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Tuba4a tubulin, alpha 4A [ Rattus norvegicus (Norway rat) ]

Gene ID: 316531, updated on 14-Nov-2024

Summary

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Official Symbol
Tuba4aprovided by RGD
Official Full Name
tubulin, alpha 4Aprovided by RGD
Primary source
RGD:1359623
See related
EnsemblRapid:ENSRNOG00000003597 AllianceGenome:RGD:1359623
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Tuba4
Summary
Predicted to enable GTP binding activity and protein kinase binding activity. Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in microtubule cytoskeleton organization and mitotic cell cycle. Predicted to be located in microtubule cytoskeleton. Predicted to be active in cytoplasm and microtubule. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 22. Orthologous to human TUBA4A (tubulin alpha 4a). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Muscle (RPKM 1136.6), Heart (RPKM 991.9) and 7 other tissues See more
Orthologs
human all
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Genomic context

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See Tuba4a in Genome Data Viewer
Location:
9q33
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (84158871..84174041, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (76709617..76714327, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (82415599..82419918, complement)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene ankyrin repeat and zinc finger peptidyl tRNA hydrolase 1 Neighboring gene galactosidase, beta 1-like Neighboring gene serine/threonine kinase 16 Neighboring gene uncharacterized LOC102554903 Neighboring gene DnaJ heat shock protein family (Hsp40) member B2 Neighboring gene uncharacterized LOC120094712 Neighboring gene protein tyrosine phosphatase, receptor type, N

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A revised nomenclature for the human and rodent alpha-tubulin gene family. Khodiyar VK, et al. Genomics, 2007 Aug. PMID 17543498
  2. Interplay between structure-specific endonucleases for crossover control during Caenorhabditis elegans meiosis. Saito TT, et al. PLoS Genet, 2013. PMID 23874210, Free PMC Article
  3. Six mouse alpha-tubulin mRNAs encode five distinct isotypes: testis-specific expression of two sister genes. Villasante A, et al. Mol Cell Biol, 1986 Jul. PMID 3785200, Free PMC Article
  4. Intracellular distribution of differentially phosphorylated dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A). Kaczmarski W, et al. J Neurosci Res, 2014 Feb. PMID 24327345, Free PMC Article
  5. PEX14 is required for microtubule-based peroxisome motility in human cells. Bharti P, et al. J Cell Sci, 2011 May 15. PMID 21525035

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC94628

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables structural constituent of cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
  
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule-based process IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in motile cilium IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
tubulin alpha-4A chain
Names
alpha-tubulin 4
tubulin alpha-4 chain
tubulin, alpha 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007004.2 → NP_001007005.1  tubulin alpha-4A chain

    See identical proteins and their annotated locations for NP_001007005.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/Swiss-Prot
    Q5XIF6
    UniProtKB/TrEMBL
    A0A8I6ALV8, A6JVZ9
    Related
    ENSRNOP00000004797.5, ENSRNOT00000004797.7
    Conserved Domains (1) summary
    PTZ00335
    Location:1 → 448
    PTZ00335; tubulin alpha chain; Provisional

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    84158871..84174041 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063267230.1 → XP_063123300.1  tubulin alpha-4A chain isoform X1

    UniProtKB/Swiss-Prot
    Q5XIF6
    UniProtKB/TrEMBL
    A6JVZ9

  2. XM_006245227.4 → XP_006245289.1  tubulin alpha-4A chain isoform X2

    See identical proteins and their annotated locations for XP_006245289.1

    UniProtKB/TrEMBL
    A0A8I6ALV8
    Conserved Domains (1) summary
    PTZ00335
    Location:1 → 433
    PTZ00335; tubulin alpha chain; Provisional

  3. XM_063267231.1 → XP_063123301.1  tubulin alpha-4A chain isoform X2

    Related
    ENSRNOP00000101677.1, ENSRNOT00000127189.1

  4. XM_039083681.2 → XP_038939609.1  tubulin alpha-4A chain isoform X2

    UniProtKB/TrEMBL
    A0A8I6ALV8
    Conserved Domains (1) summary
    PTZ00335
    Location:1 → 433
    PTZ00335; tubulin alpha chain; Provisional
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5XIF6.1 GenPept UniProtKB/Swiss-Prot:Q5XIF6

Gene LinkOut

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