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Gpr19 G protein-coupled receptor 19 [ Rattus norvegicus (Norway rat) ]

Gene ID: 312787, updated on 10-Jul-2024

Summary

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Official Symbol
Gpr19provided by RGD
Official Full Name
G protein-coupled receptor 19provided by RGD
Primary source
RGD:71045
See related
EnsemblRapid:ENSRNOG00000007126 AllianceGenome:RGD:71045
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in cilium. Predicted to be active in plasma membrane. Orthologous to human GPR19 (G protein-coupled receptor 19). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 18.3), Brain (RPKM 15.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Gpr19 in Genome Data Viewer
Location:
4q43
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (169442278..169468805, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (167710944..167739232, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (168639930..168668345, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene dual specificity phosphatase 16 Neighboring gene cAMP responsive element binding protein-like 2 Neighboring gene uncharacterized LOC108350781 Neighboring gene cyclin-dependent kinase inhibitor 1B Neighboring gene proteasome maturation protein pseudogene Neighboring gene apolipoprotein L domain containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A novel gene codes for a putative G protein-coupled receptor with an abundant expression in brain. O'Dowd BF, et al. FEBS Lett, 1996 Oct 7. PMID 8830667
  2. Tubby family proteins are adapters for ciliary trafficking of integral membrane proteins. Badgandi HB, et al. J Cell Biol, 2017 Mar 6. PMID 28154160, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cilium IEA
Inferred from Electronic Annotation
more info
  
located_in cilium ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
probable G-protein coupled receptor 19

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_080579.2 → NP_542146.1  probable G-protein coupled receptor 19

    See identical proteins and their annotated locations for NP_542146.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/Swiss-Prot
    P70585, Q5FVI1
    UniProtKB/TrEMBL
    A6IME4, A6IME5
    Related
    ENSRNOP00000085068.1, ENSRNOT00000116148.2
    Conserved Domains (2) summary
    pfam00001
    Location:82 → 330
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:72 → 258
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    169442278..169468805 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039107696.2 → XP_038963624.1  probable G-protein coupled receptor 19 isoform X1

    Related
    ENSRNOP00000009341.5, ENSRNOT00000009341.7
    Conserved Domains (1) summary
    cd15008
    Location:214 → 488
    7tmA_GPR19; G protein-coupled receptor 19, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. XM_006237522.5 → XP_006237584.1  probable G-protein coupled receptor 19 isoform X2

    UniProtKB/TrEMBL
    A0A8I6GFK1, A6IME5
    Related
    ENSRNOP00000093658.2, ENSRNOT00000095765.2
    Conserved Domains (2) summary
    pfam00001
    Location:105 → 353
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:95 → 281
    7tm_4; Olfactory receptor

  3. XM_006237524.4 → XP_006237586.1  probable G-protein coupled receptor 19 isoform X3

    See identical proteins and their annotated locations for XP_006237586.1

    UniProtKB/Swiss-Prot
    P70585, Q5FVI1
    UniProtKB/TrEMBL
    A6IME4, A6IME5
    Conserved Domains (2) summary
    pfam00001
    Location:82 → 330
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:72 → 258
    7tm_4; Olfactory receptor
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P70585.2 GenPept UniProtKB/Swiss-Prot:P70585

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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