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Atp10b ATPase, class V, type 10B [ Mus musculus (house mouse) ]

Gene ID: 319767, updated on 11-Apr-2024

Summary

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Official Symbol
Atp10bprovided by MGI
Official Full Name
ATPase, class V, type 10Bprovided by MGI
Primary source
MGI:MGI:2442688
See related
Ensembl:ENSMUSG00000055415 AllianceGenome:MGI:2442688
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
5930426O13Rik; 9030605H24Rik
Summary
Predicted to enable glycosylceramide flippase activity and phosphatidylcholine flippase activity. Predicted to be involved in lysosomal membrane organization and phospholipid translocation. Predicted to be located in endoplasmic reticulum. Predicted to be integral component of lysosomal membrane. Predicted to be part of phospholipid-translocating ATPase complex. Predicted to be active in plasma membrane. Orthologous to human ATP10B (ATPase phospholipid transporting 10B (putative)). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in genital fat pad adult (RPKM 11.0), large intestine adult (RPKM 9.6) and 6 other tissues See more
Orthologs
human all
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Genomic context

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See Atp10b in Genome Data Viewer
Location:
11 A5; 11 25.68 cM
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (42902991..43153112)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (43012164..43262285)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 34591 Neighboring gene gamma-aminobutyric acid type A receptor subunit beta 2 Neighboring gene STARR-seq mESC enhancer starr_29249 Neighboring gene STARR-seq mESC enhancer starr_29250 Neighboring gene STARR-seq mESC enhancer starr_29251 Neighboring gene predicted gene, 34644 Neighboring gene STARR-seq mESC enhancer starr_29252 Neighboring gene STARR-seq mESC enhancer starr_29253 Neighboring gene STARR-positive B cell enhancer mm9_chr11:42987971-42988272 Neighboring gene predicted gene 12146 Neighboring gene predicted gene, 51418 Neighboring gene STARR-positive B cell enhancer ABC_E11475 Neighboring gene STARR-positive B cell enhancer mm9_chr11:43172342-43172643 Neighboring gene STARR-positive B cell enhancer ABC_E9138 Neighboring gene microRNA 146 Neighboring gene predicted gene 5782

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  2. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  3. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATPase-coupled intramembrane lipid transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glycosylceramide flippase activity ISO
Inferred from Sequence Orthology
more info
  
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylcholine flippase activity ISO
Inferred from Sequence Orthology
more info
  
enables transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in lysosomal membrane organization ISO
Inferred from Sequence Orthology
more info
  
involved_in phospholipid translocation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phospholipid transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in late endosome membrane ISO
Inferred from Sequence Orthology
more info
  
located_in lysosomal membrane ISO
Inferred from Sequence Orthology
more info
  
located_in lysosome IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
part_of phospholipid-translocating ATPase complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
phospholipid-transporting ATPase VB
Names
potential phospholipid-transporting ATPase VB
probable phospholipid-transporting ATPase VB
NP_795973.2
XP_006533597.1
XP_017170095.1
XP_036012652.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001428744.1 → NP_001415673.1  phospholipid-transporting ATPase VB

    Status: VALIDATED

    Source sequence(s)
    AL672181, AL772227, AL935157
    UniProtKB/Swiss-Prot
    B1AWN4

  2. NM_176999.4 → NP_795973.2  phospholipid-transporting ATPase VB

    See identical proteins and their annotated locations for NP_795973.2

    Status: VALIDATED

    Source sequence(s)
    AL772227, AL935157
    Consensus CDS
    CCDS36129.1
    UniProtKB/Swiss-Prot
    B1AWN4
    Related
    ENSMUSP00000076844.6, ENSMUST00000077659.6
    Conserved Domains (1) summary
    cd02073
    Location:68 → 1211
    P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    42902991..43153112
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017314606.2 → XP_017170095.1  phospholipid-transporting ATPase VB isoform X1

    Conserved Domains (1) summary
    cd02073
    Location:68 → 1211
    P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C

  2. XM_036156759.1 → XP_036012652.1  phospholipid-transporting ATPase VB isoform X3

    Conserved Domains (1) summary
    cl21460
    Location:1 → 1105
    HAD_like; Haloacid Dehalogenase-like Hydrolases

  3. XM_006533534.4 → XP_006533597.1  phospholipid-transporting ATPase VB isoform X2

    UniProtKB/TrEMBL
    A0A571BEJ2
    Related
    ENSMUSP00000158770.2, ENSMUST00000238415.2
    Conserved Domains (1) summary
    cd02073
    Location:40 → 1183
    P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B1AWN4.1 GenPept UniProtKB/Swiss-Prot:B1AWN4

Gene LinkOut

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