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uap1 UDP-N-acetylglucosamine pyrophosphorylase 1 [ Danio rerio (zebrafish) ]

Gene ID: 322513, updated on 2-Nov-2024

Summary

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Official Symbol
uap1provided by ZNC
Official Full Name
UDP-N-acetylglucosamine pyrophosphorylase 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-1233
See related
Ensembl:ENSDARG00000052170 AllianceGenome:ZFIN:ZDB-GENE-030131-1233
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fb63d12; zgc:55280; wu:fb63d12
Summary
Predicted to enable UDP-N-acetylglucosamine diphosphorylase activity. Predicted to be involved in UDP-N-acetylglucosamine biosynthetic process. Is expressed in several structures, including EVL; ectoderm; hatching gland; pectoral fin; and polster. Orthologous to human UAP1 (UDP-N-acetylglucosamine pyrophosphorylase 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See uap1 in Genome Data Viewer
Location:
chromosome: 6
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (35036167..35052199, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (35052806..35068904, complement)

Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101883640 Neighboring gene hydroxysteroid (17-beta) dehydrogenase 7 Neighboring gene discoidin domain receptor tyrosine kinase 2a Neighboring gene U2AF homology motif (UHM) kinase 1 Neighboring gene nitric oxide synthase 1 (neuronal) adaptor protein a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Rbfox-regulated alternative splicing is critical for zebrafish cardiac and skeletal muscle functions. Gallagher TL, et al. Dev Biol, 2011 Nov 15. PMID 21925157, Free PMC Article
  2. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
  3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables UDP-N-acetylglucosamine diphosphorylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables UDP-N-acetylglucosamine diphosphorylase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables uridylyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in UDP-N-acetylglucosamine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
UDP-N-acetylhexosamine pyrophosphorylase
Names
UDP-N-acteylglucosamine pyrophosphorylase 1
NP_001352191.1
NP_997786.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001365262.1 → NP_001352191.1  UDP-N-acetylhexosamine pyrophosphorylase isoform 1

    Status: VALIDATED

    Source sequence(s)
    CR855312, CR855385
    UniProtKB/TrEMBL
    A0A0R4INK2, A0A8M9PLV6, Q803Z1
    Related
    ENSDARP00000135567.1, ENSDART00000170116.3
    Conserved Domains (1) summary
    cd04193
    Location:87 → 409
    UDPGlcNAc_PPase; UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc

  2. NM_212621.2 → NP_997786.2  UDP-N-acetylhexosamine pyrophosphorylase isoform 2

    Status: VALIDATED

    Source sequence(s)
    CR855312, CR855385
    UniProtKB/TrEMBL
    Q803Z1
    Related
    ENSDARP00000068459.4, ENSDART00000073970.6
    Conserved Domains (1) summary
    cd04193
    Location:87 → 409
    UDPGlcNAc_PPase; UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007117.7 Reference GRCz11 Primary Assembly

    Range
    35036167..35052199 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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