ctsa cathepsin A [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ctsaprovided by ZNC
Official Full Name: cathepsin Aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-537
See related: Ensembl:ENSDARG00000098114 AllianceGenome:ZFIN:ZDB-GENE-030131-537
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: Ppgb; zgc:65802; wu:fb33g02; wu:fb36c08; wu:fj91g05
Summary: Predicted to enable serine-type carboxypeptidase activity. Predicted to act upstream of or within proteolysis. Is expressed in brain and muscle. Human ortholog(s) of this gene implicated in galactosialidosis and lysosomal storage disease. Orthologous to human CTSA (cathepsin A). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 6

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	6	NC_007117.7 (55396807..55423216, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	6	NC_007117.6 (55386994..55411791, complement)

Chromosome 6 - NC_007117.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Markers

fb36c08.x1 (e-PCR)
- UniSTS:190471

fj38d08.x1 (e-PCR)
- UniSTS:199257

fb33g02 (e-PCR)
- UniSTS:189025

fj91g05.x1 (e-PCR)
- UniSTS:200321

fb36c08 (e-PCR)
- UniSTS:187107

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables carboxypeptidase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info
enables serine-type carboxypeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type carboxypeptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: lysosomal protective protein

Names: galactosialidosis; protective protein for beta-galactosidase

NP_956844.1

EC 3.4.16.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.