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slc26a5 solute carrier family 26 member 5 [ Danio rerio (zebrafish) ]

Gene ID: 322846, updated on 4-Jan-2025

Summary

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Official Symbol
slc26a5provided by ZNC
Official Full Name
solute carrier family 26 member 5provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-1566
See related
Ensembl:ENSDARG00000022424 AllianceGenome:ZFIN:ZDB-GENE-030131-1566
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
pres; fb73d12; fb74g12; wu:fb73d12; wu:fb74g12
Summary
Enables formate transmembrane transporter activity; oxalate:chloride antiporter activity; and sulfate:chloride antiporter activity. Acts upstream of or within several processes, including chloride transport; oxalate transport; and sulfate transmembrane transport. Located in cytoplasm and plasma membrane. Is expressed in hair cell; inner ear; lagena; utricle; and yolk syncytial layer. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 61. Orthologous to human SLC26A5 (solute carrier family 26 member 5). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
human mouse all
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Genomic context

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See slc26a5 in Genome Data Viewer
Location:
chromosome: 4
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (14932537..14954029, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (14933782..14955274, complement)

Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene PR domain containing 4 Neighboring gene proteasome 26S subunit, ATPase 2 Neighboring gene tetraspanin 33a Neighboring gene smoothened, frizzled class receptor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Comparative Molecular Dynamics Investigation of the Electromotile Hearing Protein Prestin. Abrusci G, et al. Int J Mol Sci, 2021 Aug 2. PMID 34361083, Free PMC Article
  2. Identification and characterization of amphibian SLC26A5 using RNA-Seq. Wang Z, et al. BMC Genomics, 2021 Jul 22. PMID 34294052, Free PMC Article
  3. Voltage-sensitive prestin orthologue expressed in zebrafish hair cells. Albert JT, et al. J Physiol, 2007 Apr 15. PMID 17272340, Free PMC Article
  4. A motif of eleven amino acids is a structural adaptation that facilitates motor capability of eutherian prestin. Tan X, et al. J Cell Sci, 2012 Feb 15. PMID 22399806, Free PMC Article
  5. From zebrafish to mammal: functional evolution of prestin, the motor protein of cochlear outer hair cells. Tan X, et al. J Neurophysiol, 2011 Jan. PMID 21047933, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. results show, for the first time, that the substitution of a span of 11 amino acid residues confers the electrogenic anion transporters of zebrafish and chicken prestins with motor-like function
    Title: A motif of eleven amino acids is a structural adaptation that facilitates motor capability of eutherian prestin.
  2. Motor function is an innovation of therian prestin and is concurrent with diminished transporter capabilities.
    Title: From zebrafish to mammal: functional evolution of prestin, the motor protein of cochlear outer hair cells.
  3. Compared with mammalian prestin, charge movements mediated by zprestin display a weaker voltage dependence and slower kinetics; they occur at more positive membrane voltages, and are not associated with electromotile responses.
    Title: Voltage-sensitive prestin orthologue expressed in zebrafish hair cells.
  4. sequence conservation between mammalian and nonmammalian prestin together with a common pharmacology of electromotility and divalent antiport
    Title: Nonmammalian orthologs of prestin (SLC26A5) are electrogenic divalent/chloride anion exchangers.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables bicarbonate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chloride transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables formate transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables monoatomic ion transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables oxalate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxalate transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables oxalate:chloride antiporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables secondary active sulfate transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables secondary active sulfate transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables sulfate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sulfate:chloride antiporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in chloride transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within chloride transport IDA
Inferred from Direct Assay
more info
 PubMed 
NOT involved_in cochlear outer hair cell electromotile response IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within oxalate transport IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within regulation of membrane potential IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in sulfate transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within sulfate transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
prestin
Names
solute carrier family 26 (anion exchanger), member 5
zprestin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_201473.1 → NP_958881.1  prestin

    See identical proteins and their annotated locations for NP_958881.1

    Status: PROVISIONAL

    Source sequence(s)
    BC054604
    UniProtKB/Swiss-Prot
    A0A8M1PEF9, Q7T2C4
    Related
    ENSDARP00000036010.3, ENSDART00000038642.4
    Conserved Domains (3) summary
    cd07042
    Location:643 → 719
    STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
    TIGR00815
    Location:67 → 722
    sulP; high affinity sulphate transporter 1
    cl00596
    Location:259 → 366
    LrgB; LrgB-like family

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007115.7 Reference GRCz11 Primary Assembly

    Range
    14932537..14954029 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7T2C4.1 GenPept UniProtKB/Swiss-Prot:Q7T2C4

Gene LinkOut

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