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Strip2 striatin interacting protein 2 [ Mus musculus (house mouse) ]

Gene ID: 320609, updated on 9-Dec-2024

Summary

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Official Symbol
Strip2provided by MGI
Official Full Name
striatin interacting protein 2provided by MGI
Primary source
MGI:MGI:2444363
See related
Ensembl:ENSMUSG00000039629 AllianceGenome:MGI:2444363
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fam40b; Myoscape; D330017J20Rik
Summary
Predicted to be involved in cell migration; cytoskeleton organization; and regulation of cell shape. Predicted to be located in cytoplasm. Predicted to be part of FAR/SIN/STRIPAK complex. Predicted to be active in cytosol. Is expressed in brain and cochlea epithelium. Orthologous to human STRIP2 (striatin interacting protein 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in cerebellum adult (RPKM 10.2), heart adult (RPKM 8.4) and 10 other tissues See more
Orthologs
human all
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Genomic context

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See Strip2 in Genome Data Viewer
Location:
6 A3.3; 6 12.36 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (29916975..29959680)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (29916976..29959681)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene smoothened, frizzled class receptor Neighboring gene predicted gene 13717 Neighboring gene STARR-positive B cell enhancer ABC_E677 Neighboring gene STARR-seq mESC enhancer starr_15451 Neighboring gene S-adenosylhomocysteine hydrolase-like 2 Neighboring gene STARR-positive B cell enhancer mm9_chr6:29783505-29783805 Neighboring gene STARR-positive B cell enhancer mm9_chr6:29787542-29787842 Neighboring gene STARR-positive B cell enhancer mm9_chr6:29788430-29788731 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:29847059-29847242 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:29847325-29847478 Neighboring gene STARR-positive B cell enhancer ABC_E4816 Neighboring gene predicted gene, 52897 Neighboring gene phosphoglycerate kinase 1 pseudogene Neighboring gene predicted gene, 24536

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Myoscape controls cardiac calcium cycling and contractility via regulation of L-type calcium channel surface expression. Eden M, et al. Nat Commun, 2016 Apr 28. PMID 27122098, Free PMC Article
  2. Fam40b is required for lineage commitment of murine embryonic stem cells. Wagh V, et al. Cell Death Dis, 2014 Jul 10. PMID 25010986, Free PMC Article
  3. Gene Expression by Mouse Inner Ear Hair Cells during Development. Scheffer DI, et al. J Neurosci, 2015 Apr 22. PMID 25904789, Free PMC Article
  4. Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Feb 28. PMID 12693553
  5. A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Thompson CL, et al. Neuron, 2014 Jul 16. PMID 24952961, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Myoscape/FAM40B/STRIP2 knockout (KO) mice display impairment of cardiac function progressing to advanced heart failure.
    Title: Myoscape controls cardiac calcium cycling and contractility via regulation of L-type calcium channel surface expression.
  2. Fam40b is essential for the lineage commitment of murine embryonic stem cells into differentiated somatic cells.
    Title: Fam40b is required for lineage commitment of murine embryonic stem cells.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA1170

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in cell migration ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in cytoskeleton organization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of cell shape ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell shape ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of FAR/SIN/STRIPAK complex ISO
Inferred from Sequence Orthology
more info
  
part_of FAR/SIN/STRIPAK complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
striatin-interacting proteins 2
Names
family with sequence similarity 40, member B
protein FAM40B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037740.1 → NP_001032829.1  striatin-interacting proteins 2 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. It encodes isoform (b) which is shorter than isoform a.
    Source sequence(s)
    AC079216, AK042073, AK122459
    Consensus CDS
    CCDS85025.1
    UniProtKB/TrEMBL
    E9QN41
    Related
    ENSMUSP00000119506.3, ENSMUST00000151738.4
    Conserved Domains (2) summary
    pfam07923
    Location:58 → 348
    N1221; N1221-like protein
    pfam11882
    Location:466 → 763
    DUF3402; Domain of unknown function (DUF3402)

  2. NM_177204.3 → NP_796178.2  striatin-interacting proteins 2 isoform a

    See identical proteins and their annotated locations for NP_796178.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AC079216, AK042073
    Consensus CDS
    CCDS19967.1
    UniProtKB/Swiss-Prot
    Q3TQB7, Q80TI6, Q8C7A2, Q8C9H6
    UniProtKB/TrEMBL
    B2RW20
    Related
    ENSMUSP00000036477.7, ENSMUST00000046028.12
    Conserved Domains (2) summary
    pfam07923
    Location:58 → 348
    N1221; N1221-like protein
    pfam11882
    Location:466 → 791
    DUF3402; Domain of unknown function (DUF3402)

RNA

  1. NR_104576.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK042073, AK052188, AK052273, BE988014

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    29916975..29959680
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006505118.4 → XP_006505181.1  striatin-interacting proteins 2 isoform X1

    UniProtKB/TrEMBL
    E9QN41
    Conserved Domains (2) summary
    pfam07923
    Location:58 → 348
    N1221; N1221-like protein
    pfam11882
    Location:466 → 694
    DUF3402; Domain of unknown function (DUF3402)

  2. XM_011241067.2 → XP_011239369.1  striatin-interacting proteins 2 isoform X2

    See identical proteins and their annotated locations for XP_011239369.1

    UniProtKB/TrEMBL
    E9QN41
    Conserved Domains (2) summary
    pfam07923
    Location:58 → 348
    N1221; N1221-like protein
    pfam11882
    Location:466 → 635
    DUF3402; Domain of unknown function (DUF3402)

  3. XM_011241068.3 → XP_011239370.1  striatin-interacting proteins 2 isoform X2

    See identical proteins and their annotated locations for XP_011239370.1

    UniProtKB/TrEMBL
    E9QN41
    Related
    ENSMUSP00000110879.3, ENSMUST00000115224.8
    Conserved Domains (2) summary
    pfam07923
    Location:58 → 348
    N1221; N1221-like protein
    pfam11882
    Location:466 → 635
    DUF3402; Domain of unknown function (DUF3402)

  4. XM_011241069.2 → XP_011239371.1  striatin-interacting proteins 2 isoform X3

    Conserved Domains (2) summary
    pfam07923
    Location:60 → 140
    N1221; N1221-like protein
    pfam11882
    Location:274 → 600
    DUF3402; Domain of unknown function (DUF3402)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C9H6.1 GenPept UniProtKB/Swiss-Prot:Q8C9H6

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