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Cdh10 cadherin 10 [ Mus musculus (house mouse) ]

Gene ID: 320873, updated on 9-Dec-2024

Summary

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Official Symbol
Cdh10provided by MGI
Official Full Name
cadherin 10provided by MGI
Primary source
MGI:MGI:107436
See related
Ensembl:ENSMUSG00000022321 AllianceGenome:MGI:107436
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
A830016G23Rik; C030003B10Rik; C030011H18Rik
Summary
This gene encodes a member of the cadherin family of calcium-dependent glycoproteins that mediate cell adhesion and regulate many morphogenetic events during development. The encoded preproprotein is further processed to generate a mature protein. This gene is expressed in the blood-brain barrier and retinal endothelia suggesting a role in the development and maintenance of brain barrier. Alternative splicing results in multiple transcript variants. Multiple distinct genes of the cadherin family, including this gene, are found on chromosome 15. [provided by RefSeq, Oct 2015]
Expression
Biased expression in frontal lobe adult (RPKM 9.2), CNS E18 (RPKM 8.6) and 7 other tissues See more
Orthologs
human all
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Genomic context

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See Cdh10 in Genome Data Viewer
Location:
15 A2; 15 8.2 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (18818763..19014883)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (18818869..19016206)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4921515E04 gene Neighboring gene predicted gene, 41277 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene STARR-seq mESC enhancer starr_38099 Neighboring gene STARR-seq mESC enhancer starr_38100 Neighboring gene RIKEN cDNA C030047K22 gene Neighboring gene STARR-seq mESC enhancer starr_38101 Neighboring gene STARR-seq mESC enhancer starr_38102 Neighboring gene STARR-seq mESC enhancer starr_38105 Neighboring gene malignant T cell amplified sequence 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_38106 Neighboring gene predicted gene, 35496

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cadherin-10 is a novel blood-brain barrier adhesion molecule in human and mouse. Williams MJ, et al. Brain Res, 2005 Oct 5. PMID 16181616
  2. Heterophilic Type II Cadherins Are Required for High-Magnitude Synaptic Potentiation in the Hippocampus. Basu R, et al. Neuron, 2017 Sep 27. PMID 28957665, Free PMC Article
  3. Cadherins Interact With Synaptic Organizers to Promote Synaptic Differentiation. Yamagata M, et al. Front Mol Neurosci, 2018. PMID 29760652, Free PMC Article
  4. Cadherin Combinations Recruit Dendrites of Distinct Retinal Neurons to a Shared Interneuronal Scaffold. Duan X, et al. Neuron, 2018 Sep 19. PMID 30197236, Free PMC Article
  5. Characterization of cadherins expressed by murine thymocytes. Munro SB, et al. Cell Immunol, 1996 May 1. PMID 8620560

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (3)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables beta-catenin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cadherin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in adherens junction organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell-cell adhesion mediated by cadherin IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell-cell junction assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in homophilic cell adhesion via plasma membrane adhesion molecules IEA
Inferred from Electronic Annotation
more info
  
involved_in synaptic membrane adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in synaptic membrane adhesion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in synaptic membrane adhesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in GABA-ergic synapse IEA
Inferred from Electronic Annotation
more info
  
is_active_in GABA-ergic synapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in adherens junction IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of catenin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in postsynaptic specialization membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in postsynaptic specialization membrane ISO
Inferred from Sequence Orthology
more info
  
located_in presynaptic active zone membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in presynaptic active zone membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
cadherin-10
Names
T2-cadherin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001316758.1 → NP_001303687.1  cadherin-10 preproprotein

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC121768, AK138606, BB649070, BC052056
    Consensus CDS
    CCDS37047.1
    UniProtKB/Swiss-Prot
    P70408, Q3UUB3, Q80WS7
    UniProtKB/TrEMBL
    Q8VI68
    Related
    ENSMUSP00000128782.3, ENSMUST00000166873.9
    Conserved Domains (3) summary
    cd11304
    Location:164 → 265
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:80 → 158
    CA; Cadherin repeats
    pfam01049
    Location:643 → 780
    Cadherin_C; Cadherin cytoplasmic region

  2. NM_009865.3 → NP_033995.1  cadherin-10 preproprotein

    See identical proteins and their annotated locations for NP_033995.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK138606, BC052056
    Consensus CDS
    CCDS37047.1
    UniProtKB/Swiss-Prot
    P70408, Q3UUB3, Q80WS7
    UniProtKB/TrEMBL
    Q8VI68
    Related
    ENSMUSP00000042199.8, ENSMUST00000040562.14
    Conserved Domains (3) summary
    cd11304
    Location:164 → 265
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:80 → 158
    CA; Cadherin repeats
    pfam01049
    Location:643 → 780
    Cadherin_C; Cadherin cytoplasmic region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    18818763..19014883
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006520100.5 → XP_006520163.1  cadherin-10 isoform X1

    UniProtKB/TrEMBL
    Q8VI68
    Conserved Domains (3) summary
    cd11304
    Location:164 → 265
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:80 → 158
    CA; Cadherin repeats
    pfam01049
    Location:633 → 780
    Cadherin_C; Cadherin cytoplasmic region
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P70408.3 GenPept UniProtKB/Swiss-Prot:P70408

Gene LinkOut

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