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clk4a CDC-like kinase 4a [ Danio rerio (zebrafish) ]

Gene ID: 321857, updated on 9-Dec-2024

Summary

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Official Symbol
clk4aprovided by ZNC
Official Full Name
CDC-like kinase 4aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-576
See related
Ensembl:ENSDARG00000089372 AllianceGenome:ZFIN:ZDB-GENE-030131-576
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
clk4; wu:fa26d04; wu:fb37c01
Summary
Predicted to enable protein serine/threonine kinase activity and protein tyrosine kinase activity. Predicted to be involved in regulation of RNA splicing. Predicted to act upstream of or within protein phosphorylation. Predicted to be active in nucleus. Orthologous to human CLK4 (CDC like kinase 4). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See clk4a in Genome Data Viewer
Location:
chromosome: 14
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (6933924..6944512, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (6627210..6637780, complement)

Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene collagen alpha-1(XXIII) chain-like Neighboring gene uncharacterized LOC137487509 Neighboring gene uncharacterized LOC137487510 Neighboring gene receptor for activated C kinase 1 Neighboring gene NME/NM23 family member 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
  2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine/tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of RNA splicing IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
dual specificity protein kinase CLK4
NP_001373164.1
XP_003199888.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001386235.1 → NP_001373164.1  dual specificity protein kinase CLK4

    Status: VALIDATED

    Source sequence(s)
    CABZ01078974, FP102782
    UniProtKB/TrEMBL
    A0A8M2BKC5
    Related
    ENSDARP00000134154.1, ENSDART00000162196.2
    Conserved Domains (1) summary
    cl21453
    Location:1 → 251
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007125.7 Reference GRCz11 Primary Assembly

    Range
    6933924..6944512 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_003199840.5 → XP_003199888.1  dual specificity protein kinase CLK4 isoform X1

    UniProtKB/TrEMBL
    A0A8M1RNS5, E7F7P1
    Related
    ENSDARP00000108440.2, ENSDART00000126279.4
    Conserved Domains (2) summary
    smart00220
    Location:172 → 488
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:159 → 488
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein Strain
Heading Accession and Version

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