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Mapk8ip2 mitogen-activated protein kinase 8 interacting protein 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 315220, updated on 17-Aug-2024

Summary

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Official Symbol
Mapk8ip2provided by RGD
Official Full Name
mitogen-activated protein kinase 8 interacting protein 2provided by RGD
Primary source
RGD:1309727
See related
EnsemblRapid:ENSRNOG00000032828 AllianceGenome:RGD:1309727
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
IB-2; JIP-2
Summary
Predicted to enable several functions, including MAP-kinase scaffold activity; kinesin binding activity; and protein kinase activator activity. Involved in positive regulation of stress-activated MAPK cascade. Part of protein-containing complex. Orthologous to human MAPK8IP2 (mitogen-activated protein kinase 8 interacting protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 117.8), Adrenal (RPKM 16.9) and 1 other tissue See more
Orthologs
human mouse all
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Genomic context

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See Mapk8ip2 in Genome Data Viewer
Location:
7q34
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (122406350..122416602)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (120526732..120536982)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (130430588..130440838)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene carnitine palmitoyltransferase 1B Neighboring gene uncharacterized LOC134479955 Neighboring gene choline kinase beta Neighboring gene uncharacterized LOC134479956 Neighboring gene uncharacterized LOC120093826 Neighboring gene arylsulfatase A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Behavioral and cerebellar transmission deficits in mice lacking the autism-linked gene islet brain-2. Giza J, et al. J Neurosci, 2010 Nov 3. PMID 21048139, Free PMC Article
  2. Regulatory mechanisms of mitogen-activated kinase signaling. Zhang Y, et al. Cell Mol Life Sci, 2007 Nov. PMID 17726577, Free PMC Article
  3. Interaction of Rac exchange factors Tiam1 and Ras-GRF1 with a scaffold for the p38 mitogen-activated protein kinase cascade. Buchsbaum RJ, et al. Mol Cell Biol, 2002 Jun. PMID 12024021, Free PMC Article
  4. cDNA cloning and mapping of a novel islet-brain/JNK-interacting protein. Negri S, et al. Genomics, 2000 Mar 15. PMID 10756100
  5. Fibroblast growth factor homologous factors and the islet brain-2 scaffold protein regulate activation of a stress-activated protein kinase. Schoorlemmer J, et al. J Biol Chem, 2002 Dec 20. PMID 12244047, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables JUN kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables MAP-kinase scaffold activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables MAP-kinase scaffold activity ISO
Inferred from Sequence Orthology
more info
  
enables kinesin binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activator activity ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in JNK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within JNK cascade ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within MAPK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in behavioral fear response ISO
Inferred from Sequence Orthology
more info
  
involved_in dendrite morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in excitatory postsynaptic potential ISO
Inferred from Sequence Orthology
more info
  
involved_in mating behavior ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in nonassociative learning ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of stress-activated MAPK cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of synaptic transmission, glutamatergic ISO
Inferred from Sequence Orthology
more info
  
involved_in social behavior ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  
located_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
C-Jun-amino-terminal kinase-interacting protein 2
Names
JNK MAP kinase scaffold protein 2
JNK-interacting protein 2
islet-brain-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100720.3 → NP_001094190.1  C-Jun-amino-terminal kinase-interacting protein 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/Swiss-Prot
    G3V9M2, Q3B8P9
    Related
    ENSRNOP00000052648.1, ENSRNOT00000055792.4
    Conserved Domains (2) summary
    cd11942
    Location:619 → 673
    SH3_JIP2; Src homology 3 domain of JNK-interacting protein 2
    cd01212
    Location:690 → 835
    PTB_JIP; JNK-interacting protein-like (JIP) Phosphotyrosine-binding (PTB) domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    122406350..122416602
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
G3V9M2.1 GenPept UniProtKB/Swiss-Prot:G3V9M2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Chemical Information
Molecular Biology Databases
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