Danio rerio (zebrafish) ]

Gene ID: 30767, updated on 14-Nov-2024

Summary

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Official Symbol
stat3provided by ZNC
Official Full Name
signal transducer and activator of transcription 3 (acute-phase response factor)provided by ZNC
Primary source
ZFIN:ZDB-GENE-980526-68
See related
Ensembl:ENSDARG00000022712 AllianceGenome:ZFIN:ZDB-GENE-980526-68
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
STAT3b1; STAT3b2; z-Stat3; wu:fc15d02; wu:fl59g06
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including cardiac muscle tissue regeneration; embryonic morphogenesis; and neuron development. Predicted to be part of RNA polymerase II transcription regulator complex. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including blastomere; bone tissue; epidermal superficial stratum; head; and nervous system. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); hyper IgE recurrent infection syndrome 1; reproductive organ cancer (multiple); and type 2 diabetes mellitus. Orthologous to human STAT3 (signal transducer and activator of transcription 3). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See stat3 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (17030665..17108657)
105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (16880851..16960144)

Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene ATPase H+ transporting V0 subunit a1a Neighboring gene caveolae associated protein 1a Neighboring gene signal transducer and activator of transcription 5a Neighboring gene hypocretin (orexin) neuropeptide precursor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Identification of two Stat3 variants lacking a transactivation domain in grass carp: New insights into alternative splicing in the modification of teleost Stat3 signaling. Wang X, et al. Fish Shellfish Immunol, 2018 Jun. PMID 29555584
  2. Identification and functional evaluation of two STAT3 variants in grass carp: Implication for the existence of specific alternative splicing of STAT3 gene in teleost. Du L, et al. Dev Comp Immunol, 2017 Nov. PMID 28698048
  3. Stat3 Has a Different Role in Axon Growth During Development Than It Does in Axon Regeneration After Injury. Duan Q, et al. Mol Neurobiol, 2024 Mar. PMID 37775721
  4. A new transgenic line reporting pStat3 signaling in glia. Zhao XF, et al. Zebrafish, 2014 Dec. PMID 25372358, Free PMC Article
  5. STAT3 noncell-autonomously controls planar cell polarity during zebrafish convergence and extension. Miyagi C, et al. J Cell Biol, 2004 Sep 27. PMID 15452141, Free PMC Article

See all (130) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Stat3 Regulates Developmental Hematopoiesis and Impacts Myeloid Cell Function via Canonical and Non-Canonical Modalities.
    Title: Stat3 Regulates Developmental Hematopoiesis and Impacts Myeloid Cell Function via Canonical and Non-Canonical Modalities.
  2. Stat3 Has a Different Role in Axon Growth During Development Than It Does in Axon Regeneration After Injury.
    Title: Stat3 Has a Different Role in Axon Growth During Development Than It Does in Axon Regeneration After Injury.
  3. Contribution of Signal Transducer and Activator of Transcription 3 (STAT3) to Bone Development and Repair.
    Title: Contribution of Signal Transducer and Activator of Transcription 3 (STAT3) to Bone Development and Repair.
  4. Y705 and S727 are required for the mitochondrial import and transcriptional activities of STAT3, and for regulation of stem cell proliferation.
    Title: Y705 and S727 are required for the mitochondrial import and transcriptional activities of STAT3, and for regulation of stem cell proliferation.
  5. The stem-like Stat3-responsive cells of zebrafish intestine are Wnt/beta-catenin dependent.
    Title: The stem-like Stat3-responsive cells of zebrafish intestine are Wnt/β-catenin dependent.
  6. Stat3 is required for hepatocyte cell differentiation and liver regeneration.
    Title: Stat3 Regulates Liver Progenitor Cell-Driven Liver Regeneration in Zebrafish.
  7. Stat3 regulates cell proliferation and axis extension in part via upregulation of Cdc25a expression during oogenesis. Accordingly, restoring Cdc25a expression in stat3 mutants partially suppressed cell proliferation and gastrulation defects.
    Title: Stat3/Cdc25a-dependent cell proliferation promotes embryonic axis extension during zebrafish gastrulation.
  8. PTPN9 plays an important role in erythropoiesis by disrupting an inhibitory complex of phosphorylated STAT3, GATA1 and ZBP-89.
    Title: Protein tyrosine phosphatase PTPN9 regulates erythroid cell development through STAT3 dephosphorylation in zebrafish.
  9. Stat3-Efemp2a modulates the fibrillar matrix for cohesive movement of prechordal plate progenitors.
    Title: Stat3-Efemp2a modulates the fibrillar matrix for cohesive movement of prechordal plate progenitors.
  10. Transgenic Stat3 inhibition in cardiomyocytes restricted injury-induced proliferation and regeneration, but did not reduce cardiogenesis during animal growth.
    Title: Translational profiling of cardiomyocytes identifies an early Jak1/Stat3 injury response required for zebrafish heart regeneration.
Submit: New GeneRIF Correction See all GeneRIFs (14)

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC193054

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within axis elongation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cardiac muscle tissue regeneration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cell migration involved in gastrulation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cell surface receptor signaling pathway via JAK-STAT IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within epithelial to mesenchymal transition IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within establishment of cell polarity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within establishment of planar polarity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within germ cell development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within hepatocyte differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within inner ear receptor cell development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within motor neuron axon guidance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within notochord morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of glial cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within posterior lateral line neuromast hair cell development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regeneration IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of bone development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of cell shape IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of cell size IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within retina morphogenesis in camera-type eye IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within skeletal system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
signal transducer and activator of transcription 3
Names
signal transduction and activation of transcription 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131479.1 → NP_571554.1  signal transducer and activator of transcription 3

    See identical proteins and their annotated locations for NP_571554.1

    Status: PROVISIONAL

    Source sequence(s)
    AJ005693
    UniProtKB/TrEMBL
    A0A8N7V0P2, O93599
    Related
    ENSDARP00000095292.4, ENSDART00000104519.6
    Conserved Domains (4) summary
    cd10374
    Location:555 → 718
    SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
    smart00964
    Location:2 → 119
    STAT_int; STAT protein, protein interaction domain
    pfam01017
    Location:140 → 320
    STAT_alpha; STAT protein, all-alpha domain
    pfam02864
    Location:322 → 574
    STAT_bind; STAT protein, DNA binding domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007114.7 Reference GRCz11 Primary Assembly

    Range
    17030665..17108657
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005163796.4 → XP_005163853.1  signal transducer and activator of transcription 3 isoform X4

    See identical proteins and their annotated locations for XP_005163853.1

    UniProtKB/TrEMBL
    A0A8M2BAW6, Q6NV46
    Related
    ENSDARP00000075300.5, ENSDART00000080854.7
    Conserved Domains (4) summary
    cd10374
    Location:555 → 718
    SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
    smart00964
    Location:2 → 119
    STAT_int; STAT protein, protein interaction domain
    pfam01017
    Location:140 → 320
    STAT_alpha; STAT protein, all-alpha domain
    pfam02864
    Location:322 → 574
    STAT_bind; STAT protein, DNA binding domain

  2. XM_021469347.2 → XP_021325022.1  signal transducer and activator of transcription 3 isoform X5

    UniProtKB/TrEMBL
    A0A0R4IGF2, A0A1S6L752
    Related
    ENSDARP00000134796.2, ENSDART00000159849.2
    Conserved Domains (4) summary
    cd10374
    Location:555 → 718
    SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
    smart00964
    Location:2 → 119
    STAT_int; STAT protein, protein interaction domain
    pfam01017
    Location:140 → 320
    STAT_alpha; STAT protein, all-alpha domain
    pfam02864
    Location:322 → 574
    STAT_bind; STAT protein, DNA binding domain

  3. XM_005163795.5 → XP_005163852.2  signal transducer and activator of transcription 3 isoform X3

    UniProtKB/TrEMBL
    A0A8M2BBA1
    Conserved Domains (4) summary
    cd10374
    Location:570 → 733
    SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
    smart00964
    Location:17 → 134
    STAT_int; STAT protein, protein interaction domain
    pfam01017
    Location:155 → 335
    STAT_alpha; STAT protein, all-alpha domain
    pfam02864
    Location:337 → 589
    STAT_bind; STAT protein, DNA binding domain

  4. XM_005163793.5 → XP_005163850.2  signal transducer and activator of transcription 3 isoform X1

    UniProtKB/TrEMBL
    A0A8M2BB24
    Conserved Domains (4) summary
    cd10374
    Location:570 → 733
    SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
    smart00964
    Location:17 → 134
    STAT_int; STAT protein, protein interaction domain
    pfam01017
    Location:155 → 335
    STAT_alpha; STAT protein, all-alpha domain
    pfam02864
    Location:337 → 589
    STAT_bind; STAT protein, DNA binding domain

  5. XM_005163794.5 → XP_005163851.2  signal transducer and activator of transcription 3 isoform X2

    UniProtKB/TrEMBL
    A0A8M2BAX1
    Conserved Domains (4) summary
    cd10374
    Location:570 → 733
    SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
    smart00964
    Location:17 → 134
    STAT_int; STAT protein, protein interaction domain
    pfam01017
    Location:155 → 335
    STAT_alpha; STAT protein, all-alpha domain
    pfam02864
    Location:337 → 589
    STAT_bind; STAT protein, DNA binding domain
Nucleotide Protein Strain
Heading Accession and Version

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