coro1ca coronin, actin binding protein, 1Ca [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: coro1caprovided by ZNC
Official Full Name: coronin, actin binding protein, 1Caprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030114-6
See related: Ensembl:ENSDARG00000035598 AllianceGenome:ZFIN:ZDB-GENE-030114-6
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb655; coro1c; zC108C6.3; wu:fa99e02; wu:fb30g03; wu:fc60a02; wu:fi35a01; zC191D15.1
Summary: Predicted to enable actin filament binding activity. Involved in neural crest cell migration. Predicted to be located in endosome membrane. Is expressed in several structures, including digestive system; nervous system; neural tube; periderm; and solid lens vesicle. Orthologous to human CORO1C (coronin 1C). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 5

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (20319544..20416822)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (19815744..19913022)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fc60a02 (e-PCR)
- UniSTS:189453

fb30g03 (e-PCR)
- UniSTS:189014

fa99e02.x1 (e-PCR)
- UniSTS:202636

fi35a01.x1 (e-PCR)
- UniSTS:197355

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in endosomal transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in endosome fission	ISS Inferred from Sequence or Structural Similarity more info
involved_in endosome membrane tubulation	ISS Inferred from Sequence or Structural Similarity more info
involved_in membrane fission	ISS Inferred from Sequence or Structural Similarity more info
involved_in neural crest cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in neural crest cell migration	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell cortex	IEA Inferred from Electronic Annotation more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in endosome membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in lamellipodium	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in ruffle membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: coronin-1C-A

Names: coronin, actin binding protein, 1C; coronin-1C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_201295.1 → NP_958452.1 coronin-1C-A

See identical proteins and their annotated locations for NP_958452.1

Status: PROVISIONAL

Source sequence(s)

BC045340

UniProtKB/Swiss-Prot

B0R0D7, Q7ZW06

Related

ENSDARP00000026454.8, ENSDART00000004217.9

Conserved Domains (5) summary

PTZ00421
Location:9 → 471

PTZ00421; coronin; Provisional

pfam08953
Location:7 → 64

DUF1899; Domain of unknown function (DUF1899)

pfam16300
Location:344 → 386

WD40_4; Type of WD40 repeat

sd00039
Location:37 → 79

7WD40; WD40 repeat [structural motif]

cl02567
Location:76 → 301

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...