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lztfl1 leucine zipper transcription factor-like 1 [ Danio rerio (zebrafish) ]

Gene ID: 322226, updated on 2-Nov-2024

Summary

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Official Symbol
lztfl1provided by ZNC
Official Full Name
leucine zipper transcription factor-like 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-945
See related
Ensembl:ENSDARG00000105010 AllianceGenome:ZFIN:ZDB-GENE-030131-945
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fb53f12; zgc:56268; wu:fb53f12
Summary
Acts upstream of or within negative regulation of smoothened signaling pathway. Located in cytoplasm and nucleus. Is expressed in several structures, including gill; integument; liver; muscle; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome 17. Orthologous to human LZTFL1 (leucine zipper transcription factor like 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See lztfl1 in Genome Data Viewer
Location:
chromosome: 24
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (12133889..12253332)
105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (11993716..12113191)

Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103909743 Neighboring gene chemokine (C-C motif) receptor 9b Neighboring gene G2/M phase-specific E3 ubiquitin-protein ligase Neighboring gene uncharacterized LOC137489220

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Molecular Characterization and Functional Analysis of Leucine Zipper Transcription Factor Like 1 in Zebrafish (Danio rerio). Wei Q, et al. Front Physiol, 2019. PMID 31293455, Free PMC Article
  2. Analysis of a conditional gene trap reveals that tbx5a is required for heart regeneration in zebrafish. Grajevskaja V, et al. PLoS One, 2018. PMID 29933372, Free PMC Article
  3. Function-driven discovery of disease genes in zebrafish using an integrated genomics big data resource. Shim H, et al. Nucleic Acids Res, 2016 Nov 16. PMID 27903883, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
involved_in negative regulation of protein localization to cilium IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of smoothened signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
leucine zipper transcription factor-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199587.1 → NP_955881.1  leucine zipper transcription factor-like protein 1

    See identical proteins and their annotated locations for NP_955881.1

    Status: PROVISIONAL

    Source sequence(s)
    BC046036
    UniProtKB/TrEMBL
    Q7ZV21
    Related
    ENSDARP00000139253.1, ENSDART00000168248.2
    Conserved Domains (1) summary
    pfam15294
    Location:20 → 291
    Leu_zip; Leucine zipper

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007135.7 Reference GRCz11 Primary Assembly

    Range
    12133889..12253332
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068217030.1 → XP_068073131.1  leucine zipper transcription factor-like protein 1 isoform X2

  2. XM_068217029.1 → XP_068073130.1  leucine zipper transcription factor-like protein 1 isoform X1

    Related
    ENSDARP00000140403.1, ENSDART00000159029.2
Nucleotide Protein
Heading Accession and Version

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