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Ddx11 DEAD/H box helicase 11 [ Mus musculus (house mouse) ]

Gene ID: 320209, updated on 9-Aug-2024

Summary

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Official Symbol
Ddx11provided by MGI
Official Full Name
DEAD/H box helicase 11provided by MGI
Primary source
MGI:MGI:2443590
See related
Ensembl:ENSMUSG00000035842 AllianceGenome:MGI:2443590
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CHL1; KRG2; CHLR1; essa15a; 4732462I11Rik
Summary
Predicted to enable several functions, including 5'-3' DNA helicase activity; ATP-dependent activity, acting on RNA; and nucleic acid binding activity. Predicted to be involved in DNA duplex unwinding and establishment of sister chromatid cohesion. Predicted to act upstream of or within DNA repair and DNA replication. Predicted to be located in several cellular components, including microtubule cytoskeleton; midbody; and nuclear lumen. Predicted to be part of Ctf18 RFC-like complex. Predicted to be active in nucleus. Is expressed in allantois; embryo; placenta; and yolk sac endoderm. Human ortholog(s) of this gene implicated in Warsaw breakage syndrome. Orthologous to several human genes including DDX11 (DEAD/H-box helicase 11). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 7.2), limb E14.5 (RPKM 5.7) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Ddx11 in Genome Data Viewer
Location:
17 E1.1; 17 35.26 cM
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (66430508..66459169)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (66123513..66152174)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene NADH:ubiquinone oxidoreductase core subunit V2 Neighboring gene predicted gene, 23264 Neighboring gene STARR-seq mESC enhancer starr_43041 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:66456304-66456487 Neighboring gene STARR-positive B cell enhancer ABC_E10966 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:66460812-66460921 Neighboring gene WASH complex subunit 1 Neighboring gene STARR-positive B cell enhancer ABC_E7552 Neighboring gene STARR-seq mESC enhancer starr_43043 Neighboring gene STARR-seq mESC enhancer starr_43044 Neighboring gene STARR-seq mESC enhancer starr_43045 Neighboring gene putative sperm motility kinase W Neighboring gene predicted gene, 20742

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Loss of ChlR1 helicase in mouse causes lethality due to the accumulation of aneuploid cells generated by cohesion defects and placental malformation. Inoue A, et al. Cell Cycle, 2007 Jul 1. PMID 17611414
  2. Mammalian ChlR1 has a role in heterochromatin organization. Inoue A, et al. Exp Cell Res, 2011 Oct 15. PMID 21854770, Free PMC Article
  3. The ENU-induced cetus mutation reveals an essential role of the DNA helicase DDX11 for mesoderm development during early mouse embryogenesis. Cota CD, et al. Dev Dyn, 2012 Aug. PMID 22678773
  4. Analysis of mouse embryonic patterning and morphogenesis by forward genetics. García-García MJ, et al. Proc Natl Acad Sci U S A, 2005 Apr 26. PMID 15755804, Free PMC Article
  5. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ChlR1 is essential for embryonic development and the prevention of aneuploidy in mammals.
    Title: Loss of ChlR1 helicase in mouse causes lethality due to the accumulation of aneuploid cells generated by cohesion defects and placental malformation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Clone Names

  • MGC90809

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 4 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables 5'-3' DNA helicase activity ISO
Inferred from Sequence Orthology
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent activity, acting on DNA ISO
Inferred from Sequence Orthology
more info
  
enables ATP-dependent activity, acting on RNA ISO
Inferred from Sequence Orthology
more info
  
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables DNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA helicase activity ISO
Inferred from Sequence Orthology
more info
  
enables DNA replication origin binding ISO
Inferred from Sequence Orthology
more info
  
enables G-quadruplex DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
  
enables double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables helicase activity ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides IEA
Inferred from Electronic Annotation
more info
  
enables iron-sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables single-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables single-stranded RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables triplex DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA duplex unwinding IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in establishment of sister chromatid cohesion IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
involved_in nucleobase-containing compound metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of Ctf18 RFC-like complex ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
part_of chromatin ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in midbody ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
colocalizes_with nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in spindle pole ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ATP-dependent DNA helicase DDX11
Names
DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11 (CHL1-like helicase homolog, S. cerevisiae)
DNA 5'-3' helicase DDX11
probable ATP-dependent RNA helicase DDX11
NP_001003919.1
NP_001335221.1
XP_006524472.1
XP_006524473.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003919.2 → NP_001003919.1  ATP-dependent DNA helicase DDX11 isoform 1

    See identical proteins and their annotated locations for NP_001003919.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) uses an alternate in-frame splice site in the 5' coding region compared to variant 2. The encoded isoform (1) is shorter than isoform 2.
    Source sequence(s)
    BC079656, CT025671
    Consensus CDS
    CCDS28945.1
    UniProtKB/TrEMBL
    A0A2Y9CZM3
    Related
    ENSMUSP00000130440.3, ENSMUST00000163605.3
    Conserved Domains (3) summary
    TIGR00604
    Location:199 → 863
    rad3; DNA repair helicase (rad3)
    pfam13307
    Location:664 → 853
    Helicase_C_2; Helicase C-terminal domain
    cl21455
    Location:22 → 408
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  2. NM_001348292.1 → NP_001335221.1  ATP-dependent DNA helicase DDX11 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents the longer transcript and encodes the longer isoform (2).
    Source sequence(s)
    AK152868, BC079656, CT025671
    Consensus CDS
    CCDS89137.1
    UniProtKB/Swiss-Prot
    A0A286YDJ5, Q6AXC6
    Related
    ENSMUSP00000153436.2, ENSMUST00000224497.2
    Conserved Domains (1) summary
    TIGR00604
    Location:225 → 889
    rad3; DNA repair helicase (rad3)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    66430508..66459169
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006524410.5 → XP_006524473.1  ATP-dependent DNA helicase DDX11 isoform X2

    Conserved Domains (1) summary
    cl28899
    Location:22 → 434
    DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily

  2. XM_006524409.4 → XP_006524472.1  ATP-dependent DNA helicase DDX11 isoform X1

    See identical proteins and their annotated locations for XP_006524472.1

    UniProtKB/Swiss-Prot
    A0A286YDJ5, Q6AXC6
    Conserved Domains (1) summary
    TIGR00604
    Location:225 → 889
    rad3; DNA repair helicase (rad3)

RNA

  1. XR_003952132.2 RNA Sequence

  2. XR_385336.5 RNA Sequence

    Related
    ENSMUST00000225687.2
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6AXC6.2 GenPept UniProtKB/Swiss-Prot:Q6AXC6

Gene LinkOut

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