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Sult1c2a sulfotransferase family 1C member 2A [ Rattus norvegicus (Norway rat) ]

Gene ID: 316153, updated on 10-Jul-2024

Summary

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Official Symbol
Sult1c2aprovided by RGD
Official Full Name
sulfotransferase family 1C member 2Aprovided by RGD
Primary source
RGD:1305885
See related
EnsemblRapid:ENSRNOG00000042111 AllianceGenome:RGD:1305885
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
ST1C2A; Sult1c1; RGD1562392; RGD1565421
Summary
Enables aryl sulfotransferase activity. Involved in sulfation. Located in lysosome. Orthologous to human SULT1C2 (sulfotransferase family 1C member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward (RPKM 6322.9) See more
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Genomic context

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See Sult1c2a in Genome Data Viewer
Location:
9q11
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (7075873..7103316, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (6873697..6904736, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (4152588..4168355, complement)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4932415M13 gene like Neighboring gene sulfotransferase 1C2-like Neighboring gene brain acid soluble protein 1-like Neighboring gene sulfotransferase 1C2A-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Enzymatic properties, tissue-specific expression, and lysosomal location of two highly homologous rat SULT1C2 sulfotransferases. Xiangrong L, et al. Biochem Biophys Res Commun, 2000 May 27. PMID 10872834
  2. Expression of the sulfotransferase 1C family: implications for xenobiotic toxicity. Runge-Morris M, et al. Drug Metab Rev, 2013 Nov. PMID 24028175
  3. Inhibitory effects of kynurenic acid, a tryptophan metabolite, and its derivatives on cytosolic sulfotransferases. Senggunprai L, et al. Biochem J, 2009 Aug 27. PMID 19548878
  4. Phase II metabolism of hesperetin by individual UDP-glucuronosyltransferases and sulfotransferases and rat and human tissue samples. Brand W, et al. Drug Metab Dispos, 2010 Apr. PMID 20056724
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC108549

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables aryl sulfotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables aryl sulfotransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables aryl sulfotransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables aryl sulfotransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables sulfotransferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in sulfation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sulfation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in sulfation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within sulfation ISO
Inferred from Sequence Orthology
more info
  
involved_in sulfation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lysosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in lysosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
sulfotransferase 1C2A
Names
rSULT1C2A
sulfotransferase 1C2
sulfotransferase K2
sulfotransferase K2-like
sulfotransferase family, cytosolic, 1C, member 1
sulfotransferase family, cytosolic, 1C, member 2a
XP_038939397.2
XP_038939398.2
XP_038939399.2
XP_038939400.2
XP_063123137.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013177.3 → NP_001013195.3  sulfotransferase 1C2A isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/Swiss-Prot
    Q569D0, Q642G8, Q9WUW9

  2. NM_001428986.1 → NP_001415915.1  sulfotransferase 1C2A isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/Swiss-Prot
    Q569D0, Q642G8, Q9WUW9

  3. NM_001428987.1 → NP_001415916.1  sulfotransferase 1C2A isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/Swiss-Prot
    Q569D0, Q642G8, Q9WUW9

  4. NM_001428988.1 → NP_001415917.1  sulfotransferase 1C2A isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/Swiss-Prot
    Q569D0, Q642G8, Q9WUW9

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    7075873..7103316 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039083469.2 → XP_038939397.2  sulfotransferase 1C2A isoform X1

  2. XM_039083471.2 → XP_038939399.2  sulfotransferase 1C2A isoform X1

    UniProtKB/Swiss-Prot
    Q569D0, Q642G8, Q9WUW9
    Related
    ENSRNOP00000096879.2, ENSRNOT00000106188.2

  3. XM_039083470.2 → XP_038939398.2  sulfotransferase 1C2A isoform X1

    UniProtKB/Swiss-Prot
    Q569D0, Q642G8, Q9WUW9

  4. XM_039083472.2 → XP_038939400.2  sulfotransferase 1C2A isoform X2

    Related
    ENSRNOP00000058577.6, ENSRNOT00000061861.6

  5. XM_063267067.1 → XP_063123137.1  sulfotransferase 1C2A isoform X2

    UniProtKB/Swiss-Prot
    Q569D0, Q642G8, Q9WUW9
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9WUW9.2 GenPept UniProtKB/Swiss-Prot:Q9WUW9

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