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Gpr108 G protein-coupled receptor 108 [ Rattus norvegicus (Norway rat) ]

Gene ID: 316136, updated on 10-Jul-2024

Summary

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Official Symbol
Gpr108provided by RGD
Official Full Name
G protein-coupled receptor 108provided by RGD
Primary source
RGD:735149
See related
EnsemblRapid:ENSRNOG00000046128 AllianceGenome:RGD:735149
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in negative regulation of toll-like receptor signaling pathway. Predicted to be located in cis-Golgi network membrane and trans-Golgi network. Predicted to be active in Golgi apparatus and membrane. Orthologous to human GPR108 (G protein-coupled receptor 108). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 116.5), Lung (RPKM 107.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Gpr108 in Genome Data Viewer
Location:
9q11
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (2207716..2218738, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (2120740..2131771, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (9704300..9714767)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like Neighboring gene complement C3 Neighboring gene thyroid hormone receptor interactor 10 Neighboring gene SH2 domain containing 3A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in negative regulation of toll-like receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of toll-like receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of toll-like receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of immune response ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi apparatus ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in cis-Golgi network membrane IEA
Inferred from Electronic Annotation
more info
  
located_in cis-Golgi network membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cis-Golgi network membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in trans-Golgi network IEA
Inferred from Electronic Annotation
more info
  
located_in trans-Golgi network ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein GPR108

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199399.1 → NP_955431.1  protein GPR108 precursor

    See identical proteins and their annotated locations for NP_955431.1

    Status: PROVISIONAL

    Source sequence(s)
    BC061996
    UniProtKB/Swiss-Prot
    M0R518, Q6P6V6
    Related
    ENSRNOP00000097991.2, ENSRNOT00000111815.2
    Conserved Domains (1) summary
    pfam06814
    Location:248 → 536
    Lung_7-TM_R; Lung seven transmembrane receptor

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    2207716..2218738 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006244285.5 → XP_006244347.1  protein GPR108 isoform X1

    UniProtKB/Swiss-Prot
    M0R518, Q6P6V6
    Conserved Domains (1) summary
    pfam06814
    Location:248 → 547
    Lung_7-TM_R; Lung seven transmembrane receptor

  2. XM_039083463.2 → XP_038939391.1  protein GPR108 isoform X3

    UniProtKB/TrEMBL
    A0A8I6AEE0, A0A8L2QWL5
    Related
    ENSRNOP00000064473.2, ENSRNOT00000075403.3
    Conserved Domains (1) summary
    pfam06814
    Location:230 → 517
    Lung_7-TM_R; Lung seven transmembrane receptor

  3. XM_006244286.4 → XP_006244348.1  protein GPR108 isoform X2

    UniProtKB/TrEMBL
    A0A8I6AEE0
    Conserved Domains (1) summary
    pfam06814
    Location:229 → 528
    Lung_7-TM_R; Lung seven transmembrane receptor

  4. XM_063267065.1 → XP_063123135.1  protein GPR108 isoform X5

    UniProtKB/TrEMBL
    A6KQR1

  5. XM_063267064.1 → XP_063123134.1  protein GPR108 isoform X5

    UniProtKB/TrEMBL
    A6KQR1

  6. XM_063267063.1 → XP_063123133.1  protein GPR108 isoform X4

    UniProtKB/TrEMBL
    A6KQR1

  7. XM_063267066.1 → XP_063123136.1  protein GPR108 isoform X6

    UniProtKB/TrEMBL
    A6KQR1
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6P6V6.2 GenPept UniProtKB/Swiss-Prot:Q6P6V6

Gene LinkOut

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