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Wiz WIZ zinc finger [ Rattus norvegicus (Norway rat) ]

Gene ID: 314598, updated on 10-Jul-2024

Summary

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Official Symbol
Wizprovided by RGD
Official Full Name
WIZ zinc fingerprovided by RGD
Primary source
RGD:1307771
See related
EnsemblRapid:ENSRNOG00000006217 AllianceGenome:RGD:1307771
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable several functions, including SET domain binding activity; histone methyltransferase binding activity; and transcription corepressor binding activity. Predicted to be involved in positive regulation of nuclear cell cycle DNA replication; protein stabilization; and regulation of transcription by RNA polymerase II. Predicted to be located in midbody and nucleoplasm. Predicted to be active in nucleus. Orthologous to human WIZ (WIZ zinc finger). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 29.0), Adrenal (RPKM 26.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Wiz in Genome Data Viewer
Location:
7q11
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (12017374..12045812, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (11366837..11395279, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (14374358..14402647, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene A-kinase anchoring protein 8 like Neighboring gene uncharacterized LOC134479821 Neighboring gene RAS protein activator like 3 Neighboring gene uncharacterized LOC134479820 Neighboring gene peptidoglycan recognition protein 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A proteomic characterization of factors enriched at nascent DNA molecules. Lopez-Contreras AJ, et al. Cell Rep, 2013 Apr 25. PMID 23545495, Free PMC Article
  2. Aberrantly Methylated-Differentially Expressed Genes Identify Novel Atherosclerosis Risk Subtypes. Xue Y, et al. Front Genet, 2020. PMID 33381146, Free PMC Article
  3. Zinc finger protein Wiz links G9a/GLP histone methyltransferases to the co-repressor molecule CtBP. Ueda J, et al. J Biol Chem, 2006 Jul 21. PMID 16702210
  4. Analysis of oxygen/glucose-deprivation-induced changes in SUMO3 conjugation using SILAC-based quantitative proteomics. Yang W, et al. J Proteome Res, 2012 Feb 3. PMID 22082260, Free PMC Article
  5. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables SET domain binding ISO
Inferred from Sequence Orthology
more info
  
enables histone methyltransferase binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription corepressor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in positive regulation of nuclear cell cycle DNA replication ISO
Inferred from Sequence Orthology
more info
  
involved_in protein stabilization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in midbody ISO
Inferred from Sequence Orthology
more info
  
NOT located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein Wiz
Names
widely-interspaced zinc finger motifs

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001427399.1 → NP_001414328.1  protein Wiz

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    Related
    ENSRNOP00000080016.2, ENSRNOT00000103303.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    12017374..12045812 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039080037.2 → XP_038935965.1  protein Wiz isoform X7

    Conserved Domains (3) summary
    PHA03247
    Location:852 → 1221
    PHA03247; large tegument protein UL36; Provisional
    PHA03321
    Location:941 → 1083
    PHA03321; tegument protein VP11/12; Provisional
    sd00017
    Location:316 → 336
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. XM_039080036.2 → XP_038935964.1  protein Wiz isoform X6

    Conserved Domains (2) summary
    PHA03247
    Location:859 → 1389
    PHA03247; large tegument protein UL36; Provisional
    sd00017
    Location:316 → 336
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. XM_039080033.2 → XP_038935961.1  protein Wiz isoform X3

    Related
    ENSRNOP00000106516.1, ENSRNOT00000134108.1
    Conserved Domains (2) summary
    PHA03321
    Location:1239 → 1381
    PHA03321; tegument protein VP11/12; Provisional
    sd00017
    Location:316 → 336
    ZF_C2H2; C2H2 Zn finger [structural motif]

  4. XM_039080035.2 → XP_038935963.1  protein Wiz isoform X5

    Related
    ENSRNOP00000107859.1, ENSRNOT00000132626.1
    Conserved Domains (3) summary
    PHA03247
    Location:1026 → 1446
    PHA03247; large tegument protein UL36; Provisional
    PHA03321
    Location:1166 → 1308
    PHA03321; tegument protein VP11/12; Provisional
    sd00017
    Location:316 → 336
    ZF_C2H2; C2H2 Zn finger [structural motif]

  5. XM_063263401.1 → XP_063119471.1  protein Wiz isoform X2

  6. XM_008765163.4 → XP_008763385.1  protein Wiz isoform X1

    See identical proteins and their annotated locations for XP_008763385.1

    Conserved Domains (2) summary
    PHA03321
    Location:1296 → 1438
    PHA03321; tegument protein VP11/12; Provisional
    sd00017
    Location:316 → 336
    ZF_C2H2; C2H2 Zn finger [structural motif]

  7. XM_017594800.3 → XP_017450289.1  protein Wiz isoform X1

    Conserved Domains (2) summary
    PHA03321
    Location:1296 → 1438
    PHA03321; tegument protein VP11/12; Provisional
    sd00017
    Location:316 → 336
    ZF_C2H2; C2H2 Zn finger [structural motif]

  8. XM_039080029.2 → XP_038935957.1  protein Wiz isoform X1

    Conserved Domains (2) summary
    PHA03321
    Location:1296 → 1438
    PHA03321; tegument protein VP11/12; Provisional
    sd00017
    Location:316 → 336
    ZF_C2H2; C2H2 Zn finger [structural motif]

  9. XM_039080038.2 → XP_038935966.1  protein Wiz isoform X8

    Conserved Domains (1) summary
    PHA03321
    Location:570 → 712
    PHA03321; tegument protein VP11/12; Provisional

  10. XM_039080040.2 → XP_038935968.1  protein Wiz isoform X10

    Conserved Domains (1) summary
    PHA03321
    Location:513 → 655
    PHA03321; tegument protein VP11/12; Provisional

  11. XM_063263404.1 → XP_063119474.1  protein Wiz isoform X13

  12. XM_039080044.2 → XP_038935972.1  protein Wiz isoform X18

    Conserved Domains (1) summary
    PHA03321
    Location:215 → 357
    PHA03321; tegument protein VP11/12; Provisional

  13. XM_039080042.2 → XP_038935970.1  protein Wiz isoform X15

    UniProtKB/TrEMBL
    A6K947, D3ZQQ2
    Related
    ENSRNOP00000008303.4, ENSRNOT00000008303.7
    Conserved Domains (2) summary
    PHA03247
    Location:133 → 663
    PHA03247; large tegument protein UL36; Provisional
    PHA03321
    Location:383 → 525
    PHA03321; tegument protein VP11/12; Provisional

  14. XM_063263406.1 → XP_063119476.1  protein Wiz isoform X15

    UniProtKB/TrEMBL
    A6K947, D3ZQQ2

  15. XM_039080031.2 → XP_038935959.1  protein Wiz isoform X1

    Conserved Domains (2) summary
    PHA03321
    Location:1296 → 1438
    PHA03321; tegument protein VP11/12; Provisional
    sd00017
    Location:316 → 336
    ZF_C2H2; C2H2 Zn finger [structural motif]

  16. XM_017594801.3 → XP_017450290.1  protein Wiz isoform X1

    Conserved Domains (2) summary
    PHA03321
    Location:1296 → 1438
    PHA03321; tegument protein VP11/12; Provisional
    sd00017
    Location:316 → 336
    ZF_C2H2; C2H2 Zn finger [structural motif]

  17. XM_039080032.2 → XP_038935960.1  protein Wiz isoform X2

    Conserved Domains (3) summary
    PHA03247
    Location:963 → 1524
    PHA03247; large tegument protein UL36; Provisional
    PHA03321
    Location:1244 → 1386
    PHA03321; tegument protein VP11/12; Provisional
    sd00017
    Location:264 → 284
    ZF_C2H2; C2H2 Zn finger [structural motif]

  18. XM_008765161.4 → XP_008763383.1  protein Wiz isoform X1

    See identical proteins and their annotated locations for XP_008763383.1

    Conserved Domains (2) summary
    PHA03321
    Location:1296 → 1438
    PHA03321; tegument protein VP11/12; Provisional
    sd00017
    Location:316 → 336
    ZF_C2H2; C2H2 Zn finger [structural motif]

  19. XM_063263403.1 → XP_063119473.1  protein Wiz isoform X12

  20. XM_063263402.1 → XP_063119472.1  protein Wiz isoform X9

  21. XM_063263407.1 → XP_063119477.1  protein Wiz isoform X17

  22. XM_063263405.1 → XP_063119475.1  protein Wiz isoform X14

  23. XM_017594803.3 → XP_017450292.1  protein Wiz isoform X4

    Conserved Domains (3) summary
    PHA03247
    Location:887 → 1448
    PHA03247; large tegument protein UL36; Provisional
    PHA03321
    Location:1168 → 1310
    PHA03321; tegument protein VP11/12; Provisional
    sd00017
    Location:188 → 208
    ZF_C2H2; C2H2 Zn finger [structural motif]

  24. XM_039080034.1 → XP_038935962.1  protein Wiz isoform X4

    Conserved Domains (3) summary
    PHA03247
    Location:887 → 1448
    PHA03247; large tegument protein UL36; Provisional
    PHA03321
    Location:1168 → 1310
    PHA03321; tegument protein VP11/12; Provisional
    sd00017
    Location:188 → 208
    ZF_C2H2; C2H2 Zn finger [structural motif]

  25. XM_039080043.2 → XP_038935971.1  protein Wiz isoform X16

    Conserved Domains (1) summary
    PHA03321
    Location:347 → 489
    PHA03321; tegument protein VP11/12; Provisional

  26. XM_039080041.2 → XP_038935969.1  protein Wiz isoform X11

    UniProtKB/TrEMBL
    A0A8I6AH19
    Related
    ENSRNOP00000093209.1, ENSRNOT00000109179.2
    Conserved Domains (1) summary
    PHA03321
    Location:477 → 619
    PHA03321; tegument protein VP11/12; Provisional

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001108064.1: Suppressed sequence

    Description
    NM_001108064.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from human: WIZ (GeneID:58525).
Nucleotide Protein Strain
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