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Zfp653 zinc finger protein 653 [ Mus musculus (house mouse) ]

Gene ID: 319601, updated on 2-Nov-2024

Summary

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Official Symbol
Zfp653provided by MGI
Official Full Name
zinc finger protein 653provided by MGI
Primary source
MGI:MGI:2442362
See related
Ensembl:ENSMUSG00000038895 AllianceGenome:MGI:2442362
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Zip67; Znf653; E430039K05Rik
Summary
Predicted to enable AF-2 domain binding activity; DNA-binding transcription factor binding activity; and transcription corepressor activity. Predicted to be involved in extracellular negative regulation of signal transduction and negative regulation of transcription by RNA polymerase II. Predicted to be located in extracellular region. Predicted to be active in nucleus. Is expressed in early conceptus and genitourinary system. Orthologous to human ZNF653 (zinc finger protein 653). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in testis adult (RPKM 17.9), ovary adult (RPKM 17.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Zfp653 in Genome Data Viewer
Location:
9 A3; 9 8.18 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (21966705..21982707, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (22055411..22071395, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene protein kinase C substrate 80K-H Neighboring gene ELAV like RNA binding protein 3 Neighboring gene predicted gene, 16845 Neighboring gene ECSIT signalling integrator Neighboring gene STARR-positive B cell enhancer ABC_E8280 Neighboring gene predicted gene 6581

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cloning and characterization of a novel zinc finger protein that modulates the transcriptional activity of nuclear receptors. Borud B, et al. Mol Endocrinol, 2003 Nov. PMID 12920234
  2. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
  3. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
  4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  5. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. novel zinc-finger protein that influences gene activation through interaction with the functionally important activation function-2 domain of nuclear receptors
    Title: Cloning and characterization of a novel zinc finger protein that modulates the transcriptional activity of nuclear receptors.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables AF-2 domain binding IEA
Inferred from Electronic Annotation
more info
  
enables AF-2 domain binding ISO
Inferred from Sequence Orthology
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription corepressor activity ISO
Inferred from Sequence Orthology
more info
  
enables transcription corepressor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in extracellular negative regulation of signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in extracellular negative regulation of signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger protein 653
Names
67 kDa zinc finger protein
zinc finger protein Zip67

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310759.2 → NP_001297688.1  zinc finger protein 653 isoform 1

    See identical proteins and their annotated locations for NP_001297688.1

    Status: VALIDATED

    Source sequence(s)
    AC163623
    Consensus CDS
    CCDS80968.1
    UniProtKB/TrEMBL
    Q8BHR7
    Related
    ENSMUSP00000137064.2, ENSMUST00000179605.9
    Conserved Domains (3) summary
    COG5048
    Location:494 → 622
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:511 → 530
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:522 → 547
    zf-H2C2_2; Zinc-finger double domain

  2. NM_177318.4 → NP_796292.1  zinc finger protein 653 isoform 2

    See identical proteins and their annotated locations for NP_796292.1

    Status: VALIDATED

    Source sequence(s)
    AC163623
    Consensus CDS
    CCDS22919.1
    UniProtKB/Swiss-Prot
    Q6YND2, Q8BHT8, Q8CI02
    Related
    ENSMUSP00000045895.7, ENSMUST00000043922.7
    Conserved Domains (3) summary
    COG5048
    Location:486 → 614
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:503 → 522
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:514 → 539
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    21966705..21982707 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006510407.4 → XP_006510470.1  zinc finger protein 653 isoform X1

    Conserved Domains (1) summary
    pfam04979
    Location:391 → 444
    IPP-2; Protein phosphatase inhibitor 2 (IPP-2)

  2. XM_036155049.1 → XP_036010942.1  zinc finger protein 653 isoform X2

RNA

  1. XR_001778929.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6YND2.2 GenPept UniProtKB/Swiss-Prot:Q6YND2

Gene LinkOut

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