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Chrac-16 Chromatin accessibility complex 16kD protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32166, updated on 10-May-2024

Summary

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Official Symbol
Chrac-16provided by FlyBase
Official Full Name
Chromatin accessibility complex 16kD proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0043001
Locus tag
Dmel_CG15736
See related
AllianceGenome:FB:FBgn0043001
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
15736; 20K protein; BcDNA:RE59557; CG15736; CHRAC; CHRAC-16; Chrac16; CHRAC16; Dmel\CG15736; joey
Summary
Enables protein heterodimerization activity. Involved in nucleosome mobilization. Part of CHRAC. Is expressed in several structures, including central nervous system; female germline cell; mesoderm; somatic muscle primordium; and visceral muscle primordium. Orthologous to human CHRAC1 (chromatin accessibility complex subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See Chrac-16 in Genome Data Viewer
Location:
11A1-11A1; 1-38 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (12017225..12017961, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (11911258..11911994, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene furrowed Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene regucalcin Neighboring gene LSM12 homolog a Neighboring gene Transport and Golgi organization 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The histone fold subunits of Drosophila CHRAC facilitate nucleosome sliding through dynamic DNA interactions. Hartlepp KF, et al. Mol Cell Biol, 2005 Nov. PMID 16260604, Free PMC Article
  2. A role for tuned levels of nucleosome remodeler subunit ACF1 during Drosophila oogenesis. Börner K, et al. Dev Biol, 2016 Mar 15. PMID 26851213, Free PMC Article
  3. The DNA chaperone HMGB1 facilitates ACF/CHRAC-dependent nucleosome sliding. Bonaldi T, et al. EMBO J, 2002 Dec 16. PMID 12486007, Free PMC Article
  4. Acf1, the largest subunit of CHRAC, regulates ISWI-induced nucleosome remodelling. Eberharter A, et al. EMBO J, 2001 Jul 16. PMID 11447119, Free PMC Article
  5. Chromatin-remodelling factor CHRAC contains the ATPases ISWI and topoisomerase II. Varga-Weisz PD, et al. Nature, 1997 Aug 7. PMID 9252192

See all (51) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. X-ray crystallographic structure of Drosophila melanogaster CHRAC14-CHRAC16 dimer
    Title: The histone fold subunits of Drosophila CHRAC facilitate nucleosome sliding through dynamic DNA interactions.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA-templated DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chromatin remodeling IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of CHRAC IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of CHRAC IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
chromatin accessibility complex 16kD protein
Names
CG15736-PA
CG15736-PB
Chrac-16-PA
Chrac-16-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    12017225..12017961 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298219.1 → NP_001285148.1  chromatin accessibility complex 16kD protein, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285148.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9V452
    Conserved Domains (1) summary
    pfam00808
    Location:18 → 83
    CBFD_NFYB_HMF; Histone-like transcription factor (CBF/NF-Y) and archaeal histone

  2. NM_132548.3 → NP_572776.1  chromatin accessibility complex 16kD protein, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572776.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9V452
    Related
    FBpp0073475
    Conserved Domains (1) summary
    pfam00808
    Location:18 → 83
    CBFD_NFYB_HMF; Histone-like transcription factor (CBF/NF-Y) and archaeal histone
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
2BYK_A.1
2BYK_C.1
2BYM_A.1
2BYM_C.1
Q9V452.1 Q9V452

Gene LinkOut

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