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naa35 N-alpha-acetyltransferase 35, NatC auxiliary subunit [ Danio rerio (zebrafish) ]

Gene ID: 321587, updated on 4-Jan-2025

Summary

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Official Symbol
naa35provided by ZNC
Official Full Name
N-alpha-acetyltransferase 35, NatC auxiliary subunitprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-306
See related
Ensembl:ENSDARG00000012378 AllianceGenome:ZFIN:ZDB-GENE-030131-306
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
mak10; zgc:64157; wu:fb21g10
Summary
Acts upstream of or within several processes, including blood vessel morphogenesis; regulation of TOR signaling; and somitogenesis. Predicted to be located in cytoplasm. Predicted to be part of NatC complex. Is expressed in blood vasculature; epidermis; and head. Orthologous to human NAA35 (N-alpha-acetyltransferase 35, NatC auxiliary subunit). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
human mouse all
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Genomic context

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See naa35 in Genome Data Viewer
Location:
chromosome: 8
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (49936585..49969184)
105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (49947816..49980415)

Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene neurotrophic tyrosine kinase, receptor, type 2a Neighboring gene ATP/GTP binding carboxypeptidase 1 Neighboring gene glutamine--fructose-6-phosphate transaminase 1 Neighboring gene ANTXR cell adhesion molecule 1a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Embryonic growth-associated protein is one subunit of a novel N-terminal acetyltransferase complex essential for embryonic vascular development. Wenzlau JM, et al. Circ Res, 2006 Mar 31. PMID 16484612
  2. A Genetic Model to Study Increased Hexosamine Biosynthetic Flux. Hugo SE, et al. Endocrinology, 2017 Aug 1. PMID 28582574, Free PMC Article
  3. Transcriptomic profiles of tumor-associated neutrophils reveal prominent roles in enhancing angiogenesis in liver tumorigenesis in zebrafish. Huo X, et al. Sci Rep, 2019 Feb 6. PMID 30728369, Free PMC Article
  4. Mutations in gfpt1 and skiv2l2 cause distinct stage-specific defects in larval melanocyte regeneration in zebrafish. Yang CT, et al. PLoS Genet, 2007 Jun. PMID 17542649, Free PMC Article
  5. Heat-induced masculinization in domesticated zebrafish is family-specific and yields a set of different gonadal transcriptomes. Ribas L, et al. Proc Natl Acad Sci U S A, 2017 Feb 7. PMID 28115725, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
acts_upstream_of_or_within N-terminal peptidyl-methionine acetylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within blood vessel morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of TOR signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in smooth muscle cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within somitogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of NatC complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of NatC complex IEA
Inferred from Electronic Annotation
more info
  
part_of NatC complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
N-alpha-acetyltransferase 35, NatC auxiliary subunit
Names
EGAP NAT
MAK10 homolog, amino-acid N-acetyltransferase subunit
embryonic growth-associated protein
protein MAK10 homolog
zEGAP

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199550.1 → NP_955844.1  N-alpha-acetyltransferase 35, NatC auxiliary subunit

    See identical proteins and their annotated locations for NP_955844.1

    Status: PROVISIONAL

    Source sequence(s)
    BC053286
    UniProtKB/Swiss-Prot
    Q7T322
    Related
    ENSDARP00000089478.3, ENSDART00000098707.6
    Conserved Domains (1) summary
    pfam04112
    Location:45 → 180
    Mak10; Mak10 subunit, NatC N(alpha)-terminal acetyltransferase

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007119.7 Reference GRCz11 Primary Assembly

    Range
    49936585..49969184
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7T322.1 GenPept UniProtKB/Swiss-Prot:Q7T322

Gene LinkOut

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