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Amigo3 adhesion molecule with Ig like domain 3 [ Mus musculus (house mouse) ]

Gene ID: 320844, updated on 17-Aug-2024

Summary

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Official Symbol
Amigo3provided by MGI
Official Full Name
adhesion molecule with Ig like domain 3provided by MGI
Primary source
MGI:MGI:2444854
See related
Ensembl:ENSMUSG00000032593 AllianceGenome:MGI:2444854
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ali3; mKIAA1851; E430002N15Rik
Summary
Acts upstream of or within positive regulation of synapse assembly. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in several structures, including brain; gut; hemolymphoid system gland; reproductive system; and trigeminal nerve. Orthologous to human AMIGO3 (adhesion molecule with Ig like domain 3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human all
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Genomic context

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See Amigo3 in Genome Data Viewer
Location:
9 F1; 9 59.07 cM
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (107930358..107932900)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (108053159..108055701)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E61 Neighboring gene inositol hexaphosphate kinase 1 Neighboring gene STARR-positive B cell enhancer ABC_E2305 Neighboring gene STARR-positive B cell enhancer ABC_E6803 Neighboring gene STARR-positive B cell enhancer ABC_E3859 Neighboring gene GDP-mannose pyrophosphorylase B Neighboring gene ring finger protein 123 Neighboring gene microRNA 7088 Neighboring gene macrophage stimulating 1 (hepatocyte growth factor-like) Neighboring gene STARR-positive B cell enhancer ABC_E2914 Neighboring gene acylpeptide hydrolase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Alivin 1, a novel neuronal activity-dependent gene, inhibits apoptosis and promotes survival of cerebellar granule neurons. Ono T, et al. J Neurosci, 2003 Jul 2. PMID 12843293, Free PMC Article
  2. AMIGO, a transmembrane protein implicated in axon tract development, defines a novel protein family with leucine-rich repeats. Kuja-Panula J, et al. J Cell Biol, 2003 Mar 17. PMID 12629050, Free PMC Article
  3. Expression pattern of LRR and Ig domain-containing protein (LRRIG protein) in the early mouse embryo. Homma S, et al. Gene Expr Patterns, 2009 Jan. PMID 18848646
  4. Calsyntenins function as synaptogenic adhesion molecules in concert with neurexins. Um JW, et al. Cell Rep, 2014 Mar 27. PMID 24613359, Free PMC Article
  5. Expression of the immunoglobulin superfamily cell adhesion molecules in the developing spinal cord and dorsal root ganglion. Gu Z, et al. PLoS One, 2015. PMID 25826454, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in brain development IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cell adhesion ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules ISO
Inferred from Sequence Orthology
more info
  
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in negative regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
  
involved_in nervous system development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of synapse assembly IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
amphoterin-induced protein 3
Names
AMIGO-3
alivin 3
amphoterin induced gene and ORF 3
NP_796249.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177275.4 → NP_796249.1  amphoterin-induced protein 3 precursor

    See identical proteins and their annotated locations for NP_796249.1

    Status: VALIDATED

    Source sequence(s)
    AB167510, AC137678, AI413948
    Consensus CDS
    CCDS23516.1
    UniProtKB/Swiss-Prot
    Q6ZPH1, Q8C2S7, Q8CEB3
    Related
    ENSMUSP00000082137.3, ENSMUST00000085060.3
    Conserved Domains (4) summary
    smart00410
    Location:286 → 371
    IG_like; Immunoglobulin like
    cd00116
    Location:49 → 221
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:65 → 86
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:65 → 121
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    107930358..107932900
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C2S7.1 GenPept UniProtKB/Swiss-Prot:Q8C2S7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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