map1lc3b microtubule-associated protein 1 light chain 3 beta [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: map1lc3bprovided by ZNC
Official Full Name: microtubule-associated protein 1 light chain 3 betaprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-1145
See related: Ensembl:ENSDARG00000101127 AllianceGenome:ZFIN:ZDB-GENE-030131-1145
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: Map1lc3; zgc:56434; wu:fb60g11
Summary: Predicted to enable microtubule binding activity; phosphatidylethanolamine binding activity; and ubiquitin protein ligase binding activity. Predicted to be involved in cellular response to nitrogen starvation and macroautophagy. Predicted to act upstream of or within autophagy. Located in cytosol. Is expressed in several structures, including cardiovascular system; central nervous system; liver; neural tube; and pleuroperitoneal region. Orthologous to several human genes including MAP1LC3B (microtubule associated protein 1 light chain 3 beta). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 25

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	25	NC_007136.7 (12494108..12506027)
105	previous assembly	GRCz10 (GCF_000002035.5)	25	NC_007136.6 (12397603..12409522)

Chromosome 25 - NC_007136.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Autophagy and Lc3-Associated Phagocytosis in Zebrafish Models of Bacterial Infections.
Title: Autophagy and Lc3-Associated Phagocytosis in Zebrafish Models of Bacterial Infections.
Lc3-associated phagocytosis is the major host protective autophagy-related pathway responsible for macrophage defense against Salmonella during systemic infection.
Title: Macrophages target Salmonella by Lc3-associated phagocytosis in a systemic infection model.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylethanolamine binding	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in autophagosome assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in autophagosome maturation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within autophagy	IEA Inferred from Electronic Annotation more info
involved_in cellular response to nitrogen starvation	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitophagy	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in autophagosome membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in endomembrane system	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: microtubule-associated proteins 1A/1B light chain 3B

Names: Lc3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.