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tmed2 transmembrane p24 trafficking protein 2 [ Danio rerio (zebrafish) ]

Gene ID: 321550, updated on 14-Nov-2024

Summary

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Official Symbol
tmed2provided by ZNC
Official Full Name
transmembrane p24 trafficking protein 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-269
See related
Ensembl:ENSDARG00000026908 AllianceGenome:ZFIN:ZDB-GENE-030131-269
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
Rnp24; fb18g06; zgc:56470; zgc:77725; wu:fb18g06
Summary
Predicted to be involved in Golgi organization; endoplasmic reticulum to Golgi vesicle-mediated transport; and intracellular protein transport. Predicted to act upstream of or within protein transport. Predicted to be located in cytoplasmic vesicle membrane; endoplasmic reticulum membrane; and endoplasmic reticulum-Golgi intermediate compartment membrane. Predicted to be active in several cellular components, including COPII-coated ER to Golgi transport vesicle; Golgi apparatus; and endoplasmic reticulum-Golgi intermediate compartment. Orthologous to human TMED2 (transmembrane p24 trafficking protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See tmed2 in Genome Data Viewer
Location:
chromosome: 10
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (3419832..3427608, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (3419528..3427324, complement)

Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene N-alpha-acetyltransferase 25, NatB auxiliary subunit Neighboring gene DEAD (Asp-Glu-Ala-Asp) box polypeptide 55 Neighboring gene protein tyrosine phosphatase non-receptor type 11a Neighboring gene rabphilin 3A homolog (mouse), a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. A comprehensive overview of the vertebrate p24 family: identification of a novel tissue-specifically expressed member. Strating JR, et al. Mol Biol Evol, 2009 Aug. PMID 19429673
  2. Evolution of JAK-STAT pathway components: mechanisms and role in immune system development. Liongue C, et al. PLoS One, 2012. PMID 22412924, Free PMC Article
  3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum-Golgi intermediate compartment membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transmembrane emp24 domain-containing protein 2
Names
coated vesicle membrane protein
transmembrane emp24 domain trafficking protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199548.2 → NP_955842.1  transmembrane emp24 domain-containing protein 2 precursor

    See identical proteins and their annotated locations for NP_955842.1

    Status: VALIDATED

    Source sequence(s)
    EB783930, EH434412, EH562716
    UniProtKB/TrEMBL
    Q6P0U8, Q7ZW75
    Related
    ENSDARP00000037031.4, ENSDART00000037183.6
    Conserved Domains (1) summary
    pfam01105
    Location:20 → 196
    EMP24_GP25L; emp24/gp25L/p24 family/GOLD

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007121.7 Reference GRCz11 Primary Assembly

    Range
    3419832..3427608 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021479108.2 → XP_021334783.1  transmembrane emp24 domain-containing protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8M9Q5S5
    Related
    ENSDARP00000121973.1, ENSDART00000133452.2
    Conserved Domains (1) summary
    pfam01105
    Location:20 → 203
    EMP24_GP25L; emp24/gp25L/p24 family/GOLD
Nucleotide Protein Strain
Heading Accession and Version

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