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nup50 nucleoporin 50 [ Danio rerio (zebrafish) ]

Gene ID: 322969, updated on 4-Jan-2025

Summary

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Official Symbol
nup50provided by ZNC
Official Full Name
nucleoporin 50provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-1689
See related
Ensembl:ENSDARG00000017454 AllianceGenome:ZFIN:ZDB-GENE-030131-1689
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
wu:fa56e03; wu:fb78a08
Summary
Acts upstream of or within neuron projection morphogenesis; swimming behavior; and thigmotaxis. Predicted to be located in nucleus. Predicted to be part of nuclear pore. Orthologous to human NUP50 (nucleoporin 50). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
human mouse all
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Genomic context

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See nup50 in Genome Data Viewer
Location:
chromosome: 4
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (74813488..74961852)
105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (73490756..73523192)

Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene potassium voltage-gated channel, shaker-related subfamily, member 1b Neighboring gene potassium voltage-gated channel subfamily A member 1 Neighboring gene PHD finger protein 21B Neighboring gene uncharacterized LOC137491581 Neighboring gene uncharacterized LOC108183517 Neighboring gene kiaa0930 Neighboring gene LARGE xylosyl- and glucuronyltransferase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Integrative genetic analysis illuminates ALS heritability and identifies risk genes. Megat S, et al. Nat Commun, 2023 Jan 20. PMID 36670122, Free PMC Article
  2. A Toolbox for Efficient Proximity-Dependent Biotinylation in Zebrafish Embryos. Rosenthal SM, et al. Mol Cell Proteomics, 2021. PMID 34332124, Free PMC Article
  3. Contrasted innate responses to two viruses in zebrafish: insights into the ancestral repertoire of vertebrate IFN-stimulated genes. Briolat V, et al. J Immunol, 2014 May 1. PMID 24683187
  4. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
  5. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
acts_upstream_of_or_within intracellular transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within mRNA transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within neuron projection morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within swimming behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within thigmotaxis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of nuclear pore IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
nuclear pore complex protein Nup50
Names
nucleoporin 50kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_201580.2 → NP_963874.2  nuclear pore complex protein Nup50

    See identical proteins and their annotated locations for NP_963874.2

    Status: PROVISIONAL

    Source sequence(s)
    BC065637
    UniProtKB/TrEMBL
    Q6P0F8
    Related
    ENSDARP00000017103.7, ENSDART00000004739.8
    Conserved Domains (2) summary
    cd13170
    Location:304 → 420
    RanBD_NUP50; Nucleoporin 50 Ran-binding domain
    pfam08911
    Location:3 → 63
    NUP50; NUP50 (Nucleoporin 50 kDa)

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007115.7 Reference GRCz11 Primary Assembly

    Range
    74813488..74961852
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068219518.1 → XP_068075619.1  nuclear pore complex protein Nup50 isoform X1

  2. XM_068219517.1 → XP_068075618.1  nuclear pore complex protein Nup50 isoform X1

    Related
    ENSDARP00000155325.1, ENSDART00000192755.1
Nucleotide Protein Strain
Heading Accession and Version

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