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rpl3 ribosomal protein L3 [ Danio rerio (zebrafish) ]

Gene ID: 322571, updated on 2-Nov-2024

Summary

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Official Symbol
rpl3provided by ZNC
Official Full Name
ribosomal protein L3provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-1291
See related
Ensembl:ENSDARG00000003599 AllianceGenome:ZFIN:ZDB-GENE-030131-1291
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
wu:fa99g02; wu:fb65e09; zgc:110350
Summary
Predicted to enable RNA binding activity. Predicted to be a structural constituent of ribosome. Acts upstream of or within exocrine pancreas development. Predicted to be located in ribosome. Predicted to be part of cytosolic large ribosomal subunit. Is expressed in eye; liver; and pancreas. Used to study Shwachman-Diamond syndrome. Orthologous to human RPL3 (ribosomal protein L3). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See rpl3 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (29867225..29871348, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (29736383..29740506, complement)

Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137490615 Neighboring gene calcium channel, voltage-dependent, gamma subunit 2a Neighboring gene small nucleolar RNA SNORA54 Neighboring gene small nucleolar RNA U83B Neighboring gene solute carrier family 25 member 39 Neighboring gene ribosomal protein L27

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. A Novel SLC5A5 Variant Reveals the Crucial Role of Kinesin Light Chain 2 in Thyroid Hormonogenesis. Martín M, et al. J Clin Endocrinol Metab, 2021 Jun 16. PMID 33912899, Free PMC Article
  2. Nuclear Organization during Hepatogenesis in Zebrafish Requires Uhrf1. Madakashira BP, et al. Genes (Basel), 2021 Jul 16. PMID 34356097, Free PMC Article
  3. Ribosomal biogenesis genes play an essential and p53-independent role in zebrafish pancreas development. Provost E, et al. Development, 2012 Sep. PMID 22872088, Free PMC Article
  4. Brain Proteome and Behavioural Analysis in Wild Type, BDNF(+/-) and BDNF(-/-) Adult Zebrafish (Danio rerio) Exposed to Two Different Temperatures. Maffioli E, et al. Int J Mol Sci, 2022 May 17. PMID 35628418, Free PMC Article
  5. Single-cell RNA-sequencing uncovers transcriptional states and fate decisions in haematopoiesis. Athanasiadis EI, et al. Nat Commun, 2017 Dec 11. PMID 29229905, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Knockdown or mutation of either rpl3 or pes resulted in impaired expansion of pancreatic progenitor cells.
    Title: Ribosomal biogenesis genes play an essential and p53-independent role in zebrafish pancreas development.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC110350

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of ribosome IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within exocrine pancreas development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in translation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of cytosolic large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
located_in ribosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
large ribosomal subunit protein uL3
NP_001001590.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001590.1 → NP_001001590.1  large ribosomal subunit protein uL3

    See identical proteins and their annotated locations for NP_001001590.1

    Status: PROVISIONAL

    Source sequence(s)
    AY561514
    UniProtKB/TrEMBL
    A0A2R8Q924, Q5BJJ2, Q6Q418
    Related
    ENSDARP00000003700.7, ENSDART00000011251.10
    Conserved Domains (2) summary
    PTZ00103
    Location:1 → 400
    PTZ00103; 60S ribosomal protein L3; Provisional
    cl00324
    Location:3 → 375
    RplC; Ribosomal protein L3 [Translation, ribosomal structure and biogenesis]

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007114.7 Reference GRCz11 Primary Assembly

    Range
    29867225..29871348 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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