dohh deoxyhypusine hydroxylase/monooxygenase [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: dohhprovided by ZNC
Official Full Name: deoxyhypusine hydroxylase/monooxygenaseprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-451
See related: Ensembl:ENSDARG00000003564 AllianceGenome:ZFIN:ZDB-GENE-030131-451
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: hlrc1; fb33c04; zgc:56338; wu:fb33c04
Summary: Predicted to enable deoxyhypusine monooxygenase activity and iron ion binding activity. Predicted to be involved in peptidyl-lysine modification to peptidyl-hypusine. Orthologous to human DOHH (deoxyhypusine hydroxylase). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 8

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	8	NC_007119.7 (20852996..20858676, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	8	NC_007119.6 (20820911..20826591, complement)

Chromosome 8 - NC_007119.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables deoxyhypusine monooxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables deoxyhypusine monooxygenase activity	IEA Inferred from Electronic Annotation more info
enables deoxyhypusine monooxygenase activity	ISS Inferred from Sequence or Structural Similarity more info
enables iron ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables monooxygenase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within peptidyl-lysine modification to peptidyl-hypusine	IEA Inferred from Electronic Annotation more info
involved_in peptidyl-lysine modification to peptidyl-hypusine	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info

General protein information

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Preferred Names: deoxyhypusine hydroxylase

Names: HEAT-like (PBS lyase) repeat containing 1

NP_955857.1

EC 1.14.99.29

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199563.2 → NP_955857.1 deoxyhypusine hydroxylase

See identical proteins and their annotated locations for NP_955857.1

Status: PROVISIONAL

Source sequence(s)

BC046086

UniProtKB/Swiss-Prot

Q7ZUX6

Related

ENSDARP00000011317.4, ENSDART00000018515.5

Conserved Domains (3) summary

smart00567
Location:85 → 114

EZ_HEAT; E-Z type HEAT repeats

pfam13646
Location:162 → 251

HEAT_2; HEAT repeats

sd00044
Location:257 → 283

HEAT; HEAT repeat [structural motif]