dhx15 DEAH (Asp-Glu-Ala-His) box helicase 15 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: dhx15provided by ZNC
Official Full Name: DEAH (Asp-Glu-Ala-His) box helicase 15provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-650
See related: Ensembl:ENSDARG00000015392 AllianceGenome:ZFIN:ZDB-GENE-030131-650
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: im:2639158; wu:fb38f09; wu:fk62f05
Summary: Predicted to enable RNA binding activity and helicase activity. Acts upstream of or within definitive hemopoiesis; digestive tract development; and vasculature development. Predicted to be part of spliceosomal complex. Is expressed in several structures, including eye; intestine; liver; pectoral fin; and pectoral fin bud. Orthologous to human DHX15 (DEAH-box helicase 15). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 7

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	7	NC_007118.7 (71278614..71331729, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	7	NC_007118.6 (71039559..71092630, complement)

Chromosome 7 - NC_007118.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Identification of Dhx15 as a Major Regulator of Liver Development, Regeneration, and Tumor Growth in Zebrafish and Mice.
Title: Identification of Dhx15 as a Major Regulator of Liver Development, Regeneration, and Tumor Growth in Zebrafish and Mice.
Dhx15 regulates zebrafish intestinal development through the Wnt signaling pathway.
Title: Dhx15 regulates zebrafish intestinal development through the Wnt signaling pathway.
Dhx15 regulates zebrafish definitive hematopoiesis through the unfolded protein response pathway.
Title: Dhx15 regulates zebrafish definitive hematopoiesis through the unfolded protein response pathway.
Dhx15 deficiency leads to pleiotropic morphological phenotypes in homozygous mutant embryos starting at 3 days post fertilization (dpf) that result in lethality by 7 dpf, revealing an essential role during embryonic development.
Title: Splicing factor DHX15 affects tp53 and mdm2 expression via alternate splicing and promoter usage.

Submit: New GeneRIF Correction

General gene information

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Markers

fb38f09 (e-PCR)
- UniSTS:187159

fc33e04.x1 (e-PCR)
- UniSTS:193581

fi30c12.x1 (e-PCR)
- UniSTS:197236

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA helicase activity	IEA Inferred from Electronic Annotation more info
enables helicase activity	IBA Inferred from Biological aspect of Ancestor more info
enables helicase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within blood vessel morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within definitive hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within digestive tract development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lymph vessel morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of spliceosomal complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ATP-dependent RNA helicase DHX15

Names: DEAH (Asp-Glu-Ala-His) box polypeptide 15

NP_001108613.1

EC 3.6.1.-

XP_068078262.1

EC 3.6.1.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001115141.1 → NP_001108613.1 ATP-dependent RNA helicase DHX15

Status: PROVISIONAL

Source sequence(s)

CU651678

UniProtKB/TrEMBL

A0A8M1NI02, E7F3I8

Related

ENSDARP00000075688.4, ENSDART00000081245.6

Conserved Domains (5) summary

smart00490
Location:356 → 449

HELICc; helicase superfamily c-terminal domain

smart00487
Location:105 → 296

DEXDc; DEAD-like helicases superfamily

smart00847
Location:519 → 602

HA2; Helicase associated domain (HA2) Add an annotation

cd00046
Location:128 → 269

DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.

pfam07717
Location:636 → 739

OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold