slc2a2 solute carrier family 2 member 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: slc2a2provided by ZNC
Official Full Name: solute carrier family 2 member 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-1213
See related: Ensembl:ENSDARG00000056196 AllianceGenome:ZFIN:ZDB-GENE-030131-1213
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: glut2; wu:fb62h10
Summary: Enables D-glucose transmembrane transporter activity. Acts upstream of or within D-glucose import; brain development; and liver development. Predicted to be located in membrane. Predicted to be active in brush border and plasma membrane. Is expressed in several structures, including digestive system; muscle; nervous system; pleuroperitoneal region; and yolk syncytial layer. Human ortholog(s) of this gene implicated in Fanconi-Bickel syndrome; glycogen storage disease; and type 2 diabetes mellitus. Orthologous to human SLC2A2 (solute carrier family 2 member 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 2

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (25816896..25837959)
105	previous assembly	GRCz10 (GCF_000002035.5)	2	NC_007113.6 (26161262..26182325)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Glut2 has an essential role during brain development by facilitating the uptake and availability of glucose and support the involvement of glut2 in brain glucose sensing.
Title: GLUT2-mediated glucose uptake and availability are required for embryonic brain development in zebrafish.
The structure and function of GLUT2 has been remarkably well conserved during vertebrate evolution and open the way for the use of zebrafish as a model species in which to study the biology and pathophysiology of GLUT2.
Title: Evolutionary structural and functional conservation of an ortholog of the GLUT2 glucose transporter gene (SLC2A2) in zebrafish.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

AI497169 (e-PCR)
- UniSTS:206364

fc52d11 (e-PCR)
- UniSTS:189312

fb62h10.x1 (e-PCR)
- UniSTS:203402

fj04f02.x1 (e-PCR)
- UniSTS:198364

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables D-glucose transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables D-glucose transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables transmembrane transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in D-glucose import	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within D-glucose import	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within D-glucose import	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within D-glucose transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within brain development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dehydroascorbic acid transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within hexose transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within liver development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in brush border	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

Go to the top of the page Help

Preferred Names: solute carrier family 2, facilitated glucose transporter member 2

Names: solute carrier family 2 (facilitated glucose transporter), member 2; zglut2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001042721.1 → NP_001036186.1 solute carrier family 2, facilitated glucose transporter member 2

See identical proteins and their annotated locations for NP_001036186.1

Status: PROVISIONAL

Source sequence(s)

DQ098687

UniProtKB/TrEMBL

Q102R8

Related

ENSDARP00000073100.5, ENSDART00000078639.7

Conserved Domains (2) summary

cd06174
Location:76 → 462

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

pfam00083
Location:12 → 477

Sugar_tr; Sugar (and other) transporter